Valtrex is an antiviral drug.
Release form and composition
Valtrex tablets are made, the active component of which is valacyclovir (500 mg in each tablet).
Auxiliary substances of the drug are crospovidone, microcrystalline cellulose, magnesium stearate, povidone K90, colloidal silicon dioxide.
In blister packs of 6 or 10 tablets.
Indications for use
According to the instructions, Valtrex is prescribed to children from 12 years of age and adults to prevent cytomegalovirus infection in the period after kidney transplantation, as well as to prevent graft rejection, opportunistic and herpes viral infections.
Adults Valtrex is prescribed for:
- Treatment of shingles in order to reduce pain. The drug reduces the duration of infection and eliminates acute and postherpetic neuralgia;
- Treatment of infections of the mucous membranes and skin caused by HSV, including primary and secondary genital herpes, labial herpes;
- Prevention of recurrent infections of mucous membranes and skin caused by HSV, as well as the transfer of genital herpes to a healthy partner (in combination with safe sex).
According to the instructions, Valtrex can not be assigned:
- In children up to 12 years (with the prevention of cytomegalovirus infection after organ transplantation);
- At children's age up to 18 years (for all other indications);
- With increased sensitivity to valacyclovir, acyclovir and auxiliary components of the drug.
When using Valtrex, care should be taken when:
- Renal failure;
- Simultaneous use of nephrotoxic drugs;
- Clinically expressed forms of HIV infection.
Dosing and Administration
Valtrex tablets are used inside, regardless of the meal, with a sufficient amount of liquid.
In the treatment of shingles, the recommended dose is 2 tablets three times a day for one week.
When treating infections caused by HSV, the recommended dose of Valtrex is 1 tablet twice a day for 5 days. In severe cases of the disease, the duration of therapy may be extended up to 10 days. It is advisable to begin treatment with the drug at the first manifestations of the disease.
For treating labile herpes, Valtrex is prescribed at a dose of 4 tablets twice a day. In this case, the second dose should be taken 6-12 hours after the first. The duration of such therapy is a day.
For the prevention of recurrent infections caused by HSV, patients with preserved immunity are prescribed 1 tablet of Valtrex per day. Patients with immunodeficiency - 1 tablet twice a day.
To prevent the transmission of genital herpes to a healthy partner, Valtrex is shown to take 1 tablet per day for one year or more daily.
For the prevention of cytomegalovirus after organ transplantation, children from 12 years and adults are prescribed 4 tablets 4 times a day. Treatment should be prescribed as soon as possible after transplantation, gradually reducing the dose depending on creatinine clearance. The duration of therapy is 3 months.
The use of valtrex can cause the following side effects:
- Nervous system: headache, dizziness, hallucinations, confusion, tremor, agitation, convulsions, dysarthria, depression of consciousness, coma;
- Immune system: anaphylaxis;
- Blood system and hematopoietic organs: thrombocytopenia (leukopenia, most often found in immunocompromised patients);
- Respiratory system: shortness of breath;
- Digestive system: nausea, vomiting, abdominal discomfort, diarrhea;
- Biliary tract and liver: reversible hepatic impairment;
- Skin and subcutaneous fatty tissue: photosensitivity, skin rash, pruritus, urticaria, angioedema;
- Urinary system: renal dysfunction, renal colic, acute renal failure.
When using Valtrex, patients at risk of dehydration (old age, etc.) should consume a sufficient amount of fluid.
In patients with renal failure, the likelihood of developing neurological disorders increases, so they should take the drug under the close supervision of a physician.
In the case of the use of Valtrex in high doses over a long period of time, an overdose may develop with the following symptoms:
- Neurological disorders;
- Acute renal failure;
- Confusion and depression of consciousness;
- Nausea and vomiting.
In order to avoid overdose, patients should take the drug under close medical supervision. Hemodialysis is effective for removing acyclovir from the blood.
Clinically significant drug interaction of Valtrex has not been established.
It is necessary to take the drug with caution in high doses in combination with drugs that compete with acyclovir for the route of elimination, since an increase in the concentration of these drugs in blood plasma is not excluded. Also, caution should be combined Valtrex with drugs that affect renal function. It is necessary to monitor kidney function.
In pregnancy, Valtrex is prescribed only when the potential benefit to the mother exceeds the likely risks to the fetus.
Valtrex is contraindicated for nursing mothers. At the time of treatment with a drug, women should refuse breastfeeding.
During therapy with Valtrex, caution should be exercised when managing complex mechanisms that require high concentration of attention.
Structural analogues of Valtrex are the following drugs:
Terms and conditions of storage
According to the instructions, Valtrex is stored in a dark, dry and out of reach of children. The shelf life of the drug is 3 years.