Glutoxim is an immunomodulator that has a systemic cytoprotective effect.
Release form and composition
Dosage form Glutoxim - solution for injection.
The basis of the drug is glutamyl-cysteinyl-glycine disodium. In one 1 ml of its solution contains 10 or 30 mg. It is sold in 1 and 2 ml ampoules, i.e. with the content of the active component in one ampoule at a concentration of 10, 20, 30 or 60 ml. 5 ampoules are packed in one package.
Auxiliary (inactive) substances of Glutoxim are acetic acid diluted to pH 6.0, sodium acetate, and injectable water.
Indications for use
In accordance with the instructions to Glutoxim, the drug is intended for:
- Treatment and prevention of secondary immunodeficiency states associated with infectious, chemical and radiation factors;
- Increasing the body's resistance to the effects of various factors (infections, radiation, intoxication, etc.);
- Prevention of exacerbations of chronic hepatitis in tuberculosis patients undergoing anti-tuberculosis therapy;
- Treatment of drug-resistant tuberculosis;
- Recovery of the oppressed state of bone marrow hematopoiesis, as well as suppressed immune reactions;
- Treatment of toxic complications resulting from anti-TB therapy;
- Enhancing the therapeutic effect of antibacterial therapy of chronic obstructive pulmonary diseases;
- Prevention of postoperative purulent complications;
- Therapy of chronic viral hepatitis B and C (as a hepatoprotector).
As part of complex therapy, Glutoxim is used in the treatment of:
- Severe common forms of tuberculosis of various localization;
- Uncomplicated forms of psoriasis, including guttate and exudative forms, as well as arthropathic psoriasis and psoriatic erythroderma;
- Malignant neoplasms (for the prevention and elimination of toxic manifestations of radiation and chemotherapy).
In addition, during antitumor therapy, Glutoxim effectively restores the function of bone marrow hematopoiesis, eliminates or at least reduces the severity of nonspecific disease syndrome (symptoms such as fatigue, increased pain sensitivity, anemia, loss of appetite).
Glutoxim use is contraindicated:
- During pregnancy;
- Breastfeeding women;
- In case of hypersensitivity to the drug.
Dosing and Administration
According to the instructions to Glutoxim, the drug is intended for intravenous, subcutaneous and intramuscular administration. The daily dose depends on the severity of the disease and can vary between 50-300 mg.
To increase the body's resistance, to potentiate the therapeutic effect of antibacterial therapy, and also for prophylactic purposes, the solution is administered intramuscularly at a dose of 5-10 mg / day. Duration of Glutoxim - 2 weeks.
As part of the complex therapy of tuberculosis, the drug is administered intramuscularly at a daily dosage of 60 mg: the first 10 days daily, the next 20 days every other day. If necessary, after a break (from 1 to 6 months), a second course of treatment is carried out.
In the complex treatment of uncomplicated forms of psoriasis, the drug is used intramuscularly at a dose of 10 mg: the first 15 days - daily, the next 5 weeks - twice a week. With drop-shaped, exudative, arthropathic psoriasis, as well as with psoriatic erythroderma, Glutoxim is prescribed at a dosage of 30 mg daily for 15 days, over the next 5 weeks at the same dose twice a week. A course of psoriasis therapy of any form consists of 25 injections.
As an aid to patients undergoing chemotherapy in oncology, Glutoxim is prescribed in a dose of 60 mg. Enter it subcutaneously for 1.5-2 hours before the use of anticancer drugs. Between courses in the same dosage, the drug is recommended to be administered every other day. The same schemes are shown in subsequent courses of chemotherapy.
As an aid to patients undergoing radiation therapy in oncology, Glutoxim is prescribed in a dose of 60 mg. It is administered subcutaneously 30–60 minutes after each irradiation session and at the same dosage one day between sessions.
According to the instructions, the drug is mainly well tolerated. In some cases, there is a slight increase in body temperature (up to 37.1-37.5ºC). Some patients complain of pain at the injection site. To reduce its severity, Glutoxim can be administered simultaneously with a 0.5% solution of procaine or novocaine (in the amount of 1-2 ml).
When combined, Glutoxim potentiates the action of chemotherapeutic agents (rifampicin, isoniazid, cycloserine, levofloxacin, rifabutin, capreomycin, cationic antimicrobial peptide catalecidin on Mycobacterium tuberculosis).
If necessary, Glutoxim can be administered in an aqueous syringe with water-soluble drugs.
Glutoxim has no structural analogues. A similar mechanism of action is characterized by a very large list of drugs, among them: Actinolizat, Anaferon, Arpeflu, Affinoleukin, Bioaron C, Vitanam, Vilozen, Wobenzym, Gepon, Deoksinat solution, Zadaksin, Immunal, Immunorm, Immunomax, Imunofan, Imuron-Saint-Max-Imoxon-Im-Max. , Sodium deoxyribonucleate (Derinat), Methylurail, Mozobayil, Sodium nucleinate, Neuroferon, Poluden, Pyrogenic, Polymuramil, Rexod liofilizat, Ruzam, Ribomunil, Taktivin, Stemokine, Uro-Vaxom, Timacidus, Cyclope, I, and I, too, I am happy. , Erbisol, En istol.
Terms and conditions of storage
You can buy Glutoxim only with a prescription prescribed by your doctor.
According to the manufacturer’s recommendations, ampoules should be stored in a dark place at temperatures up to 25 ºC. Under these conditions, the shelf life of the solution is 3 years.