Melitor is an antidepressant.
Release form and composition
Melitor is produced in the form of coated tablets (14 pieces in blisters, in a carton pack of 1, 2 or 4 packs).
Active ingredient - agomelatine: 25 mg in 1 tablet.
Indications for use
Melitor is used to treat depressive episodes.
- Lactase deficiency, glucose galactose malabsorption and congenital intolerance to galactose;
- Severe abnormal liver function;
- Elderly patients with dementia;
- Age up to 18 years;
- Pregnancy and lactation;
- Hypersensitivity to the drug.
With care Melitor should be applied in the following cases:
- Mania or hypomania in history;
- Moderate renal dysfunction;
- Elderly age;
- Alcohol addiction;
- The simultaneous use of drugs with a hepatotoxic effect.
During the experiments conducted on animals, agomelatine did not reveal any negative effect on fetal development, however, there are not enough data on the safety of Melitor use in pregnant women, therefore the drug can be prescribed only if there are vital indications, if the expected benefit is higher than the potential risks.
If necessary, the appointment of a drug during lactation, the doctor must decide on the interruption of breastfeeding.
Dosing and Administration
Melitor should be taken orally, swallowing pills whole, washed down with water, at bedtime, regardless of the meal, but in case of undesirable reactions from the digestive system - during the meal.
Usually prescribe 1 tablet per day. If within 2 weeks the therapeutic effect is not sufficiently pronounced, the dose is increased to 2 tablets.
The duration of treatment is determined by the doctor depending on the severity of the disease. The minimum duration of treatment for depression is 6 months.
In most cases, Melitor is well tolerated. Side effects, if any, occur in rare cases and usually disappear on their own within 2 weeks after the start of treatment.
Possible adverse reactions:
- Gastrointestinal tract and liver: abnormal stool, nausea, gastralgia, hepatitis, increased levels of hepatic transaminases;
- Central and peripheral nervous system: visual impairment, headache, causeless anxiety, disturbed sleep and wakefulness, dizziness, migraine, paresthesia, suicidal thoughts;
- Allergic reactions: rash, including erythematous, pruritus, eczema, urticaria;
- Other: back pain, myalgia, asthenia.
After discontinuation of treatment by Melitor, withdrawal syndrome is not observed.
The entire period of therapy should regularly monitor the function of the liver.
Care must be taken when driving and performing potentially hazardous work, requiring speed of psychophysical reactions and / or increased concentration.
With the simultaneous use of drugs that are metabolized with the participation of cytochrome P450 1A2 and CYP 2C9 / 19 enzymes, it is possible to change the pharmacokinetics of agomelatine. You should not appoint Melitor in combination with ciprofloxacin and fluvoxamine. Grepafloxacin, propanolol and enoxacin should be used with extreme caution.
Terms and conditions of storage
Store in a dry place, protected from sunlight and out of reach of children, at temperatures up to 25 ºС.
Shelf life - 3 years.