Glutargin is a drug used to treat diseases of the liver and biliary tract.
Release form and composition
Glutargin is released in the form of white round tablets, in blisters of 10 pieces.
One tablet contains 0.25 g of arginine glutamate and excipients - potato starch and calcium stearate.
Also released solution Glutargin in the form of a clear colorless liquid, in ampoules of 5 ml.
Each of them contains 40 mg of arginine glutamate and an excipient - up to 1 ml of water for injection.
Another dosage form of Glutargin is a colorless transparent concentrate for preparing a solution for infusion. It is produced in 5 ml ampoules. One ampoule contains 400 mg of arginine glutamate.
Indications for use
Glutargin is prescribed in cases of:
- Prevention of alcohol intoxication;
- Chronic and acute hepatitis of various etiologies (as part of complex therapy);
- Accompanying hyperammonemia of hepatic encephalopathy, precoma and coma;
- Cirrhosis of the liver;
- Hepatotropic poisons;
- The state of acute alcohol poisoning mild and moderate;
- The hangover;
- Post-intoxication disorders caused by alcohol intake.
The drug is not prescribed to children under 18 years of age. The use of Glutargin is contraindicated in case of hypersensitivity to the components included in its composition, as well as during pregnancy and during the breastfeeding period.
With caution, the drug is prescribed to patients with increased excitability, severe violations of the filtration function of the kidneys and fever.
Dosing and Administration
Tablets are taken orally, regardless of the meal. Dosage means 1-3 tablets three times a day for 2-3 weeks.
In cases of alcohol poisoning, 1-1.5 tablets are prescribed four times a day, taken every 1-2.5 hours. On the second and third day of treatment, patients take 1 pc. twice a day.
In severe alcohol poisoning, Glutargin is administered intravenously. Further, after a course in / in use, appoint 1 tablet twice a day for 20 days. For the prevention of alcohol intoxication is recommended for 1-2 hours before taking alcohol, take 2.5 tablets.
Glutargin's solution is administered intravenously (streamed or drip) or taken orally. Before use, 2 g of the product should be diluted with 150-250 ml of 0.9% sodium chloride solution. The duration of therapy varies within 5-10 days.
In most cases, the drug is well tolerated by patients. The instructions to Glutargin indicate that in rare cases, taking the drug may cause nausea and a feeling of mild discomfort in the epigastric region.
Symptoms of an overdose of the drug are allergic reactions, nausea, insomnia, vomiting, pain in the chest, AV blockade, a short-term decrease in blood pressure and a feeling of discomfort in the epigastric region.
In such cases, the appointment of symptomatic therapy and, if necessary, antihistamines. In severe cases, intravenous glucocorticosteroids are required.
When using Glutargin, patients with impaired endocrine glands should take into account that the drug may slightly increase the secretion of growth hormone and insulin.
The drug does not affect the ability to drive motor vehicles and complex mechanisms.
The drug weakens the effect of vinblastine, may enhance the effect of antiplatelet drugs, weakens and prevents neurotoxic effects that occur during isoniazid therapy.
It should also be borne in mind that aminophylline under the influence of Glutargin increases the concentration of endogenous insulin in the blood.
A synonym for the drug is Glutargin Alcoquline. Glutargin's analogues include Metrop GP, Rosilimarin, Laennec, Karsil, VG-5, Methionine, Orniletex, Gepaphor, Kriomelt MN, Phosphogliv, Cholenol, Tykveol and Silimar.
Terms and conditions of storage
In accordance with the instructions, Glutargin should be stored in a dark, dry and out of reach of children, at a temperature not exceeding 25 ° C.
From pharmacies, the drug is released on prescription. The shelf life of tablets, subject to the recommendations of the manufacturer, is two years. Glutargin cannot be used after the expiration date.