Virolex is an antiviral drug.
Release form and composition
The drug is produced in the form of tablets, a lyophilisate for the preparation of a solution for infusion, eye ointment and cream for external use.
The composition of Virolex tablets includes 200 mg of acyclovir, lactose and microcrystalline cellulose as auxiliary substances.
In one vial of lyophilisate is 250 mg of acyclovir in the form of sodium salt.
One gram of eye ointment contains 30 mg of acyclovir and white petrolatum as an additional component.
One gram of Virolex contains 50 mg of acyclovir and such excipients: cetostearyl alcohol, white soft paraffin and liquid paraffin, sodium lauryl sulfate, polypropylene glycol, poloxamer 407 and purified water.
Indications for use
According to the instructions for Virolex, orally and intravenously, the drug is prescribed for:
- Treatment of infectious diseases caused by herpes simplex viruses type I and II;
- Therapy of infections caused by Varicella Zoster (Varcella-Zoster - the causative agent of chicken pox and herpes zoster);
- Prevention of infectious diseases, the causative agents of which are Varicella Zoster and Herpes simplex, including in people with reduced immunity;
- Prevention of cytomegalovirus infection in patients undergoing bone marrow transplantation.
As an auxiliary drug, Virolex in the form of injections and tablets are prescribed to patients with severe immunodeficiency (including in the clinical picture of HIV infection).
In the form of eye ointment, Virolex, according to the instructions, is used to treat keratitis and other eye lesions caused by the herpes simplex virus.
Outwardly in the form of a cream, the drug is prescribed for the treatment of infectious skin diseases caused by Varicella Zoster and Herpes simplex.
Regardless of the dosage form, the use of Virolex is contraindicated in the presence of hypersensitivity to acyclovir or any auxiliary component of the drug.
In the form of tablets and injections, the drug is not recommended for use during lactation, because acyclovir is excreted in breast milk. During pregnancy, Virolex is prescribed only for health reasons, after a careful assessment of the ratio of the expected benefits for the future mother and the potential risks to the development of her baby.
With caution, the drug is prescribed for the elderly, as well as for patients with impaired renal function and renal failure.
Dosing and Administration
Adults for the treatment of primary infections Herpes simplex Virolex prescribed 1 tablet five times a day. The course of therapy is usually 5 days, but in severe cases may be extended. In patients with significantly weakened immune systems, for example, with suppressed intestinal absorption or after bone marrow transplantation, a single dose of the drug is increased to 400 mg, or intravenous injections of acyclovir are prescribed.
For the treatment of recurrent Herpes simplex patients with normal and weakened immune systems, Virolex is prescribed 1 tablet four times a day, people with serious impairments of immune protection are increased to 2 tablets per reception.
For diseases that are caused by the virus Varicella Zoster, the drug is taken 4 tablets five times a day. The course of treatment is 7 days.
For children over 2 years old, Virolex is prescribed in doses similar to those for adults, and babies under 2 years of age are halved.
A solution is prepared from the Virolex lyophilisate, which is administered intravenously at an interval of 8 hours:
- Adults and children over 12 years - at the rate of 5-10 mg per kilogram of weight;
- Children from 3 months to 12 years - at the rate of 250-500 mg per square meter of body surface;
- Newborns up to 3 months - at the rate of 10 mg per kg of body weight.
When treating ophthalmologic diseases, Virolex ointment is used - it is placed in the lower conjunctival sac 5 times a day. The dose depends on the indications, the duration of treatment is from 7 to 10 days, with interstitial forms of the disease - up to 20 days. After the complete disappearance of symptoms, it is recommended to use the ointment for at least three days.
Cream light massaging movements applied to the affected areas of the body 5 times a day. The duration of the use of Virolex - 5-10 days. It is not recommended to apply the product to the mucous membranes of the eyes, mouth and genitals, as there is the likelihood of pronounced local inflammation.
Possible side effects with the use of Virolex:
- When taken orally: abdominal pain, nausea, diarrhea, vomiting, headache, skin rash, fever, dizziness, drowsiness or insomnia, hallucinations, fatigue, decreased concentration, rarely - transient increase in liver enzymes, creatinine, urea, concentration blood bilirubin, as well as hair loss, leukopenia, erythropenia, lymphocytopenia;
- When administered intravenously: nausea, vomiting, inflammation or phlebitis at the injection site, crystalluria, acute renal failure, encephalopathy, manifested by agitation, hallucinations, confusion, psychosis, drowsiness, tremor, convulsions, coma;
- When applied topically in ophthalmology: conjunctivitis, blepharitis, superficial punctate keratitis, burning sensation at the site of application;
- When applied topically: peeling, itching, dryness and burning of the skin at the site of application, rash, erythema, in contact with mucous membranes - inflammation.
Analogs of Virolex:
- For systemic use - Acyclovir, Vivoraks, Acyclovir-AKOS, Herpetad, Acyclovir Sandoz, Acyclovir-Teva, Atsiklostad, Gerperaks, Medovir, Zovirax, Provirsan;
- For use in ophthalmology: Acyclovir and Zovirax;
- For external use: Atsigerpin, Acyclovir, Acyclovir-Akri, Vivoraks, Atsiklovir Geksal, Atsiklostad, Gerviraks, Gerperaks, Herpetad, Zovirax.
Terms and conditions of storage
Store the drug should be at a temperature up to 25 ºC in a place protected from the sun.
Shelf life of tablets and eye ointment - 5 years, freeze-dried and cream - 3 years.