Kars is a hepatoprotective herbal preparation with an antioxidant effect.
Release form and composition
Karsil dosage form is brown dragee (10 pieces in blisters or blister packs, 8 blisters or packs in a carton box).
The active ingredient of the drug is dry extract of the fruits of the spotted milk thistle (equivalent of silymarin). 1 tablet contains 35 mg.
Auxiliary components: wheat starch, lactose monohydrate, povidone (colidone 25), dextrose monohydrate, talc, sorbitol, magnesium stearate, sodium bicarbonate, microcrystalline cellulose.
Shell composition: acacia gum, sucrose, macrogol (PEG 6000), gelatin, diethyl phthalate, talc, cellulose phosphate, titanium dioxide, glycerol and Broun Opalux dye, consisting of sucrose, purified water, red and black iron oxide, methyl and propyl parahydroxybenzoate.
Indications for use
- Toxic liver damage;
- Chronic hepatitis of non-viral etiology;
- Liver steatosis, including alcoholic;
- Condition after suffering hepatitis;
- Cirrhosis of the liver (as part of complex therapy).
Also, Karsil is prescribed for prophylactic purposes in case of chronic intoxications (including professional), with long-term intake of alcoholic beverages or drugs.
- Children's age up to 12 years;
- Hypersensitivity to the drug.
It is not recommended to apply Kars during pregnancy and during breastfeeding. The drug can be prescribed only in cases of extreme necessity, after assessing the expected benefits and possible risks.
Dosing and Administration
Kars is taken orally before eating, swallowing dragees whole and squeezing water
In severe liver lesions, both adults and children over 12 years old are prescribed 4 tablets three times a day (total dose - 420 mg).
In milder cases and as maintenance therapy, it is enough to take 1-2 tablets three times a day.
For preventive purposes, appoint 1 tablet 2-3 times a day.
The duration of treatment in each case is determined individually, the minimum course is 3 months.
Basically, Carsil is well tolerated. If side effects occur, then in rare cases, they are transient in nature and go away on their own after drug withdrawal.
Possible undesirable reactions caused by the use of Karsil:
- Digestive system: nausea, diarrhea, dyspepsia;
- Allergic reactions: rash, itching;
- Other: alopecia, exacerbation of existing vestibular disorders.
Cases of Karsil overdose were not registered in medical practice. If the patient accidentally took a too high dose of the drug, it is recommended to induce vomiting and do a gastric lavage using activated charcoal. If any reactions occur, symptomatic treatment should be carried out.
During the period of treatment, manifestations of the estrogen-like action of silymarin can be observed, therefore Kars is prescribed with caution in patients with hormonal disorders (women with endometriosis, uterine myoma, carcinoma of the ovaries, uterus and breast, men with prostate carcinoma).
One of the excipients of the drug is wheat starch, so Kars can be dangerous for patients with celiac disease (gluten enteropathy).
Another additional component is glycerol. In high doses, it may irritate the gastric mucosa and / or cause headache.
Karsil may reduce the effectiveness of oral contraceptive drugs and agents used for hormone replacement therapy.
Silymarin may enhance the action of diazepam, alprazolam, ketoconazole, lovastatin, vinblastine.
Terms and conditions of storage
Store in a dry, dark place with limited access by children. The maximum allowable storage temperature is 25 ºС.
Shelf life - 2 years.