Nimid is a nonsteroidal anti-inflammatory drug from the sulfonanilide group.
Release form and composition
- Tablets (10 each in a blister, 1, 3 or 10 blisters per pack);
- Suspension for oral administration (60 ml in vials);
- Granules for the preparation of oral solution (2 g sachets, in a package of 1 or 30 bags);
- Gel for external use (20, 30 or 100 g in tubes).
The active ingredient of the drug is nimesulide:
- 1 tablet - 100 mg;
- 1 ml of suspension - 10 mg;
- 1 bag of granules - 100 mg;
- 1 g of gel - 10 mg.
- Tablets: Aerosil 200, microcrystalline cellulose, magnesium stearate, croscarmellose sodium;
- Granules: sodium saccharin, povidone K-30, aerosil 200, tabletose 80, citric acid monohydrate, flavoring;
- Gel: propylparaben, disodium edetate, methylparaben, propylene glycol, sodium hydroxide, carbomer 940, flavoring, purified water.
Indications for use
For tablets, suspensions and granules:
- Symptomatic therapy of pain in diseases of the muscles, joints and bones, including with bursitis, rheumatoid arthritis, tendonitis, osteoarthrosis, myalgia;
- Relief of pain caused by diseases of the upper respiratory tract, postoperative and post-traumatic pains, pain in dental and gynecological practice;
- Reduced fever during fever, accompanying diseases of upper respiratory tract and upper respiratory tract.
For the gel:
- Inflammation of the soft tissues due to injury: stretching and bruising of the muscles, damage and rupture of ligaments;
- Degenerative and Inflammatory diseases of the musculoskeletal system, accompanied by pain and edemas: rheumatoid, rheumatoid, arthritic and psoriatic arthritis, ankylosing spondylitis, osteoarthritis, Reiter's syndrome, myositis, tendinitis, myalgia, tenosynovitis, sciatica, lumbago, neuralgia, low back pain with radicular syndromes.
For Nimid in the form of tablets, suspensions and granules:
- Duodenal ulcer and stomach in the acute stage;
- Severe abnormal liver function;
- Hepatotoxic reactions to the drug in history;
- Severe renal dysfunction (creatinine clearance <30 ml / minute);
- Tendency to bleed;
- Heart failure;
- Concurrent use of potentially hepatotoxic drugs;
- Fever and flu-like states;
- Suspicion of acute surgical pathology;
- Chronic alcoholism or drug addiction;
- Pregnancy and lactation;
- Children under 12;
- Hypersensitivity to the drug.
For nimid gel form:
- Dermatitis, infections and skin lesions at sites of application;
- Bronchial asthma caused by taking acetylsalicylic acid;
- Children under 12;
- III trimester pregnancy;
- Hypersensitivity to the drug.
Dosing and Administration
Tablets and suspension for oral administration.
In these dosage forms, Nimid should be taken orally after meals.
The dose and duration of treatment is determined by the doctor. Adults are usually prescribed 100 mg 2 times a day. The maximum permissible daily dose is 400 mg.
Children over 12 years old are prescribed 1.5 mg / kg 2 times a day, but not more than 5 mg / kg / day, children over 12 years old with a body weight of more than 40 kg are given 100 mg 2 times a day.
Granules for the preparation of oral solution
In this dosage form, the drug should be taken orally after a meal.
Adults and children over 12 years old are prescribed 100 mg (1 sachet) 2 times a day. Immediately before taking the contents of the sachet should be dissolved in 1 cup of warm drinking water.
Gel for external use
In this dosage form, Nimid should be applied with a thin layer on parts of the body with the most pronounced pain syndrome, without rubbing, up to 4 times per day.
Hands should be thoroughly washed before and after applying the gel.
