Methyluracil is a drug that stimulates the process of regeneration and promotes the activation of metabolic processes in tissues and the improvement of trophism.
Release form and composition
Methyluracil is available in the following dosage forms:
- Tablets: white, round, flat-cylindrical, with risk and chamfer (in blister packs or cell-free packages of 10 pcs., 1 or 5 packs in a cardboard pack; in banks of 10, 20 or 50 pcs., 1 bank in a carton pack );
- Ointment for topical and external use of 10% (in aluminum or polyethylene tubes of 25 or 30 g, 1 tube in a carton pack; in banks of 15, 25, 30, 50 or 75 g, 1 bank in a carton pack; contour Cell packs of 50 g, 1 or 2 packs in a carton box);
- Suppositories for rectal use: torpedo-shaped, white with a creamy or yellowish tint or white (in blisters of 5 pieces, 1 or 2 packs in a carton box).
The composition of 1 tablet includes:
- Active ingredient: methyluracil (dioxomethyltetrahydropyrimidine) - 500 mg;
- Auxiliary components: potato starch, calcium stearate, Povidone K30, talc.
The composition of 100 mg ointment for local and external use includes:
- Active ingredient: methyluracil - 10 mg;
- Auxiliary components: ointment base (medical petrolatum, aqueous lanolin) - up to 100 mg.
The structure of 1 suppository for rectal use includes:
- Active ingredient: methyluracil - 500 mg;
- Auxiliary components: the basis for suppositories - in sufficient quantity to obtain a suppository weighing 2190-2410 mg.
Indications for use
Methyluracil tablets are prescribed for the treatment of the following diseases / conditions:
- Leukopenia (in mild, including forms, developed due to x-ray and radiation therapy, chemotherapy of malignant neoplasms);
- Radiation sickness;
- Alimentary toxic Aleikia;
- Agranulocyte angina;
- Reconvalescence (after severe infections);
- Sluggish wounds, bone fractures, burns;
- Peptic ulcer and duodenal ulcer;
- Benzene intoxication.
Methyluracil in other dosage forms is used for the following indications:
- Slow-healing wounds, bone fractures, burns, photodermatitis, pressure sores, trophic ulcers, deep wounds (externally);
- Proctitis, ulcerative colitis, sigmoiditis (local).
Methyluracil is contraindicated to apply in the presence of hypersensitivity to the drug.
Additional contraindications for taking the drug inside are:
- Malignant neoplasms of the bone marrow;
- Leukemia (leukemic forms, especially myeloid);
- Age up to 3 years.
Methyluracil can be used for pregnant and lactating women only after evaluating the benefit / risk ratio.
The drug in the form of ointment is contraindicated in the presence of excessive granulation in the wound.
Dosing and Administration
Methyluracil in pill form is taken orally, preferably during or after a meal.
Dosing regimen is determined by age:
- Adults: 4 times a day, 500 mg (if necessary, the dose rate can be increased to 6 times a day, the maximum daily dose is 3000 mg);
- Children 8-14 years: 3 times a day, 250-500 mg (maximum - 750-1500 mg per day);
- Children 3-8 years: 3 times a day, 250 mg (maximum - 750 mg per day).
The course of treatment of diseases of the gastrointestinal tract is 30-40 days; for other indications, therapy may be shorter.
Methyluracil in the form of an ointment should be applied daily with a thin layer on the damaged areas. The doctor sets the dosing regimen individually. The frequency of dressing changes is determined by the depth and area of the wound surface, the intensity of exudation and the presence of necrotic masses. In the treatment of radioepitheliitis and late radiation injuries of the vagina, ointment is used in loose tampons. In the treatment of acute bullous radiation dermatitis, ulcers, wounds and burns, Methyluracil can be used simultaneously with external applications of sulfonamides, antiseptic and antibiotic agents.
Suppositories for rectal administration are prescribed depending on age:
- Adults: 1-4 times a day, 500-1000 mg;
- Children 8-15 years: 500 mg per day;
- Children 3-8 years: 250 mg per day.
Depending on the indications, the duration of the treatment course can vary from 7 days to 4 months.
When using Methyluracil may develop allergic reactions.
Also during therapy may occur:
- Dizziness, headache, heartburn (when taken orally);
- Short-term slight burning sensation (when applied externally).
Dosage forms of Methyluracil should be used strictly according to appropriate indications.
Methyluracil enhances the anti-ray effect of cystamine.
Terms and conditions of storage
Keep out of the reach of children.
- Tablets - 3 years when stored in a dry, dark place at temperatures up to 25 ° C;
- Ointment for external and local use - 3 years 6 months when stored in a dry place at temperatures up to 20 ° C;
- Suppositories for rectal use - 2 years when stored at temperatures up to 25 ° C.