Xenalten - a drug for the treatment of obesity, an inhibitor of gastrointestinal lipases.
Release form and composition
Xenalten is available in the form of capsules No. 1 with a lid and a blue body, the contents are granules (7 or 21 pieces in blisters, in a carton pack of 1, 2, 3, 6 or 12 packs).
The active ingredient of the drug is orlistat: 120 mg in 1 capsule.
Auxiliary components: sodium carboxymethyl starch (sodium starch glycolate), povidone, microcrystalline cellulose, sodium lauryl sulfate and talc.
The composition of the shell: gelatin, titanium dioxide, blue patented dye.
Indications for use
Xenalten is intended for the treatment of obesity in patients with a body mass index of more than 30 kg / m 2 or more than 28 kg / m 2 in the presence of other risk factors, such as hypertension, diabetes mellitus or dyslipidemia. It is used in combination with a low-calorie diet.
Also, the drug is prescribed to reduce the risk of re-gaining weight after reducing it.
- Malabsorption syndrome;
- Simultaneous use with cyclosporine;
- Age up to 18 years;
- Hypersensitivity to the drug.
With caution Xenalten used in nephrolithiasis and the presence of hyperoxaluria in history.
Dosing and Administration
Xenalten should be taken orally 1 capsule 3 times a day during each main meal or after a meal, but no later than 1 hour.
If the food does not contain fat, then you can skip the drug.
- Gastrointestinal: very often - pain or discomfort in the abdomen, flatulence, loose stools, increased bowel movement, imperative urge to have a bowel movement, oily discharge from the rectum, gas with some discharge (these side effects are usually mild, are transient and occur at the initial stage of treatment (in the first 3 months), their frequency increases in the case of increased fat in the diet, these reactions can be eliminated by better dieting, especially in relation to the amount of dietary intake fat); often - discomfort or pain in the rectum, fecal incontinence, bloating, soft stools, damage to the gums and teeth;
- Respiratory system: very often - upper respiratory tract infections; often - lower respiratory tract infections;
- Nervous system: very often - headaches;
- Urinary tract: often - infections;
- Immune system: rarely - rash, urticaria, pruritus, bronchospasm, anaphylaxis, angioedema;
- Liver and biliary tract: very rarely - hepatitis, increased activity of transaminases and alkaline phosphatase;
- Other: very often - the flu; often - weakness, anxiety, dysmenorrhea.
Before the appointment of Xenaltene, it is necessary to eliminate the organic cause of obesity, for example, hypothyroidism.
During the period of treatment, you need to follow a balanced, low-calorie diet containing no more than 30% of calories in the form of fat, enriched with vegetables and fruits. The daily amount of fat, protein and carbohydrates should be divided into 3 main meals. Since orlistat reduces the absorption of certain fat-soluble vitamins, multivitamin preparations containing fat-soluble vitamins are prescribed to compensate for their deficiency. They must be taken 2 hours before or 2 hours after taking Xenalten.
Reception of high doses - more than 120 mg 3 times a day - does not provide an additional effect.
Xenalten is not intended for use in pediatric practice.
In some cases, when taking orlistat may increase the concentration of oxalate in the urine.
Patients who did not receive vitamin supplements for prophylactic purposes, with two or more consecutive visits to the doctor during the first and second years of drug treatment, showed a decrease in the level of vitamins in the plasma.
Some patients, for example, with bulimia or anorexia, may abuse Xenalten.
Since the absorption of vitamin K may decrease when taking orlistat, in patients who take warfarin for a long time, it is necessary to control blood coagulation parameters.
The induction of drug weight loss can be combined with improved metabolic control of diabetes mellitus, which requires a reduction in doses of insulin or oral hypoglycemic agents (metformin, sulfonylurea, etc.).
If, after 12 weeks of Xenalten use, the reduction in body weight is less than 5% of the initial weight, you should consult with your doctor about the appropriateness of further therapy.
The duration of treatment should not exceed 2 years.
There is no negative effect on the reaction rate, visual acuity and ability to concentrate orlistat.
It is not recommended to prescribe Xenalten to patients taking cyclosporine. If the use of such a combination is still necessary, cyclosporine should be taken 2 hours before or 2 hours after taking orlistat. During treatment, it is necessary to control the content of cyclosporine in the blood plasma.
With the simultaneous use of indirect anticoagulants, incl. warfarin, it is possible to reduce the level of prothrombin and change the values of the indicators of the international normalized ratio (INR), so you need to monitor INR.
The drug is not recommended to be prescribed simultaneously with acarosis, because no data on their pharmacokinetic interactions.
Orlistat reduces the absorption of beta-carotene in food supplements by 30% and inhibits the absorption of vitamin E in the form of tocopherol acetate by about 60%.
If multivitamins are recommended at the same time as Xenical, they should be taken at least 2 hours after taking it or before going to bed.
Orlistat increases the bioavailability, plasma concentration (by 30%) and the hypolipidemic effect of pravastin.
Xenalten may reduce the bioavailability of oral contraceptives. To prevent an unwanted pregnancy during the use of the drug, in the case of the development of acute diarrhea, you should use additional methods of contraception.
Orlistat can reduce the level of amiodarone in the plasma even after a single dose. The use of such a combination is possible only on prescription.
Terms and conditions of storage
Store at a temperature not exceeding 25 ° C in a place protected from light and moisture, inaccessible to children.
Shelf life - 2 years.