Caffeine

Caffeine is a psychoactive drug.

Release form and composition

Caffeine is released in the form of a solution for subcutaneous administration (1 or 2 ml in ampoules, 5 or 10 ampoules in a carton box).

The composition of 1 ml of the solution includes the active substance: caffeine sodium benzoate - 100, 200 or 400 mg.

Indications for use

• Diseases accompanied by inhibition of the function of the respiratory and cardiovascular systems (including infectious diseases, poisoning with opioid analgesics), as well as the central nervous system;
• Spasms of cerebral vessels;
• Decrease in physical and mental performance;
• Drowsiness.

Contraindications

• Arterial hypertension;
• Increased excitability;
• Glaucoma;
• Organic pathologies of the cardiovascular system (including pronounced atherosclerosis);
• Sleep disturbances;
• Hypersensitivity to the drug.

The drug is contraindicated for use in patients at old age.

Dosing and Administration

Caffeine is injected subcutaneously.

As a rule, the drug is prescribed 2-3 times a day in a single dose:

• Adults - 100–200 mg;
• Children 25-100 mg.

Side effects

During therapy may develop disorders of some body systems:

• Central nervous system: agitation, sleep disturbance, anxiety; with prolonged use may develop addiction;
• The digestive system: vomiting, nausea;
• Cardiovascular system: tachycardia, increased blood pressure, arrhythmias.

special instructions

According to the testimony, the use of caffeine is possible both in the form of monotherapy, and simultaneously with other drugs.

Drug interaction

When Caffeine is used together with certain drugs, undesirable effects can occur:

• Estrogens (hormonal contraceptives, agents for hormone replacement therapy) - an increase in the duration and intensity of caffeine action is possible;
• Sleeping pills and drugs for anesthesia - reducing their action;
• Meksiletin - reduced clearance and increased concentration of caffeine in plasma;
• Acetylsalicylic acid - increase of its bioavailability, speed of absorption and concentration in a blood plasma;
• Metoxen is a reduction in the elimination of caffeine from the body with the possible development of a toxic effect and an increase in its effect;
• Analgesics, antipyretics, salicylamide, naproxen - enhancing their action;
• Ciprofloxacin, enoxacin, pipemidovy acid - a pronounced increase in AUC and a decrease in the clearance of caffeine;
• Adenosine - reduction of increased heart rate and changes in blood pressure, a decrease in vasodilation caused by infusion of adenosine;
• Fluconazole and terbinafine - a moderate increase in the concentration of caffeine in the blood plasma;
• Norfloxacin, pefloxacin, fleroxacin - an increase in AUC and a decrease in caffeine clearance;
• Ergotamine - acceleration of its absorption;
• Ketoconazole - increasing the concentration of caffeine in the blood plasma.

Terms and conditions of storage

Store at temperatures up to 25 ° C out of the reach of children.

Shelf life - 5 years.