Vigantol is a vitamin preparation affecting the exchange of calcium and phosphorus.
Release form and composition
The medicine is produced in the form of an oily transparent, slightly yellowish solution for oral administration, in 1 ml of which is contained:
- 20,000 IU of colecalciferol, which corresponds to 500 μg;
- 939.5 mg of medium chain triglycerides as an auxiliary component.
Implemented Vigantol solution of 10 ml in bottles with a stopper-dropper.
Indications for use
According to the Vigantolu instructions, this vitamin remedy is intended for:
- The treatment and prevention of rickets in children;
- Preventing the development of D-deficiency states caused by a lack of this vitamin in patients belonging to the high-risk group: people with biliary cirrhosis, malabsorption, chronic bowel disease (especially the small division), and also after resection of the small intestine and / or stomach;
- Treatment of hypoparathyroidism (diseases of the endocrine system resulting from parathyroid hormone deficiency) and pseudohypoparathyroidism (hereditary osteodystrophy due to the resistance of peripheral tissues to parathyroid hormone), accompanied by a disorder of calcium-phosphorus metabolism;
- Maintenance therapy for osteoporosis;
- Treatment of osteomalacia, resulting from disorders of mineral metabolism in people over the age of 45 years, due to prolonged immobilization, adherence to dietary nutrition, especially with the rejection of milk and dairy products.
The use of Vigantola, according to the instructions, is contraindicated in:
- Hypervitaminosis D;
- Calcium nephrourolithiasis;
- Renal osteodystomy, accompanied by hyperphosphatemia;
- The presence of hypersensitivity to the drug.
Assign Vigantol, but with extreme caution, carefully assessing the expected benefits and potential risks, with:
- Heart failure;
- Organic heart disease;
- Sarcoidosis and other granulomatosis;
- Acute and Chronic Kidney / Liver Diseases;
- Renal failure;
- Phosphate nephrourolithiasis, including a history;
- Diseases of the digestive tract, including peptic ulcer and 12 duodenal ulcers;
- Taking vitamin D3, including as part of other drugs;
- Simultaneous use of cardiac glycosides, antacids, benzodiazepines, thiazide diuretics, sodium fluoride, phosphorus-containing drugs.
Dosing and Administration
The specific dosage of the drug depends on the evidence and the age of the patient.
For the prevention of rickets, healthy full-term babies Vigantol is recommended to give 1 drop daily from the second week of life (which corresponds to about 667 IU of vitamin D3). In this case, the drug is indicated for use before the child reaches 2 years of age, or at least in the winter months, because It is during this period that there is very little sun, which contributes to the production of this vitamin by the body.
For the purpose of treating rickets, Vigantol is prescribed in an amount of 2-8 drops once a day. The duration of treatment is usually 12 months.
For the prevention of diseases caused by lack of vitamin D3, you should take 1-2 drops once a day.
When malabsorption Vigantol prescribed to prevent the development of vitamin D3 deficiency. Standard dosage - 5-8 drops / day.
For maintenance therapy of osteoporosis, take 2-5 drops once a day.
When osteomalacia caused by lack of D3, Vigantol is shown in the amount of 2-8 drops. It should be taken once a day for one year.
In hypoparathyroidism and pseudo-hypoparathyroidism, the required dose of the drug is determined taking into account the plasma concentration of calcium. The average daily dosage may vary from 15 to 30 drops. In the first 4-6 weeks should constantly monitor the concentration of calcium in the blood, if necessary, adjust the dose of Vigantola. Further analysis is carried out once in 3-6 months and also, if required, increase or decrease the dosage.
If the recommended dosing regimen is observed, the vitamin preparation is generally well tolerated. In some cases, the use of Vigantola arise:
- Nausea, flatulence, constipation or diarrhea, abdominal pain, loss of appetite (side effects of the digestive system);
- Myalgia and arthralgia (reactions from the musculoskeletal system);
- Arrhythmia, increased blood pressure (adverse effects of the cardiovascular system);
- Urticaria, rash, itching (allergic reactions);
- Headache, functional renal impairment, exacerbation of the tuberculous process in the lungs (other side effects of the drug).
When using Vigantol for a long period of time, there is a risk of developing hypercalciuria and hypercalcemia.
If necessary, taking the drug during pregnancy requires careful selection of the dose. This is due to the fact that overdose may develop hypercalcemia and transplacental penetration of vitamin D3 metabolites in the fetus, and this can lead to a delay in physical and mental development, special forms of aortic stenosis.
In addition, it is important to bear in mind that vitamin D3 and its metabolites are excreted in the mother’s milk, therefore caution is also needed when using Vigantol during lactation.
Analogs of Vigantola are:
- According to the active substance: Aquadetrim and Vitamin D3;
- According to the mechanism of action: A.T.10, Alpha D3-Teva, Alfadol, Alfadol-Sa, Van-Alpha, Videhol, Dihydrotachisterol, Oksidevit, Osteotriol, Rocaltrol, Ergocalciferol, Etalfa.
Terms and conditions of storage
From pharmacies Vigantol released by prescription. According to the recommendations of the manufacturer, it should be stored at a temperature of 15-25 ºС in a place protected from sunlight. At observance of these recommendations the expiration date of drops makes 5 years.