Potassium chloride is a drug that replenishes potassium deficiency in the body, corrects metabolic processes, including water-electrolyte balance, which maintains intracellular osmotic pressure.
Release form and composition
Dosage form of potassium chloride - 4% solution for intravenous injection (in 10 ml ampoules, 5 or 10 ampoules per pack).
The active ingredient of the drug is potassium chloride, in 1 ml of its solution contains 400 mg.
Indications for use
- Hypokalemia of various genesis, including due to hyperaldosteronism, diarrhea, vomiting, polyuria in chronic renal failure, as well as taking certain medications;
- Arrhythmia and tachycardia, including during intoxication with cardiac glycosides and diuretics;
- Hypokalemic form of paroxysmal myoplegia.
- Hyperkalemia of various etiologies;
- Complete heart block;
- Impaired renal excretory function;
- Metabolic disorders (hypovolemia with hyponatremia, acidosis);
- Adrenal insufficiency;
- Exacerbation of gastrointestinal diseases.
Patients with impaired AV conduction should be under constant observation during the treatment period.
In pregnancy, potassium chloride is prescribed only if the intended benefit to the mother exceeds the possible risks to the fetus. If you need treatment during lactation, breastfeeding is recommended to stop.
Dosing and Administration
Treatment regimens and dosing regimen in each case are determined individually depending on the severity of the patient’s condition.
The solution is intended for intravenous drip. Pour it at a speed of 20-30 drops per minute.
Basically, the drug is well tolerated.
In some cases, the following symptoms of hyperkalemia are noted: muscle weakness, paresthesias in the lower and upper extremities, confusion, arrhythmias, heart block. In severe cases, cardiac arrest is possible.
When prescribing a solution of potassium chloride in patients with impaired AV conduction, continuous monitoring of the level of potassium in the blood and monitoring of the ECG are necessary. When treating potassium-deficient conditions, acid-base balance should be controlled.
If the solution is introduced too quickly, if there are chronic kidney diseases or any diseases that are accompanied by a violation of potassium, there is a possibility of hyperkalemia, which can potentially lead to death. Early clinical manifestations of this condition (lengthening of the QT interval, lowering of the ST segment, disappearance of the U wave and sharpening of the P wave) are diagnosed, as a rule, at a potassium concentration in the blood of 7-8 meq / l. At a potassium concentration of 9-10 meq / l, more severe symptoms develop, including muscle paralysis, and even at such a concentration, cardiac arrest is possible. It is important to remember that hyperkalemia, which can be fatal, develops quickly and is asymptomatic. In case of an overdose of potassium chloride, intravenous administration or oral administration of sodium chloride solution or IV administration of a dextrose solution (300-500 ml) with a content of 10-20 U of insulin per 1000 ml is indicated. If necessary, conduct peritoneal dialysis and hemodialysis.
The safety and efficacy of using potassium chloride solution in children have not been established
With the simultaneous use of potassium preparations, potassium-saving diuretics, ACE inhibitors, as well as potassium-containing salt substitutes, the risk of hyperkalemia increases.
Terms and conditions of storage
Keep out of reach of children at a temperature of 15-25 ºС.
Shelf life - 3 years.