Kirin is an antibacterial drug.
Release form and composition
Kirin's dosage form is a powder, from which a suspension is prepared for intramuscular (v / m) administration (in 2-gram vials, in a cardboard pack 1 vial complete with a solvent in a dark glass vial).
The active ingredient of the drug is spectinomycin (in the form of pentahydrate hydrochloride), it contains 2 g of powder in 1 vial.
The composition of the solvent: bacteriostatic injectable water and benzyl alcohol.
Indications for use
Kirin is intended for the treatment of urogenital gonorrhea in women and men.
The use of Kirin is contraindicated in case of hypersensitivity.
Children do not prescribe the drug due to the lack of sufficient data on its safety and efficacy.
Dosing and Administration
A suspension is prepared from the powder for i / m administration. To do this, immediately before injection, 3.2 ml of sterile water is added to the vial and immediately mixed thoroughly. The volume of the resulting suspension is 5 ml, its concentration - 2 g (0.4 g / ml).
The daily dose of the drug for adults - 2 g of spectinomycin (5 ml suspension). Inject it deeply into the muscle into the upper outer quadrant of the buttock 1 or 2 times. If necessary, increase the daily dose to 4 g of spectinomycin (10 ml of suspension).
There are reports that a dose of 40 mg / kg is effective in the treatment of children older than 2 years. In the absence of other effective therapies, Kirin can be used in this dose.
Data on the use of the drug in children under 2 years old no.
Possible side effects from various body systems:
- Central nervous system: dizziness, insomnia;
- Digestive: nausea, increased alkaline phosphatase, cholestatic jaundice;
- Urinary: decrease in diuresis (without dysfunction of the kidneys); in rare cases, hematuria; with prolonged use - a decrease in creatinine clearance, an increase in the level of urea in the blood.
In addition, the following reactions are possible:
- Allergic: rarely - urticaria, spotted erythematous skin rash (sometimes turning into an itchy generalized), anaphylactic reactions;
- Local: pain and induration at the injection site.
With prolonged use of Kirin, changes in laboratory parameters are possible: a decrease in the serum level of glutamine pyruvate transaminases, as well as hemoglobin and hematocrit.
Overdose cases have not been reported to date.
Kirin can be prescribed to patients with impaired renal function only in the event of the failure of other medical treatments.
As a result of dialysis, the level of plasma spectinomycin is reduced by 50%, so the drug should be canceled 24 hours before the session.
Kirin, used for gonorrhea, can mask the symptoms of syphilis. For this reason, in the period of 4-6 weeks, patients should be screened for the presence of the causative agent of this disease. If a disease is suspected, serological testing is carried out for at least 4 months.
It should be borne in mind that during treatment may develop the resistance of gram-negative bacteria Neisseria gonorrhoeae. And although this rarely happens, it is necessary to monitor the clinical efficacy of Kirin in order to detect signs of developing resistance in time.
Adequate and strictly controlled studies on the use of spectinomycin during pregnancy have not been conducted, so the drug can be prescribed, provided that the expected benefits to the woman outweigh the potential risks to the fetus. There is a positive clinical experience in treating gonorrhea in pregnant women at the standard adult dose in case of hypersensitivity to penicillin antibiotics or when gonococci are resistant to other antibacterial agents.
There is not enough experience with Kirin during lactation, so breastfeeding is recommended to stop.
Spectinomycin reduces the clearance of lithium, which increases its effect and toxicity to a clinically pronounced degree. If necessary, the simultaneous appointment of such a combination, you must carefully monitor the level of lithium in the blood plasma and monitor the patient's condition in time to identify the symptoms of toxicity.
Terms and conditions of storage
Store in a dry place at a temperature not exceeding 30 ºС.
Shelf life - 5 years. Ready suspension is not subject to storage.