Chorionic gonadotropin is a gonadotropic drug with a predominantly luteinizing effect, promoting ovulation and the formation of the yellow body in women and stimulating the interstitial cells of the sex glands in men and enhancing testosterone production. The drug also activates the development of genital organs, contributes to the descent of the testicles with cryptorchidism.
Release form and composition
Gonadotropin is produced in the form of a lyophilisate for preparing a solution, the main active ingredient of which is chorionic gonadotropin 500 or 1000 U.
The drug is available in vials complete with a solvent (0.9% isotonic sodium chloride solution) in ampoules. Packaging contains 5 sets of lyophilisate with a solvent.
Indications for use
According to the instructions, chorionic gonadotropin is used in men and women with reduced functions of the sex glands caused by disorders in the pituitary and hypothalamus, namely:
- With anovulatory ovarian dysfunction and related infertility;
- In interstitial pituitary insufficiency (Sheehan syndrome, Simmonds disease, panhypopituitarism, adiposogenital dystrophy, hypogonadotropic hypogonadism with signs of eunuchoidism, pituitary dwarfism with signs of sexual infantilism);
- With habitual and threatened abortion in the first trimester of pregnancy;
- With late sexual development;
- With dysfunctional uterine bleeding in the child-bearing age;
- For the differential diagnosis of hypogonadism (primary and secondary) in men;
- Unilateral cryptorchidism after surgery in the presence of signs of eunuchoidism;
- Bilateral cryptorchidism in children.
According to the instructions, chorionic gonadotropin is not used when:
- Pituitary tumors;
- Hormonally active tumors of the gonads;
- Inflammatory diseases of the sexual sphere;
- Absence of sex glands;
- Early onset of menopause;
Dosing and Administration
Lyophilisate is intended for preparation of solution for intramuscular administration.
The dosage of gonadotropin is usually 500-3000 IU per day.
In the absence of ovulation, women are prescribed 3000 IU, starting from 10-12 days of the menstrual cycle, 2-3 times with an interval of 2-3 days, or every other day, 1500 IU 6-7 times.
Men Gonadotropin prescribed 2-3 times a week for 4 weeks. Within 6-12 months, 3-6 such courses are conducted with breaks of 4-6 weeks.
When conducting diagnostic procedures, the drug is prescribed for 1500-3000 IU per day for 5 days.
With cryptorchidism in children aged 10 years, gonadotropin is prescribed in the amount of 500-1000 U, 2 times a week for 4-6 weeks; in children aged 10-14 years - 1500 IU 2 times a week for 4-6 weeks.
When pituitary nanism with signs of sexual infantilism, the drug is prescribed 1-2 times a week for 500-1000 IU for 1-2 months with repeated treatment course.
When using chorionic gonadotropin, adverse reactions may develop in the form of:
- Allergic reactions;
- Enlarged testicles in the inguinal canals;
- Premature puberty (with long-term therapy or treatment with high doses of the drug in adolescence with disorders of sexual and physical development);
- Atrophy of the seminiferous tubules (due to inhibition of FSH production after stimulation of the production of estrogens and androgens);
- Degeneration of the genital glands (with unjustifiably long-term drug treatment for cryptorchidism, especially if the patient is shown surgery);
- Reduce the number of sperm (with the abuse of gonadotropin).
When using chorionic gonadotropin, it should be borne in mind that:
- In women, drug administration is stopped when the ovarian hyperstimulation syndrome develops;
- Prolonged use of the drug is not recommended because of the risk of inhibition of the gonadotropic function of the pituitary gland;
- The drug is used cautiously in puberty in male patients, in patients with arterial hypertension, coronary heart disease, renal failure, migraine, bronchial asthma;
- An overdose of the drug may manifest ovarian hyperstimulation syndrome and an increase in their size in women;
- Breastfeeding at the time of treatment with the drug should be discontinued.
Analogues of chorionic Gonadotropin are drugs such as Pregnil and Choragon.
Terms and conditions of storage
Chorionic gonadotropin should be stored at a temperature not exceeding 20 ° in places with limited access of children no more than four years.