When using Nimid granules:
- Allergic reactions: skin rash, itching, urticaria, angioedema; rarely, Stevens-Johnson syndrome, epidermal necrolysis, anaphylactic reactions (dyspnea, bronchospasm, especially in patients with hypersensitivity to acetylsalicylic acid or other NSAIDs);
- Digestive system: nausea, abdominal pain, gastralgia, constipation or diarrhea, changes in transaminase activity; rarely - peptic ulcer and 12 duodenal ulcer, ulcer perforation, gastrointestinal bleeding, acute hepatitis;
- Central nervous system: drowsiness, headache, dizziness;
- Urinary system: oliguria, edema; rarely - hematuria, renal failure,
- Hematopoietic system: rarely - thrombocytopenic purpura.
When using Nimid in the form of tablets and suspensions:
- Allergic reactions: skin rashes, itching, erythema, sweating, dermatitis; rarely - facial edema, erythema multiforme, angioedema, Stevens-Johnson syndrome;
- Digestive system: abdominal pain, nausea, constipation / diarrhea, gastralgia, flatulence; rarely - stomatitis, perforation or gastrointestinal bleeding, peptic ulcer or 12 duodenal ulcers, melena, cholestasis, jaundice, changes in transaminase activity, acute hepatitis;
- Central nervous system: headache, drowsiness, anxiety, dizziness, nightmares, nervousness, encephalopathy;
- Urinary system: urinary retention, edema, dysuria, hematuria; rarely - oliguria, renal failure, interstitial nephritis;
- Blood system: anemia, eosinophilia; rarely - thrombocytopenia, bleeding, pancytopenia, thrombocytopenic purpura;
- Respiratory system: dyspnea; rarely - bronchospasm, bronchial asthma, including those caused by hypersensitivity to acetylsalicylic acid or other NSAIDs;
- Cardiovascular system: arterial hypertension, tachycardia; rarely - tides, fluctuations in blood pressure;
- Allergic reactions: hypersensitivity reactions, anaphylaxis;
- Other: visual impairment, asthenia, hypothermia, hyperkalemia.
When applying Nimid gel form:
- Local reactions: itching, peeling of the skin, urticaria;
- In rare cases: anaphylactic reactions (vasomotor rhinitis, bronchospasm, asphyxiation, angioedema) mainly in patients with hypersensitivity to acetylsalicylic acid or other NSAIDs.
Nimide is recommended to be used in minimum effective doses for as short a period as possible.
If signs of liver damage appear during treatment (nausea, abdominal pain, vomiting, dark urine, anorexia, fatigue) or an increase in liver transaminases, the drug should be discontinued. The same applies to cases of symptoms of gastrointestinal bleeding, deterioration of kidney function, fever and the appearance of flu-like symptoms.
Nimid can have a negative effect on fertility, so it is not recommended for women who are planning to become pregnant.
Special observation during the period of therapy is required for elderly people and patients with hemorrhagic diathesis.
During the use of Nimid should refrain from drinking alcohol, avoid the simultaneous use of other NSAIDs, analgesics and hepatotoxic drugs.
Tablets, suspension and granules
In the case of simultaneous use of acetylsalicylic acid, warfarin or other anticoagulants, the risk of bleeding increases.
Nimid may increase cyclosporine nephrotoxicity.
Nimesulide can reduce the clearance of lithium, thus increasing its concentration in the blood plasma and increasing its toxicity. For this reason, when using such a combination, it is necessary to control the concentration of lithium in the blood plasma.
Caution should be taken nimid simultaneously with furosemide patients with impaired renal function and heart.
When taking nimesulide during the day before or after the use of methotrexate, it is possible to increase the concentration in the blood of the latter and increase its toxicity.
Gel for external use
In the case of the simultaneous use of other drugs from the group of nonsteroidal anti-inflammatory drugs, local irritation in the form of redness of the skin, peeling and urticaria is possible.
Glucocorticoids and antirheumatic drugs (gold preparations, aminoquinolones) can enhance the anti-inflammatory effect of Nimid.
Terms and conditions of storage
Store at a temperature up to 25 ºС in a dark place and out of reach of children. Gel forbidden to freeze.
Shelf life of tablets and gel - 2 years, suspensions and granules - 3 years.