Venofer - antianemic drug intended for parenteral use.
Release form and composition
The drug is produced in the form of a solution for intravenous administration, 1 ml of which contains:
- 540 mg of trivalent iron hydroxide sucrose complex (which corresponds to 20 mg of iron);
- Sodium hydroxide and injectable water as auxiliary components.
Implemented solution Venofer 5 ml ampoules of colorless glass, 5 pcs. in a blister strip packaging that is packaged in a carton box.
Indications for use
According to the instructions to Venofer, the drug should be used in case of iron deficiency in the following cases:
- When you need to quickly fill the lack of iron;
- If the patient does not tolerate oral dosage forms of iron preparations or does not comply with the treatment regimen prescribed by the doctor;
- With active inflammatory bowel disease (because in such cases, oral iron supplements are simply ineffective).
The use of Venofer, according to the instructions, is contraindicated:
- With anemia, if it is not associated with iron deficiency;
- In the first trimester of pregnancy;
- In case of hypersensitivity to the drug;
- Patients who have signs of iron overload (hemochromatosis or hemosiderosis);
- When violations of the process of recycling Fe.
Prescribe the drug, but with extreme caution, with the following diseases and conditions:
- Bronchial asthma;
- Renal failure;
- Acute and chronic infectious diseases;
- Polyvalent allergies;
- A history of indications of allergic reactions that occurred during the parenteral administration of iron preparations;
- Low serum iron binding and / or folic acid deficiency;
- Increased serum ferritin content.
Dosing and Administration
Venofer solution is preferably administered intravenously (to reduce the risk of pronounced decrease in blood pressure), but it is also possible to administer intravenously in a jet or venous region of the dialysis system.
Immediately before the infusion, Venofer is diluted with a 0.9% solution of sodium chloride in a ratio of 1:20 (that is, 1 ml of iron - 20 ml of NaCl).
Before the first infusion, a test dose is prescribed to determine if the patient is intolerant to the drug:
- If necessary, drip in / in the introduction: adults and children weighing more than 14 kg - 20 mg of iron (1 ml of solution), children weighing less than 14 kg - at the rate of 1.5 mg of iron per kg (half the daily dosage). The solution is injected within 15 minutes;
- If necessary, a jet in / in the introduction: the dose is similar to those described above, only the solution is injected jet for 1-2 minutes.
If there are no adverse reactions within 15 minutes after the injection, further administration of the drug is continued at the recommended rate, depending on the prescribed dose of Venofer.
Duration of intravenous drip infusion (taking into account the prescribed dosage of the drug):
- 100 mg of iron is administered for at least 15 minutes;
- 200 mg - 30 minutes;
- 300 mg - 1.5 hours;
- 400 mg - 2.5 hours;
- 500 mg - 3.5 hours.
The maximum tolerated single dose is 7 mg of iron per kilogram of the patient’s body weight; it can be administered no faster than over 3.5 hours, regardless of the total dose of Venofer.
The jet is injected in pure form (without diluting NaCl) at a rate of 1 ml / minute. The maximum volume of solution per injection should not exceed 10 ml (200 mg of iron).
Venofer is administered into the venous site of the dialzic system with strict adherence to the rules described for intravenous injection.
The dose is calculated according to a specific formula in each case individually, taking into account the total iron deficiency in the body, taking into account the patient’s body weight and the level of hemoglobin. With blood loss, the dosage is calculated based on the amount of blood lost.
If the resulting therapeutic dose exceeds the maximum allowed for a single injection, Venofer is administered fractionally.
In the event that after 7-14 days of Venofer use, there is no improvement in hematological parameters, re-diagnosis is carried out and the treatment regimen is adjusted.
According to medical reviews, side effects during the period of treatment with Venofer are very rarely observed - no more than in 0.01% of patients.
So, a drug can cause:
- Dizziness, paresthesia, headache, loss of consciousness;
- Decrease in blood pressure, tachycardia, rapid heartbeat, flushing of the face, feeling of heat, collaptoid states;
- Shortness of breath, bronchospasm;
- Abdominal or epigastric pain, diarrhea, nausea, vomiting, change in taste;
- Erythema, rash, pruritus, increased sweating, impaired pigmentation;
- Back pain, myalgia, arthralgia, joint swelling, pain in the limbs;
- Swelling of the face and larynx, anaphylactoid reactions;
- A feeling of heaviness or pain in the chest, asthenia, weakness, pallor, chills, fever, malaise, peripheral edema;
- Pain and swelling at the injection site.
The use of Venofer is allowed only if the diagnosis of anemia was confirmed by the results of relevant laboratory studies.
Analogs of Venofer are:
- Preparations according to the active substance: Argeferr, Likferr 100, FerMed;
- Medicines on the mechanism of action: Dextrafer, CosmoFer, Maltofer, Monofer, Ferrum Lek, Firinekt, Firinzhekt.
Terms and conditions of storage
Venofer is a drug belonging to Schedule B, released from pharmacies by prescription.
Store ampoules at a temperature of 4 to 25 ºC. It is forbidden to freeze!
The shelf life of the solution - 3 years. After dilution at room temperature, the chemical and physical stability of the product is 12 hours. However, from a microbiological point of view, it should be used immediately. Maximum storage time is allowed for 3 hours, provided that the dilution has been carried out under guaranteed aseptic and controlled conditions.