Naproxen is a derivative of naphthyl propionic acid; nonsteroidal anti-inflammatory agent (NSAIDs), which also has antipyretic and analgesic effects.
Release form and composition
Available in tablets (50 each in dark glass bottles, in a cardboard bundle one bottle; 10 each in blisters, in a box of 5 (250 mg) or 2 (500 mg) blisters).
Active ingredient - naproxen: in 1 tablet - 250 or 500 mg.
Indications for use
- Rheumatoid arthritis;
- Arthritic syndrome in rheumatism;
- Ankylosing spondylitis;
- Primary dysmenorrhea;
- Inflammatory diseases and injuries of the musculoskeletal system and soft tissues;
- Fever in infectious and inflammatory diseases.
- The period of exacerbation of erosive and ulcerative diseases of the gastrointestinal tract;
- Aspirin Triad;
- Severe renal dysfunction (creatinine clearance less than 20 ml / min) and abnormal liver function;
- Hematopoiesis disorders;
- Hemorrhagic diathesis;
- Children's age up to 1 year;
- The attacks of bronchospasm caused by taking NSAIDs in history;
- Hypersensitivity to the drug or other NSAIDs.
Relative (requires special caution because of the risk of complications):
- The presence of dyspeptic symptoms;
- Diseases of the gastrointestinal tract in history;
- Kidney and liver disease;
- Arterial hypertension;
- Heart failure;
- The postoperative period after serious surgical interventions.
Dosing and Administration
Take naproxen should be ingested while eating.
At the beginning of treatment and in acute conditions, adults are prescribed 250-500 mg 2 times a day, in the morning and evening, then 500 mg once a day or 250 mg 2 times a day. With an acute attack of gout, the first intake is 750 mg, then 250-500 mg every 8 hours for 2-3 days.
The daily dose of Naproxen for children is 10 mg per kilogram of body weight. It should be divided into 2 doses with a 12-hour interval.
- Digestive system: epigastric discomfort, nausea and vomiting; in rare cases - abnormal liver function, bleeding, perforation, erosive-ulcerative lesions of the gastrointestinal tract;
- Central and peripheral nervous system: slowing down the speed of psychomotor reactions, headache, drowsiness; in rare cases, hearing impairment;
- Hematopoietic system: in rare cases - aplastic and hemolytic anemia, granulocytopenia, thrombocytopenia;
- Urinary system: in rare cases - renal dysfunction;
- Respiratory system: in rare cases - eosinophilic pneumonia;
- Allergic reactions: urticaria, rash, angioedema.
During treatment, liver and kidney function and peripheral blood picture should be systematically monitored.
In the event that it becomes necessary to determine the concentration of 17-ketosteroids, 48 hours prior to the study, the drug should be discontinued.
During the period of treatment with naproxen, it is recommended to refrain from any potentially dangerous types of work, including driving vehicles.
The drug increases bleeding time.
- Antacids containing aluminum and magnesium, sodium bicarbonate: the absorption of naproxen is reduced;
- Indirect anticoagulants: their effect increases;
- Amoxicillin: possible nephrotic syndrome;
- Probenecid, acetylsalicylic acid: decreases the concentration of naproxen in the blood plasma;
- Diazepam: its pharmacokinetic parameters change;
- Caffeine: increases the effect of naproxen;
- Lithium carbonate: increases the concentration of lithium in the blood plasma;
- Methotrexate: its toxicity may increase;
- Morphine: cases of myoclonus development are known;
- Prednisolone: a significant increase in its plasma concentration is possible;
- Salicylamide: its effect increases;
- Furosemide: its diuretic effect decreases.
Terms and conditions of storage
Store in a dark and dry place.
Shelf life - 3 years.