Vikasol - a drug that affects the blood and blood formation.
Release form and composition
A 1% solution of Vikasol is produced in the form of a clear, colorless or yellowish liquid, 1 and 2 ml each in ampoules with an ampoule scarifier or a knife for opening in the kit.
One ml of solution contains 10 mg of menadione sodium bisulfite and excipients - hydrochloric acid, sodium metabisulfite and water for injection.
Another form of release of Vikasol are white, odorless tablets with a sweet, bitter taste in blister packs of 10 and 20, as well as in plastic jars of 30 pcs.
Indications for use
Vikasol is used for the prevention and treatment of hypoprothrombinemia caused by a deficiency of vitamin K in the body, namely:
- Due to the presence of a newborn baby exclusively breastfed or receiving un enriched mixture;
- The malabsorption syndrome causes dysfunction of the pancreas or small intestine, obstructive jaundice, celiac disease, Crohn's disease, resection of the small intestine, sprue, abetalipoproteinemia, prolonged diarrhea, parenteral nutrition, ulcerative colitis and dysentery;
- Due to the intake of certain drugs (antibiotics, salicylates, derivatives of indanedione and coumarin);
- At disturbance of coagulation arising owing to decrease in the content of factors II, VII, IX, X.
Vikasol is also prescribed to newborns with hemorrhagic disease.
The use of Vicasol is contraindicated in hypercoagulation, hemolytic disease of the newborn, thromboembolism, as well as in cases of hypersensitivity to the components of the preparation.
With caution, the drug is prescribed during pregnancy in patients with liver failure or deficiency of glucose-6-phosphate dehydrogenase.
Dosing and Administration
The drug in the form of a solution is used intramuscularly. The daily dose of Vikasol for adults is 30 mg, one-time - 10-15 mg. Tablets are taken orally, at 15-30 mg (adults) per day.
The dosage of the drug for children depends on age, namely:
- For newborns, the dose is up to 4 mg per day;
- Children of the first year of life prescribed from two to five mg per day;
- Patients up to two years old take 6 mg Vikasol per day;
- For children 3-4 years old, the dose of the drug is 8 mg per day;
- Children from five to nine years prescribed 10 mg per day;
- Teenagers (10-14 years) take 15 mg Vicasol daily.
The duration of drug therapy varies within 3-4 days, then a 4-day break is required, after which the treatment is repeated.
In cases of surgical interventions in which severe parenchymal bleeding is possible, Vikasol is used for two or three days before the immediate operation.
The instructions to Vikasol indicated that the drug may cause allergic, other and local reactions, as well as side effects from the blood system, namely:
- The appearance of spots on the skin with repeated injections of Vikasol in the same place, swelling and pain at the injection site (local reactions);
- Skin rash, bronchospasm, facial flushing and itching (allergic reactions);
- Hemolytic anemia, hemolysis in newborns with congenital deficiency of glucose-6-phosphate dehydrogenase (blood system);
- Jaundice, dizziness, change in taste, hyperbilirubinemia, profuse sweat, transient lowering of blood pressure and a weak filling of the pulse (other reactions).
In cases of overdose of Vikasol, hypervitaminosis K occurs, which is manifested by the following symptoms:
- Toxicosis and convulsions in children.
In such cases, the appointment of symptomatic therapy.
Recommended parenteral administration of the drug in cases of diseases that lead to a violation of the outflow of bile.
The use of Vicasol in thrombocytopenic purpura, hemophilia, as well as in the third trimester of pregnancy is not effective.
It is recommended to use phytonadione rather than menadione sodium bisulfite for the prevention of hemorrhagic disease in newborns, since the former is less likely to cause hemolytic anemia and hyperbilirubinemia in patients of this age group, including premature babies.
It should be borne in mind that Vikasol reduces the effectiveness of indirect anticoagulants, does not affect the anticoagulant activity of heparin, and when administered simultaneously with hemolytic drugs increases the risk of side effects.
If necessary, the simultaneous use of the drug with salicylates, broad-spectrum antibiotics, quinine, antibacterial sulfonamides and quinidine in high doses, it is necessary to increase the dose of vitamin K.
An increase in the dose of Vikasol is also required, with simultaneous use with mineral oils, dactinomycin, colestipol, sucralfate, and colestiramine, since they reduce the absorption of vitamin K.
Drug synonyms are not released. The analogue of Vikasol is the drug Fitomenadione (Vitamin K1) solution in oil 10%.
Terms and conditions of storage
Vikasol, according to the instructions, should be stored in a dry, well-ventilated, out of the reach of children and light place, with a temperature varying within 15-25 ° C.
The drug is dispensed from pharmacies in the form of tablets without a doctor's prescription, and the solution for intramuscular administration is prescribed by a doctor. The storage life of Vikasol is three years. After the expiration date of the drug must be disposed of.