Isotrexin is a drug for the treatment of acne.
Release form and composition
Isotrexin is produced in the form of a gel for external use in 6, 25, 30, 40 and 50 g.
The active ingredients (per 1 g of gel) erythromycin - 20 mg and isotretinoin - 500 μg.
Excipients: butylhydroxytoluene, ethanol and giproloza.
Indications for use
Isotrexin is intended for the treatment of acne of weak and moderate severity.
Isotrexin is contraindicated:
- When hypersensitivity to the drug;
- At the planning stage of pregnancy;
- Pregnant women;
- During lactation.
In pediatric practice, the drug is not prescribed to children under 12 years.
Dosing and Administration
Isotrexin is used externally.
The product should be applied in a thin layer on previously cleaned and dried skin twice a day - in the morning before applying makeup and in the evening after washing. It is necessary to treat acne and adjacent areas.
The duration of treatment is from 2 to 8 weeks.
In general, isotrexin is well tolerated. In rare cases, a sensation of light tingling, irritation, peeling, burning and redness of the skin at the site of application of the gel is possible at the site of application.
In case of intolerance or hypersensitivity to a particular component of the drug, there is a likelihood of photosensitization and allergic reactions.
Butylhydroxytoluene, which is a component of Isotrexin as an auxiliary component, can cause local reactions (including contact dermatitis), and if it comes into contact with mucous membranes and eyes, it can cause irritation.
Cases of drug overdose have not yet been reported. But given that the gel is intended solely for external use, this is the minimum probability. Accidental ingestion of Isotrexin can lead to the development of symptoms of an overdose of vitamin A, which is manifested, including, severe headache, drowsiness, nausea and / or vomiting, nervousness. Tactics of treatment is selected depending on the degree of intoxication and the clinical condition of the patient.
Excessive use of the drug does not contribute to the rapid and / or better achievement of the result of treatment, but can cause redness and peeling of the skin. If such symptoms have already appeared, it is recommended to stop treatment for several days. But in case of their renewal with continued therapy, Isotrexin should be canceled.
During the application of the gel should avoid contact with the mucous membranes of the mouth, nose and eyes.
Since photosensitivity is one of the side effects of the drug, prolonged sun exposure is contraindicated during treatment.
Isotrexin should not be used simultaneously with agents with keratolytic and / or exfoliative properties, including preparations of the retinoid group.
Isotretinoin can have embryotoxic and teratogenic effects, so women of childbearing age before purchasing this gel should exclude the presence of pregnancy in order to prevent the use of the drug in the early stages. For the same reason, the entire period of treatment is recommended to use reliable methods of contraception.
If possible, it is recommended to avoid the simultaneous use of Isotrexin with oxidizable agents (for example, with benzoyl peroxide), topical glucocorticosteroids and antibiotics of the tetracycline group, since With this interaction, the efficacy of isotretinoin may decrease. If this combination is justified, then the drugs should be applied at different times of the day (for example, one remedy - in the morning, another - in the evening.)
Structural analogues of Isotrexin are not available.
The following drugs belong to the same pharmacological group — Retinoids for the topical treatment of acne — and have a similar mechanism of action:
- Ointment Radevit, Videstim, Radevit Aktiv and Retinoic ointment;
- Solution for external use Retasol;
- Creams Differin and Adaklin;
- Gels Adolene, Adapalen, Deriva C, Klenzit, Differin and Effezel.
Terms and conditions of storage
Keep out of reach of children at temperature up to 25 ºС. Shelf life - 2 years.