Negrustin is a herbal remedy of antidepressant action.
Release form and composition
Negrustin is available in the following dosage forms:
- Capsules: hard gelatinous, with a matte red body and a matte green lid; the capsules contain grayish-brown powder and / or granules with a characteristic odor (10 pieces in blisters, 3 blisters in a carton box);
- Solution for oral administration (in dark glass bottles with a screw cap with a ring of the first opening and a stopper-dropper 50 or 100 ml, 1 bottle in a cardboard bundle complete with a measuring cup).
The composition of 1 capsule includes:
- Active ingredient: St. John's wort (in the form of a dry extract of the herb 3.5-6.0: 1) - 425 mg;
- Auxiliary components: cellulose - 6.2 mg; lactose monohydrate - 18.7 mg; calcium hydrophosphate dihydrate - 40.5 mg; magnesium stearate - 5 mg; colloidal silicon dioxide - 36.3 mg; Talc - 10 mg.
- Capsule shell: sodium lauryl sulfate - 0.194 mg; gelatin 79.827 mg; copper complex of chlorophyll (chlorophyll-copper, E141) - 0.23 mg; titanium dioxide (E171) - 1.216 mg; yellow iron oxide (E172) - 0.115 mg; iron (III) oxide red (E172) - 0.691 mg; purified water - 13.92 mg.
The composition of 1 ml of solution includes:
- Active ingredient: St. John's wort (liquid herb extract) - 791 mg (0.03-0.05% of total hypericin (respectively - 0.24-0.39 mg / ml));
- Auxiliary components: glycerin, 70% sorbitol, propylene glycol, flavors.
Indications for use
- Depressive states of mild and moderate severity;
- Psychovegetative disorders;
- States of anxiety and anxiety.
- Instructions in the history of photosensitization on the use of drugs St. John's wort;
- Endogenous depression;
- Hypersensitivity to the drug.
Children Negrustin prescribed from 12 years.
Nursing and pregnant women can take the drug after assessing the benefit / risk ratio for mother and child.
Dosing and Administration
Negrustin taken orally, preferably during a meal.
Capsules washed down with a sufficient amount of liquid, they should not be chewed. The solution can be taken undiluted or with a small amount of liquid.
The following dosing regimen is recommended:
- Capsules: single dose - 1 capsule, the multiplicity of reception - 1-2 times a day;
- Oral solution: single dose - 1 ml, the multiplicity of reception - 3 times a day.
The duration of the treatment course is 1.5-2 months. If necessary, the doctor may prescribe repeated courses of therapy.
The following side effects may develop during the use of Negrustin:
- Dermatological reactions: photosensitivity;
- The digestive system: dyspepsia;
- Other: allergic reactions.
While taking Negrustin, especially light-skinned patients, it is recommended to avoid visiting a tanning bed and prolonged insolation.
Combined use with other drugs that cause photosensitization, as well as with monoamine oxidase inhibitors is not recommended.
A single dose of Negrustin oral solution contains about 121 mg of sorbitol. Patients with diabetes should take into account that 1 ml of the solution corresponds to 0.01 bread unit (XE). The drug in this dosage form should be taken with caution in patients with fructose intolerance.
Negrustin can affect the psychophysical abilities of the patient, especially when used simultaneously with alcohol or tranquilizers, which must be taken into account when driving.
When Negrustin is used together with certain drugs, the following effects may occur:
- Cyclosporine, indinavir, protease inhibitors, indirect anticoagulants (warfarin, fenprokumon), digoxin, theophylline, amitriptyline, nortriptyline: weakening of the effect of Negrustin;
- Other antidepressants (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram): increased side effects (in the form of nausea, fear, vomiting, psychomotor agitation);
- Photosensitizing agents: increased photosensitization;
- Oral contraceptives: the development of bleeding.
Terms and conditions of storage
Keep out of reach of children at temperature up to 25 ° C.
- Capsules - 3 years;
- Solution for oral administration - 4 years.