Metadoxyl is a drug with detoxification, hepatoprotective, nonspecific antidepressant and anxiolytic action, intended for the treatment of alcohol dependence.
Release form and composition
- Tablets: round, convex on both sides, white or almost white in color, on one side - engraving in the form of the name of the drug, on the other - risk (10 pieces in blisters, in a cardboard bundle 1 or 3 blisters);
- Solution for injection: colorless or with a slight yellowish tinge, transparent (5 ml in ampoules of dark glass, 10 ampoules in plastic pallets, in a cardboard bundle 1 pallet).
The active ingredient of the drug is pyridoxine L-2 pyrrolidone 5-carboxylate (metadoxine). In 1 tablet it contains 500 mg, in 1 ml of solution - 6 ml (or 300 mg in 1 ampoule).
Auxiliary components of the tablets: magnesium stearate, microcrystalline cellulose.
Additional substances of the solution: water for injection, sodium edetate, sodium metabisulfite, methyl parahydroxybenzoate.
Indications for use
- Acute alcohol intoxication;
- Alcohol withdrawal syndrome;
- Chronic alcoholism;
- Liver diseases, especially of alcoholic origin (as part of complex therapy).
The use of Metadoxil is contraindicated in pregnant and lactating women, as well as in all patients if they have a known hypersensitivity to the components of the drug.
With caution, the drug should be used in Parkinson's disease if the patient is taking levodopa, since metadoxine reduces its effectiveness.
Dosing and Administration
In acute alcohol intoxication, Metadoxyl is administered intravenously (IV) at a dose of 300-900 mg (5-15 ml of solution) or intramuscularly (IM) at a dose of 300-600 mg (5-10 ml).
When alcohol withdrawal syndrome, the drug is administered as an intravenous infusion at a dose of 900 mg 1 time per day for 3-7 days.
For intravenous administration, Metadoxyl is diluted with 500 ml of 5% glucose solution or an isotonic solution of sodium chloride and injected within 1.5 hours.
In chronic alcoholism and liver disease, the drug is prescribed in oral form: 1 tablet 2 times a day. If necessary, the daily dose is increased to 3 tablets (1 pc. 3 times a day). The duration of treatment is determined individually, but is not less than 3 months. Take the pill should be 15-30 minutes before meals.
Basically, Metadoxyl is well tolerated. In some cases, allergic reactions are noted. With the introduction of the drug in the form of a solution in patients with bronchial asthma may develop bronchospasm.
The composition of the injection solution Metadoxyl includes sodium metabisulfite - a substance that can cause allergic reactions or increase asthma attacks in susceptible patients.
When applied simultaneously with levodopa, metadoxin reduces its effectiveness.
Terms and conditions of storage
Store at temperatures up to 25 ºC. Do not expose to light. Keep out of the reach of children.
Shelf life - 5 years.