Glibenclamide is a drug used to treat type 2 diabetes.
Release form and composition
Glibenclamide is produced in the form of round white tablets, in blisters of 10 pieces. and polymer banks of 50, 60 and 100 pcs. One tablet contains 5 mg of glibenclamide.
Indications for use
Glibenclamide is prescribed to patients with type 2 diabetes mellitus with the ineffectiveness of diet therapy.
Also, the tool is used for daytime glycemic control in combination therapy with insulin.
The use of Glibenclamide is contraindicated in case of hypersensitivity to the components included in its composition, as well as in the following cases:
- Type 1 diabetes;
- Severe renal or hepatic insufficiency;
- Diabetic ketoacidosis;
- Paresis of the stomach;
- Conditions associated with impaired absorption of food and the development of hypoglycemia;
- Pregnancy and during the breastfeeding period;
- Diabetic precoma and coma;
- States after resection of the pancreas;
- Intestinal obstruction.
With caution, Glibenclamide is prescribed to patients suffering from alcoholism, adrenal insufficiency, diseases of the thyroid gland, hypofunction of the anterior pituitary, febrile syndrome, as well as elderly patients.
Dosing and Administration
Tablets are taken orally on an empty stomach half an hour before or two hours after meals. The dosage of Glibenclamide is determined individually, depending on the concentration of glucose in the blood, the severity of diabetes and the age of the patient.
On average, the daily dose of the drug varies in the range of 2.5-15 mg, taken 1-3 times a day.
Most often the drug causes hypoglycemia.
The instructions to Glibenclamide indicated that the drug can cause side effects from the digestive system and blood-forming organs, namely:
- Abdominal pain, nausea, vomiting, belching, hepatitis, diarrhea, a metallic taste in the mouth, a feeling of fullness and heaviness in the stomach, jaundice and a temporary increase in liver transaminase activity;
- Leukocytopenia, pancytopenia, agranulocytosis, thrombocytopenia and hemolytic anemia.
Glibenclamide can also cause the following side reactions:
- Urticaria, angioedema, arthralgia, skin rash, skin flushing, itching, photosensitization and petechiae (allergic reactions);
- Visual impairment and accommodation, disulfiram-like reaction and increased diuresis (other reactions).
In case of drug overdose, hypoglycemia occurs, the symptoms of which are:
- Increased sweating;
- Impairment of consciousness;
- Severe weakness;
- Swelling of the brain;
- Disturbance of speech and vision.
Also, with an overdose of Glibenclamide, hypoglycemic coma may occur.
If the patient is conscious, he needs to ingest sugar. When unconsciousness is injected, dextrose is administered intravenously by bolus, subcutaneously, intramuscularly or intravenously within half an hour - 1-2 mg of glucagon. Further, when the patient regains consciousness, he needs a meal rich in easily digestible carbohydrates.
During the period of Glibenclamide, it is important to regularly monitor blood glucose (fasting and after meals).
Patients should be warned that taking ethanol, NSAIDs, and fasting during drug therapy significantly increase the risk of hypoglycemia.
In cases of physical and emotional overstrain, as well as a change in the dietary regime, a dose adjustment is required.
During treatment with glibenclamide, prolonged exposure to the sun should be excluded.
During the period of use of the tool is recommended to be careful when driving vehicles and complex mechanisms.
The synonyms of the drug are Glidanil, Maniglid and Glimidstad. Glibenclamide analogs include Meglimide, Amaryl, Diabinax, Gliclazide MV, Chlorpropamide, Movogleken, Glimepiride Canon and Glumedeks.
Terms and conditions of storage
In accordance with the instructions, Glibenclamide should be stored in a dark, dry and out of the reach of children, at a temperature not exceeding 25 ° C.
From pharmacies, the drug is released on prescription. The shelf life of tablets, subject to the recommendations of the manufacturer, is two years. Glibenclamide cannot be used after the expiration date.