Isoprinosine - a drug with immunomodulatory and antiviral effects.
Release form and composition
Isoprinosine is produced in the form of tablets (oblong, white or almost white, with a slight amine odor, biconvex shape, with a risk on one side), 10 pcs. in blisters, 2, 3, 5 blisters in carton packs.
The composition of 1 tablet contains 500 mg of the active substance - inosine pranobex.
Auxiliary components that make up the drug: povidone, mannitol, wheat starch, magnesium stearate.
Indications for use
Isoprinosine is prescribed for the treatment of:
- Flu and other acute respiratory viral infections;
- Infections caused by Herpes simplex type 1, 2, 3 and 4: genital and labial herpes, herpetic keratitis, shingles, chicken pox, infectious mononucleosis caused by Epstein-Barr virus;
- Cory heavy course;
- Cytomegalovirus infection;
- Molluscum contagiosum;
- Human papillomavirus infection: papilloma of the larynx and vocal cords (fibrous type), papillomavirus infection of the genitalia in women and men, warts.
The use of izoprinozin is contraindicated in:
- Chronic renal failure;
- Hypersensitivity to the drug.
The drug is not prescribed:
- Children up to 3 years or with body weight up to 15-20 kg;
- Nursing and pregnant women.
Dosing and Administration
Isoprinosine is taken orally after a meal. Usually, adults and children over 3 years old (with a body weight of 15–20 kg) are prescribed 50 mg / kg per day, the dosage regimen is 3-4 times a day. In severe forms of infectious diseases, the dosage can be individually increased to 100 mg / kg per day, the number of doses up to 6 times a day.
The maximum daily dose is:
- Adults - 3-4 g;
- Children 50 mg / kg.
The duration of therapy in adults and children with acute diseases is usually 5-14 days. Treatment should be continued for 2 more days from the moment the clinical symptoms disappear. Under the supervision of a physician, the duration of treatment, if necessary, can be increased individually.
Treatment of chronic recurrent diseases in adults and children can take several courses of 5-10 days with an interval of 8 days.
With maintenance therapy, the dosage can be reduced to 0.5-1 g per day (1-2 tablets) per month.
In case of herpes infection in adults and children, the drug is usually prescribed for 5-10 days until the symptoms of the disease disappear, in the asymptomatic period, to reduce the number of relapses, take 1 tablet 2 times a day for a month.
Adults with human papillomavirus infection Isoprinosine in the form of monotherapy prescribed 2 tablets 3 times a day, children - 1/2 tablets per 5 kg of body weight per day in 3-4 doses. The duration of therapy is 14-28 days. When recurrent genital warts drug prescribed in the same dosage. It is taken for 14-28 days as monotherapy or in combination with surgical treatment. The course is repeated 3 times at 1 month intervals.
When cervical dysplasia associated with the human papilloma virus, izoprinosine is prescribed 3 times a day, 2 tablets for 10 days, after which the course will be repeated 2-3 times with an interval of 10-14 days.
When using izoprinozin may develop side effects that manifest themselves with different frequencies:
- Nervous system: headache, dizziness, fatigue, feeling unwell (often); nervousness, drowsiness, insomnia (infrequently);
- Musculoskeletal system: joint pain, exacerbation of gout (often);
- Hepatobiliary system: increases the activity of liver enzymes, alkaline phosphatase (often);
- Gastrointestinal tract: loss of appetite, nausea, vomiting, epigastric pain (often); diarrhea, constipation (infrequently);
- Kidneys and urinary tract: polyuria (infrequently);
- Skin and subcutaneous fat: itching, rash (often);
- Other: increases in blood urea nitrogen concentration (often).
Of allergic reactions, the development of maculopapular rash, urticaria and angioedema is most likely.
Isoprinosine should be taken with caution simultaneously with diuretics, xanthine oxidase inhibitors, zidovudine, as well as in acute renal failure.
The drug for acute viral infections is most effective in cases where treatment is started at an early stage of the disease (preferably from day one).
Since Izoprinozin is excreted in the form of uric acid, with prolonged use, it is recommended to periodically monitor the concentration of uric acid in urine and serum. Patients with a significantly increased concentration of uric acid in the body can simultaneously take medicines that reduce its concentration. Also, control is necessary while taking Isoprinosine with kidney-impaired drugs and drugs that increase the concentration of uric acid.
The drug is used with caution in patients with acute liver failure, since it is metabolized in the liver. In this regard, patients with liver failure need to monitor every 2 weeks the content of uric acid in the urine and serum. With long courses of treatment, it is recommended to monitor the activity of liver enzymes every month.
During therapy, it is necessary to take into account that immunosuppressants weaken the immunostimulating effect of the drug.
Patients involved in driving or performing other potentially hazardous work should be aware that Isoprinosine may cause dizziness and drowsiness.
Analogues of Isoprinosine are:
- According to the active substance - Groprinosin;
- According to the mechanism of action - Alloferon, Algirem, Arpeflu, Vectavir, Virolex, Gerpinat, Interferon Alfa-2 human recombinant, Yodantipirin, Midantan, Rimantadine and other antiviral agents.
Terms and conditions of storage
Keep out of reach of children at temperature up to 25 ° C.
The shelf life of the drug is 5 years.