Kolhikum-Dispert is a herbal medicine that affects uric acid metabolism. It is used to treat gout.
Release form and composition
Kolhikum-Dispert dosage form - coated tablets (round, dark red, shiny). Available in 20 pieces. in blisters, in a cardboard box 1 blister; 25 each in blisters, in a cardboard box 2 blisters.
The active ingredient of the drug - dry extract of autumn crocus autumn. In 1 tablet it contains 15.6 mg, which corresponds to the content of 0.5 mg of alkaloids (in terms of colchicine).
Auxiliary components: stearic / palmitic acid, magnesium oxide light, corn starch, microcrystalline cellulose, copovidone, sodium carmellose, magnesium stearate, lactose monohydrate, shellac, sodium sulfate, sucrose, macrogol 6000, talc, carnauba wax, titanium oxide, limestone, titanium oxide, copper oxide, titanium oxide, talc, sucrose, macrogol 6000, talc, talc, oxalic acid white wax, gum arabic, cochinear carmine A, amaranth (E123).
Indications for use
- Acute gout attacks;
- Familial Mediterranean fever.
- Renal / hepatic impairment;
- Marked inhibition of bone marrow hematopoiesis;
- Hypersensitivity to the drug.
Relative (requires special observation during treatment):
- Elderly age;
- Severe dysfunction of the gastrointestinal tract;
- Severe dysfunction of the cardiovascular system.
Dosing and Administration
Kolkhikum-Disperse is taken orally, swallowing the pill whole, squeezed with a sufficient amount of water.
In an acute attack of gout, first take 2 tablets, then 1-3 tablets every 1-2 hours until the pain subsides. The total daily dose should not exceed 8 mg. Repeated use of the drug according to the specified scheme is possible no earlier than after 3 days.
For the prevention of acute attacks of gout Kolkhikum-Dispert prescribed in the first few months of the use of uricosuric drugs - 1-3 tablets daily or every other day. The course of admission is usually 3 months.
Possible side effects of Kolhikum-Dispert: nausea and / or vomiting, diarrhea, stomach pain; rarely, leukopenia (due to a decrease in the number of white blood cells). In the case of long-term treatment, neuropathy and myopathy are possible, less often - alopecia, hypoplastic anemia, agranulocytosis.
After receiving an adult dose of about 20 mg and 5 mg in children, acute intoxication is observed. Chronic poisoning is possible when taking a daily dose of 10 mg for several days by patients suffering from gout.
Approximately 2-6 hours after ingestion of an excessive dose of Kolkhikum, perspiration and burning in the throat and mouth, nausea, difficulty swallowing, thirst, urge to vomit, then vomiting, colic, tenesmus, urge to defecate and urinate. Hemorrhagic and / or mucous-watery diarrhea can cause loss of fluid and electrolytes, with the result that the development of metabolic acidosis, hyponatremia and hypokalemia may occur. Often, patients complain of pain and tightness in the heart area. In the future, there is a decrease in body temperature, pallor, dyspnea, and cyanosis. There is the likelihood of developing tachycardia and hypotension, up to collapse.
Also, due to intoxication, neurological disorders are possible, manifested by decreased sensitivity, seizures and symptoms of paralysis. In the first 3 days due to respiratory paralysis and cardiovascular insufficiency, death may occur.
1-2 weeks after the treatment of intoxication, complete, in some cases, long-term alopecia may occur. Possible violations of the kidneys, liver and lungs. There are cases of blindness.
Treatment of intoxication is symptomatic, aimed at stabilizing the cardiovascular system. An isotonic solution of sodium chloride is injected intravenously with the addition of glucose and electrolytes (mainly potassium) or plasma substitutes. Digoxin is prescribed to maintain myocardial contractility, papaverine, atropine or tanalbin for abdominal cramps, and dexamethasone for elevated pressure of the cerebrospinal fluid, lumbar puncture may be necessary. The use of opiates is contraindicated. In some cases, there is a need for antibiotic therapy, the use of oxygen therapy or artificial respiration.
The entire period of treatment Kolhikum-Dispert requires careful hematological and clinical monitoring.
In the case of the occurrence of severe side effects from the digestive system, reduce the dose or discontinue the drug.
With a decrease in the number of platelets below 100,000 / μl and leukocytes below 3000 / μl, treatment is suspended until the blood picture is normalized.
Negative impact on the rate of reactions and the ability to concentrate Attention Kolhikum does not have.
If necessary, Kolhikum-Disperser can be used in combination with uricosuric drugs and allopurinol.
Possible unwanted interactions:
- Cyclosporine (especially in patients with impaired renal function) - the development of myopathy;
- Cyanocobalamin - a violation of its absorption;
- Deprimating and sympathomimetic drugs - enhancing their effect;
- Non-steroidal anti-inflammatory and drugs that cause myelodepression - leukopenia, thrombocytopenia.
Cytostatics and urinary acidifying drugs reduce Kolhikum-Dispert's anti-gout activity, alkalizing agents increase it.
Terms and conditions of storage
To store in the place protected from light and moisture at a temperature up to 25 ºС. Keep out of the reach of children!
Shelf life - 5 years.