Gliformin - oral hypoglycemic drug.
Release form and composition
Gliformin dosage form - tablets.
The active ingredient of the drug is metformin hydrochloride. Its concentration in a single tablet can be 500 mg, 850 mg, or 1 gram.
Auxiliary components of tablets 500 mg are calcium phosphate dihydrate, sorbitol, povidone (polyvinylpyrrolidone), stearic acid or calcium stearate, macrogol (polyethylene glycol). Implemented in 60 pieces. in cardboard boxes (6 blister packs containing 10 tablets each).
Additional components of Gliformin tablets 850 mg and 1 gram are potato starch, stearic acid, povidone (polyvinylpyrrolidone). In these doses, tablets are sold for 60 pcs. in polypropylene cans.
Indications for use
Gliformin, according to the instructions, is intended for the treatment of diabetes mellitus of the second type especially in patients with obesity. This drug is prescribed in the event that the diet was ineffective.
According to the annotations to the drug, contraindications to the use of Gliformin are:
- Diabetic ketoacidosis;
- Diabetic precoma and coma;
- Extensive surgery, serious injuries and other conditions when insulin therapy is needed;
- Impaired renal function;
- Acute diseases that can lead to impaired renal function: dehydration (including vomiting, diarrhea), fever, severe infections, hypoxia (with renal infections, sepsis, bronchopulmonary diseases, shock);
- Acute alcohol poisoning;
- Chronic alcoholism;
- Lactic acidosis (lactic coma), including a history;
- Observance of a low-calorie diet (when a person consumes less than 1000 calories / day);
- Impaired liver function;
- Acute and chronic diseases that can lead to tissue hypoxia (including acute myocardial infarction, cardiac or respiratory failure, acute cerebrovascular accident)
In addition, Gliformin, according to the instructions, is contraindicated:
- During pregnancy;
- Breastfeeding women;
- When hypersensitivity to metformin or any auxiliary component.
The drug is not recommended to appoint patients over 60 years old who perform heavy physical work, because in this case, the risk of lactic acidosis is high.
Dosing and Administration
The specific dose of Gliformin is determined by the attending physician for each patient individually, taking into account the level of glucose in the blood, the age and severity of the clinical symptoms of the disease.
The initial dose can range from 500 mg to 1 gram of metformin. Take the medicine once a day with food or immediately after a meal. Depending on the level of glycemia, 10–15 days after the start of therapy, the dosage can be gradually increased. The maintenance dose, as a rule, is 1.5-2 grams per day, the maximum allowable is 3 g. In order to reduce adverse effects on the gastrointestinal tract, it is desirable to divide the daily dose into 2-3 doses.
Older people are not recommended to exceed the dosage of 1 g. Reducing the average daily dose is also necessary for patients with severe metabolic disorders, since they have an increased risk of developing lactic acidosis.
The most frequent adverse events that occur when using Gliformin are disorders of the digestive system, namely abdominal pain, flatulence, a metallic taste in the mouth, vomiting, nausea, diarrhea, and lack of appetite. These symptoms usually occur at the beginning of treatment and in most cases disappear on their own. In addition, their severity can be reduced by taking antispasmodics, antacids or atropine derivatives.
In some cases, these side effects are noted Gliformin:
- Metabolism - lactacidosis;
- On the part of the hemopoietic system - megaloblastic anemia;
- Allergic reactions - skin rash and itching.
With prolonged use of Gliformin, hypovitaminosis B12 may develop, while taking the drug in inadequate doses hypoglycemia.
With an overdose of the drug there is the likelihood of developing lactic acidosis, in some cases with a fatal outcome. Another cause of lactic acidosis may be cumulation of metformin due to impaired renal function. Early symptoms of lactic acidosis include nausea, general weakness, vomiting, a decrease in body temperature, diarrhea, pain in the abdomen and muscles, bradyarrhythmia, a decrease in blood pressure. Further, dizziness appears, there is an increase in breathing and impaired consciousness, and coma develops.
In the event of an overdose and the appearance of symptoms of lactic acidosis, Glyformin should be immediately discontinued and the patient should be hospitalized immediately. The most effective method for removing metformin and lactate from the body is hemodialysis. Further, symptomatic therapy is indicated.
In the period of application of Gliformin, it is necessary:
- Abandon the use of alcohol and drugs containing ethanol;
- At least 2 times a year, as well as the appearance of signs of myalgia to determine the content of lactate in the plasma;
- Monitor kidney function: determine serum creatinine every six months.
If necessary, an x-ray or radioisotope study with the introduction of iodine-containing contrast material should stop taking Gliformin 48 hours before the proposed procedure and do not take it for another 2 days after it.
The active substance analogues Gliformin are the following drugs:
- Diaformin OD;
- Nova Met;
- Formin Pliva.
Terms and conditions of storage
Gliformin is a prescription drug.
It should be stored in a dry place inaccessible to the penetration of sunlight, at temperatures up to 25 ºС. With proper storage, the shelf life of tablets 500 mg is 3 years, tablets 850 mg and 1 gram - 2 years.