Caffeine sodium benzoate is a psychogogic.
Release form and composition
Dosage forms Caffeine sodium benzoate:
- Tablets (6 or 10 pcs. In cell or cell-free blister packs; 6 or 10 pcs. In cell or cell-free contour packs, in a carton pack 1 pack);
- Solution for subcutaneous administration (in ampoules of 1 or 2 ml, 10 pcs. In a cardboard bundle complete with an ampulla knife; in ampoules of 1 or 2 ml, 10 ampoules in a contour plastic packages (pallets), in a cardboard bundle 1 or 2 packs complete with ampoule knife; 1 ml ampoules, 10 ampoules with an ampoule knife in a cardboard box with a cardboard insert for fixing the ampoules;
- Solution for subcutaneous and subconjunctival administration (in 1 or 2 ml ampoules, 10 pcs. Each in a cardboard bundle complete with an ampoule knife; 1 or 2 ml ampoules, 5 or 10 ampoules in blister plastic packaging (pallets), carton box 1 or 2 packs complete with ampule knife).
The active ingredient of the drug is caffeine. Its content in 1 tablet and 1 ml of solution is 100 or 200 mg.
Indications for use
- Diseases accompanied by inhibition of the central nervous system (CNS), functions of the respiratory and cardiovascular systems, including in case of poisoning with narcotic drugs and infectious diseases;
- Decreased mental and / or physical performance, drowsiness;
- Spasms of cerebral vessels, including migraine;
- Respiratory disorders (idiopathic apnea or intermittent breathing) in newborns, including premature;
- Enuresis in children.
Caffeine sodium benzoate is not prescribed in the following cases:
- Sleep disturbances;
- Increased excitability;
- Organic diseases of the cardiovascular system, including atherosclerosis;
- Severe arterial hypertension;
- Old age.
Dosing and Administration
The drug is taken orally, injected subcutaneously or subconjunctivally.
Adults are usually prescribed at 100-200 mg, children - at 25-100 mg. Frequency of use - 2-3 times a day.
- Central nervous system: anxiety, agitation, sleep disturbance; with prolonged use - addiction;
- Cardiovascular system: arrhythmias, high blood pressure, tachycardia;
- Digestive system: nausea and / or vomiting.
Abrupt withdrawal of caffeine can lead to increased inhibition of the central nervous system, accompanied by drowsiness, fatigue, depression.
The drug can be used as monotherapy or as part of a complex treatment in combination with other drugs.
Caffeine enhances the effect of antipyretic analgesics, naproxen and salicylamide, reduces the effect of sleeping pills and anesthetics.
Estrogens (hormones and agents for hormone replacement therapy) can increase the intensity and duration of caffeine.
When caffeine sodium benzoate is prescribed to patients receiving adenosine, caffeine reduces the increased heart rate caused by this substance, changes in blood pressure, and vasodilation.
Meksiletin reduces caffeine clearance and increases its concentration in the blood plasma; fluconazole and terbinafine cause a moderate increase in plasma content, ketoconazole is less pronounced.
Caffeine accelerates the absorption of ergotamine, may increase the bioavailability, the rate of absorption and the concentration of acetylsalicylic acid in the blood.
Phenytoin accelerates metabolism and caffeine excretion. Metoxen, on the contrary, reduces its elimination from the body, as a result of which it is possible to enhance the action of the drug and the development of a toxic action.
The most pronounced increases in AUC (pharmacokinetic parameter) and a decrease in caffeine clearance are observed with its simultaneous use with pimemidic acid, ciprofloxacin and enoxacin; less pronounced changes with fleroxacin, norfloxacin, pefloxacin.
Terms and conditions of storage
To store at a temperature up to 25 ºС in the place, inaccessible for children.
Shelf life - 5 years.