Imovan is a hypnotic drug from the group of cyclopirrolones with a sedative, anticonvulsant, tranquilizing and muscle relaxant effect.
Release form and composition
Imaovan is produced in the form of coated tablets (10 or 20 pieces in a blister, 2 or 1 blisters per package, respectively).
The active ingredient of the drug is zopiclone, in one tablet contains 7.5 mg.
Auxiliary components: titanium dioxide (E171), lactose monohydrate, magnesium stearate, hypromellose, wheat starch, calcium hydrogen phosphate dihydrate, sodium carboxymethyl starch (type A).
Indications for use
Imov is applied at:
- Transient, situational and chronic insomnia;
- Difficulty falling asleep;
- Night and early awakenings;
- Secondary sleep disorders caused by mental disorders.
Imov is contraindicated in:
- Severe liver failure;
- Severe myasthenia;
- Sleep apnea syndrome;
- Severe respiratory failure;
- Under the age of 18;
- Pregnancy and breastfeeding;
- Hypersensitivity to zopiclone or any auxiliary component of the drug.
Dosing and Administration
Imaovan should be taken orally on 1 tablet at bedtime.
Patients with renal and chronic pulmonary insufficiency, the elderly and patients with impaired liver function reduce the dosage to 3.75 mg of zopiclone (1/2 tablet Imovan). And only in case of insufficiency of the effect, but under the condition of good tolerability of the drug, the dose is increased to 7.5 mg (one whole tablet).
The maximum permissible daily dose is 15 mg.
The duration of treatment for transient insomnia - 2-5 days, with situational - 2-3 weeks, with chronic - is determined individually.
For secondary sleep disorders caused by mental disorders, the doctor determines the dosage and duration of use separately for each patient.
If possible, treatment should be carried out with courses of no more than 4 weeks to prevent the development of dependence. If there is a need for long-term administration of Imovan, an increase in the duration of treatment is possible only after re-evaluating the patient’s condition.
To stop therapy, especially long, it is recommended by gradual decrease in a dose.
Most often, patients complain of a bitter and metallic taste in their mouths.
In some cases, the following side effects occur:
- On the part of the digestive system: dyspeptic disorders, dry mouth, nausea, a slight increase in liver transaminase activity;
- From the side of the central nervous system: dizziness, fatigue, depressed mood, lethargy, headache, hallucinations, anterograde amnesia, impaired coordination, irritability, confusion, nightmares, confusion, depression, inappropriate behavior, aggressiveness;
- Allergic reactions: rash, itching, angioedema, anaphylactic reactions.
In the case of prolonged use of IMOVAN and / or in high doses, there is a risk of developing drug dependence. After discontinuation, withdrawal may occur, manifested by rebound insomnia, agitation, anxiety, excessive sweating, tremor, headache, tremors, confusion, delusions, nightmarish dreams, hallucinations, irritability and tachycardia.
If the therapeutic dose of Imovan is significantly exceeded, CNS depression of various degrees is possible - from drowsiness, apathy and confusion to ataxia, arterial hypotension, respiratory depression and coma. As a rule, an overdose of zopiclone does not constitute a serious threat to life, but only if the person did not take at the same time any other means that depress the central nervous system, including alcohol. Risk factors are comorbidities and a weakened condition of the patient - although they are extremely rare, they can be fatal. If a person accidentally or deliberately takes too high a dose of Imovan, it is recommended to do a gastric lavage as soon as possible, give him an absorbent and call an ambulance. Hemodialysis is practically ineffective. Overdose treatment is symptomatic, special attention is paid to the maintenance of the respiratory and cardiovascular systems. In case of marked inhibition of the CNS, flumazenil may be prescribed.
When using IMOVAN, it is forbidden to consume alcoholic beverages containing ethanol and psychotropic drugs. It is recommended to refrain from driving vehicles and performing potentially hazardous activities.
In some cases, anterograde amnesia develops, especially when sleep is interrupted and in the case of a large period of time between taking the drug and going to bed. For this reason, it is necessary to take a pill immediately before bedtime, while it is highly desirable to ensure that for at least 6 hours nothing interferes with sleep.
Imovan reduces the effectiveness of trimipramine, increases the inhibitory effect on the central nervous system of neuroleptics, hypnotics, tranquilizers, sedatives and antiepileptic drugs, antidepressants, opioid analgesics, anesthetics, erythromycin and antihistamines with a sedative effect.
Increasing zopiclone in plasma is possible with simultaneous use of CYP3A4 isoenzyme inhibitors (ketoconazole, ritonavin, clarithromycin, erythromycin), a decrease in blood - when taking inducers of CYP3A4 isoenzyme (phenytoin, phenobarbital, rifampicin, karabamazepine).
Imov may mask the symptoms of depression.
Structural analogues of Imovan are Somnol, Piklodorm, Slipwell, Thorson, Zopiclone, Relaxax.
The same pharmacological group includes the same effect as Oniria, Andante, Hypnogen, Zolpidem, Snovitel, Zonadin, Ivadal, Sanval, Nitrest, Zolsana.
Terms and conditions of storage
Imovan is sold only by prescription.
Tablets should be stored in their original packaging at a temperature up to 30 ºC in a dark and dry place. Shelf life - 3 years. Keep out of the reach of children!