Indinol is a selective estrogen receptor modulator; non-hormonal dietary supplement that has anti-estrogenic and anti-proliferative effect, which is a universal corrector of pathological hyperplastic processes in the tissues and organs of the female reproductive system (breast, cervix, ovaries, endometrium and myometrium).
Release form and composition
The drug is available in the form of hard gelatin capsules of two types:
- Indinol (10 pieces in a blister, 3 blisters in a package; 60, 90 or 120 pieces in a polymer barges);
- Indinol Forto (20 pieces in a blister, 3 or 6 blisters in a package; 60, 90 or 120 pieces in a polymer barges).
The active ingredient is indole-3-carbinol, a substance obtained by extraction from cruciferous plants. It contains 100 mg in Indinol (300 mg is indicated on the package, but 300 means the total weight of the capsule, but not the content of the active substance), in Indinol Forto - 200 mg.
Additional components: modified corn starch, lactose monohydrate, microcrystalline cellulose, magnesium stearate.
Indications for use
Indinol is a drug intended for the pathogenetic and anti-relapse therapy of hyperplastic processes in the tissues of the breast and other estrogen-dependent organs. Being a source of indole-3-carbinol, Indinol normalizes estrogen levels and suppresses their negative stimulating effect, blocks other hormone-independent mechanisms that activate abnormal cell growth in the tissues of the breast and uterus, causes selective cell death with abnormally high proliferative activity, and stimulates the development of healthy cells .
Due to these properties of indole-3-carbinol, Indinol is used for:
- Treatment of cyclic mastalgia, including for benign breast hyperplasia;
- Treatment and prevention of fibrocystic mastopathy;
- Correction of functional disorders in the breast caused by mastopathy.
As part of a complex therapy, a bioadditive is recommended to be taken in case of diseases of the genital area in women caused by the human papillomavirus, including intraepithelial cervical neoplasia and anogenital condylomatosis.
In combination with Epigallat, Indinol is prescribed for uterine myoma, adenomyosis, endometrial hyperplasia (without atypia), endometriosis, and also for the prevention of recurrence of these diseases after their surgical treatment.
Indinol is contraindicated:
- Children and teenagers under 18;
- Pregnant women;
- While breastfeeding;
- With hereditary intolerance to galactose, lactase deficiency, glucose-galactose malabsorption (as part of lactose);
- Simultaneously with drugs that reduce the acidity of gastric juice;
- In case of hypersensitivity to the drug.
Dosing and Administration
Take a dietary supplement should be with meals. As a rule, 200 mg of indole-3-carbinol (2 capsules Indinol or 1 capsule Indinol Forto) are prescribed twice a day.
The course of treatment for fibrocystic mastopathy is 6 months.
For diseases of the genital sphere associated with human papillomavirus, indinol (in the same dose) is prescribed in combination with immunomodulators. Treatment should be given to both sexual partners. The duration of treatment is 3-6 months.
In uterine myoma, adenomyosis, endometrial hyperplasia without atypia, Indinol endometriosis (in a similar dosage) is prescribed in combination with Epigallat (also 2 capsules twice a day). To take the drug for medicinal purposes should be within 6 months, to prevent their recurrence - for 3 months.
According to the data of preclinical and clinical studies, when taking Indinol in therapeutic doses, the drug is generally well tolerated.
In individual cases are possible:
- Disruption of the menstrual cycle;
- Epigastric pain;
- Reducing the concentration of creatinine, eosinophilia, increased levels of prolactin, estradiol, follicle-stimulating and thyroid-stimulating hormones.
It should be noted that the number of patients with adverse events from women who received placebo differs only slightly - 26.9% for indinol and 20.0% for placebo. All identified side effects were mild and mostly took place on their own, in some cases it was necessary to prescribe symptomatic therapy.
In case of an overdose of indole-3-carbinol, nausea, vomiting and diarrhea appear. There is no specific antidote. Treatment is symptomatic.
BAA Indinol is not a medicine. Before use, a medical consultation is required!
Indole-3-carbinol affects the activity of cytochrome P450 isoenzymes, thus Indinol should be used with caution in patients taking drugs, metabolism involving these isozymes - with antiarrhythmics, oral hypoglycemic and antiepileptic drugs, indirect anticoagulants, corticosteroids, digitalis drugs and sex hormones (may require dose adjustments).
According to the active substance, Indinol analogues are Indol-3-carbinol, Indogrin, Hypotrilon, Indole Forte.
The drugs Brest Care, Biolift, Buplerum plus, Mastofit Evalar, Female doctor, Femwell, Evista, Herbal tea Nikafolinka, Epigallat, Epigalin, Estrovel, Estrovel Time-Factor are characterized by a similar mechanism of action.
Terms and conditions of storage
Indinol shelf life - 2 years. Capsules should be stored in a dark, moisture-proof place at temperatures up to 25 ºС.