Glycerol

Glycerin is a drug that has a laxative, softening skin and dermato-protective effect.

Release form and composition

Dosage forms of Glycerol - rectal suppositories, solution for external and local use.

The active ingredient of the drug is glycerol.

Its concentration in suppositories is: in the form of children - 1.24 grams, in the form for adults - 2.11 g. Sodium carbonate decahydrate, polyethylene oxide 400 and stearic acid are used as auxiliary components of rectal suppositories. Suppositories are sold in 5 pcs. in blisters, 2 pcs. in a carton box.

85% Glycerol solution consists of glycerol, purified water is used as an additional component - 15%. Implemented a solution of 25, 40, 50, 60, 70, 80 and 100 g in bottles of dark glass.

Indications for use

According to the instructions for glycerin, the active ingredient of this drug, when applied topically, has a slight irritant effect on the mucous membrane of the rectum, reflexively stimulates peristalsis, and softens the feces. Considering these properties, Glycerin is rectally used to treat constipation of various origins, including psychogenic, functional, age (rectal coprostasis in the elderly), and also due to limited mobility, pregnancy and breastfeeding.

In addition, in the form of suppositories, Glycerin is used to prevent constipation in people who, due to certain circumstances, due to certain diseases, are prohibited from straining and straining during the natural act of defecation. In particular, the drug is prescribed for:

• Perianal abscess;
• Thrombosed, painful hemorrhoids;
• Anorectal stenosis;
• Condition after myocardial infarction (during rehabilitation).

In the form of a solution, glycerin, according to the instructions, has a dermatoprotective effect, and also softens the skin and mucous membranes, therefore it is used for their dryness.

In addition, Glycerin is used as a base for ointments and liniments containing mineral and organic substances soluble in glycerol and water. In particular, it is used as a solvent for borax, boric acid, tannin, protargol, etc.

Contraindications

In the form of suppositories, glycerin is contraindicated in:

• Hypersensitivity to glycerol;
• Inflammatory diseases of the rectum, including proctitis and paraproctitis;
• Anal fissures;
• Exacerbation of hemorrhoids;
• Tumors of the rectum.

Contraindications to external use of Glycerin are hypersensitivity to the drug and violation of the integrity of the skin.

Dosing and Administration

According to the instructions for Glycerin, suppositories should be injected deeply into the rectum once a day, optimally - after breakfast, respectively, adults at a dose of 2.11 g, children - at a dosage of 1.24 g. 2 times a day for 1 candle. The therapeutic effect of the drug is noted already after 20-60 minutes.

The duration of the use of the drug as a laxative is determined by the moment of restoration of normal intestinal motility, however it is important to note that its systematic use is not recommended.

Outwardly and locally Glycerin lubricates dry skin and / or mucous membranes as needed.

Side effects

Based on patient feedback, it can be concluded that in the overwhelming majority of cases the drug is well tolerated and does not have any serious side effects. Nevertheless, it should be noted: the instructions indicate that with prolonged external use of Glycerol there is a likelihood of irritation at the site of application of the solution, and with prolonged rectal use, symptoms of rectal irritation (itching, burning, etc.), as well as weakening physiological process of defecation.

In addition, it is important to note that when a significant amount of the solution is applied by patients who have a condition that promotes increased resorption (including the violation of the integrity of the skin), there is a risk of hemoglobinuria, hemolysis, kidney methaemoglobinovy ​​infarction.

special instructions

The use of Glycerin in the form of suppositories by patients who have had diabetes or dehydration in the past can lead to severe dehydration.

Analogs

Synonymous with glycerin, i.e. preparations with the same active substance are:

• Means for external use - cream Dexeril;
• Laxatives - Glitselaks and Glycerin suppositories, glycerin microclysters.

The same pharmacological subgroup includes the following mechanism of action:

• Laxatives: Zhostera laxative fruits, buckthorn bark, buckthorn syrup, buckthorn extract, Ramnil, Rhubarb tablets, RektivAktiv, Collection of laxative No. 1, Senna leaf, Senna extract, Licorice root powder, Stalnik tincture;
• For external and / or local application: Aktovegin, Alerana, Apropol, Alopeksi, Vaseline, Vulnuzan, Generolon, Dezoksinat, Derinat, Dermaref, Kalanhin, Kamadol, Kosilon, ointment Turmanidze, Melagenin plus Metiluratsil, Piolizin, propolis milk, Propomizol, Propoceum, Revasil, Regein, Redetsil, Reparef, Chamomile extract liquid, Lead water, Silokast, Skin cap, Solcoseryl, Stizamet, Uroderm, Chloroform liniment, Zinocap, Elover.

Terms and conditions of storage

Glycerin is a drug that can be bought on the pharmacy chain on the open market, i.e. A doctor's prescription for his purchase is not needed.

In accordance with the manufacturer's recommendations, this drug should be stored in a place protected from sunlight at a temperature of up to 25 ºС. With proper storage, the shelf life of a solution of glycerin is 5 years, rectal suppositories - 2 years.