Corvalol

Corvalol is a drug that has a sedative and antispasmodic effect.

Release form and composition

• Drops for oral administration, 15, 25, 30 or 50 ml vials, droppers of dark glass, in a cardboard bundle one bottle;
• Tablets, 10 pcs. in blisters, in a carton pack of 2 or 10 packs.

Active ingredients of the drug:

• Α-Bromoisovaleric acid ethyl ester: in 1 ml of drops - 20 mg, in 1 tablet - 8.2 mg;
• Phenobarbital: in 1 ml of drops - 18.26 mg, in 1 tablet - 7.5 mg;
• Peppermint oil: 1.42 mg in 1 ml of drops, 0.58 mg in 1 tablet.

Auxiliary components:

• Drops: ethanol 95%, purified water and sodium hydroxide;
• Tablets: beta-cyclodextrin, lactose monohydrate, potato starch, magnesium stearate and microcrystalline cellulose.

Indications for use

As a vasodilator and sedative:

• Insomnia;

• Irritability;
• Vegetative lability;
• Neurotic states;
• Hypochondriac syndrome.
• Functional disorders of the cardiovascular system (increased blood pressure, cardialgia and sinus tachycardia).

As an antispasmodic:

• Muscle spasm of the gastrointestinal tract (intestinal and biliary colic).

Contraindications

For both dosage forms:

• Severe hepatic / renal failure;
• Lactation period (or should stop breastfeeding);
• Hypersensitivity to the components.

Tablets, in addition, are contraindicated in the following cases:

• Pregnancy;
• Age up to 18 years (experience of using the drug in this dosage form in this age group is absent);
• Lactose intolerance, lactase deficiency, glucose-galactose malabsorption (due to the lactose content).

With extreme caution, Corvalol in the form of drops can be prescribed during pregnancy.

Dosing and Administration

The drug should be taken orally before meals: tablets - squeezed water, drops - dissolving in a small amount of water (30-50 ml).

Adults are prescribed 15-30 drops 2-3 times a day or 1-2 tablets 2 times a day. With tachycardia, a single dose may be increased to 40-50 drops or 3 tablets.

Children, depending on the clinical picture and age, are prescribed for 3-15 drops per day.

The duration of treatment in each case, the doctor determines individually.

Side effects

Possible side effects of Corvalol: dizziness, drowsiness, decreased ability to concentrate, slow heart rate, allergic reactions. In some cases, there are violations of the gastrointestinal tract. The described phenomena disappear at dose reduction or drug withdrawal.

With prolonged use, there is the likelihood of bromine accumulation in the body and the development of bromism phenomena (manifested by symptoms such as conjunctivitis, rhinitis, hemorrhagic diathesis, apathy, depression, impaired coordination of movements), the onset of addiction, drug dependence and withdrawal syndrome.

Overdose symptoms: lower blood pressure, ataxia, nystagmus, agitation, depression of the central nervous system (CNS), dizziness, weakness, bromine intoxication. In this case, Corvalol should be abolished, gastric lavage should be performed, and symptomatic therapy should be carried out; caffeine and niketamide are shown in case of CNS depression

special instructions

During Corvalol treatment:

• You should not drink alcoholic beverages;
• It is recommended to refrain from engaging in potentially hazardous activities, including driving vehicles.

Drug interaction

Drugs that inhibit the central nervous system, and valproic acid enhance the action of Corvalol.

Part of the drug phenobarbital enhances the effect of hypnotic, analgesic and local anesthetics, reduces the effectiveness of drugs metabolized in the liver, including griseofulvin, glucocorticosteroids, coumarin derivatives, oral contraceptives.

Corvalol enhances the toxicity of methotrexate.

Terms and conditions of storage

Store in a dark place, out of reach of children at a temperature of: tablets - 15-25 ºС, drops - up to 15 ºС.

Shelf life of tablets - 2 years, drops - 1.5 years.