Codeine is a natural narcotic analgesic from the group of opiate receptor agonists, which has antitussive, analgesic and antidiarrheal effects.
Release form and composition
Codeine dosage form - tablets.
The active ingredient of the drug is codeine (15 mg in 1 tablet).
Indications for use
- Hot flashes nonproductive cough, including with bronchitis, bronchopneumonia and emphysema;
- Pain in injuries, renal and hepatic colic, cancer;
In combination with sedatives and sedatives can be used as a sedative.
- Bronchial asthma;
- Respiratory failure;
- Impaired liver and kidney function;
- Traumatic brain injury;
- Hypocoagulation state;
- Intoxication diarrhea;
- Alcohol intoxication;
- Pregnancy (especially the first trimester and before childbirth);
- Lactation period (or feeding should be stopped);
- Children's age up to 2 years;
Dosing and Administration
Codeine should be taken orally.
The maximum permissible daily dose is 120 mg.
Recommended doses for adults depending on the indications:
- Pain - 15-60 mg every 3-6 hours;
- Cough - 10-20 mg 4 times a day;
- Diarrhea - 30 mg 4 times a day.
Recommended doses for children:
- Pain - 0.5 mg / kg 4-6 times a day;
- Cough - 10 mg / kg 4–6 times a day;
- Diarrhea - 0.5 mg / kg 4 times a day.
Possible undesirable reactions caused by taking Codeine:
- On the part of the digestive system: constipation, nausea, vomiting, intestinal atony;
- Since the cardiovascular system: arrhythmia, bradycardia, hypotension;
- From the central and peripheral nervous system: headaches, drowsiness; when taken in high doses and in case of hypersensitivity - worsening of coordination of eyeballs with visual impairment, respiratory depression, increased tone of smooth muscles (when taken in doses above 60 mg);
- Allergic reactions: pruritus and rash on the type of urticaria;
- Other: atony of the bladder, weight gain, drug dependence, addiction, withdrawal syndrome.
With prolonged use may develop drug dependence.
Codeine enhances the action of ethanol, clonidine, tranquilizers, opioid analgesics, benzodiazepines, barbiturates, antipsychotics, antihypertensive drugs and anesthesia drugs.
Naltrexone and naloxone are specific antagonists of codeine.
Quinidine significantly reduces or even completely eliminates the analgesic effect of the drug.
When taking codeine in combination with ibuprofen or carbamazepine, it is possible to increase the analgesic action.
With simultaneous use of morphine derivatives, there is a possibility of increasing the inhibitory effect on the respiratory center.
Terms and conditions of storage
Store in a dry, dark place.
Shelf life - 5 years.