Hyporamine is an antiviral drug of plant origin, which is active against adenoviruses, various strains of influenza A and B viruses, paramyxoviruses, Varicella zoster, Herpes simplex viruses, cytomegalovirus, respiratory syncytial virus, HIV in the early stages of their development. The drug also has a moderate antimicrobial effect against Mycobacterium tuberculosis, some Gram-positive and Gram-negative bacteria, as well as antifungal activity against Candida and certain mold fungi.
Release form and composition
Hyporamine is produced in the form of ointment, sublingual tablets and a lyophilisate for preparing a solution, the main active ingredient of which is a dry extract of the leaves of the red-backed sea buckthorn.
As excipients in the drug used:
- Ointment - petrolatum, vinylin, polysorbate 80, ethyl alcohol, eucalyptus oil, purified water, emulsifier No. 1, methyl parahydroxycarbonate;
- Tablets - vanillin, cocoa powder, refined sugar, calcium stearate, sodium carboxymethylcellulose.
- Hyporamine ointment is available in 5, 10, and 20 g aluminum tubes; tablets - in blisters and dark glass jars of 10, 20 and 25 pieces; Lyophilisate - in vials.
Indications for use
According to the instructions, hyporamine in the form of tablets is used for the prevention and treatment of:
- Herpes zoster;
- Chicken pox;
- Adenoviral, respiratory syncytial and other acute respiratory viral infections;
- Influenza A and B;
- Angina, which are accompanied by rhinitis and develop on the background of SARS;
- Cytomegalovirus infection;
- Acute and recurrent herpes of genital and extragenital localization.
According to the instructions, hyporamine as an ointment is used for:
- Acute and recurrent herpes, genital and extragenital localization;
- Chicken pox;
- Cytomegalovirus infection.
The lyophilisate is used to prepare a solution for influenza, respiratory syncytial, adenoviral and other viral infections of the upper respiratory tract.
According to the instructions Hyporamine does not apply:
If the patient has individual intolerance to the components of the drug;
At the age of 2 months (ointment) and up to 3 years (tablets).
Dosing and Administration
Hyporamine ointment is intended for topical and external use. It is applied to the affected areas 4-6 times a day. The duration of drug treatment for milder forms of viral diseases is 3-10 days; in the case of a recurrent process and severe forms of disease, the minimum duration of therapy is 14-21 days. Perhaps a repeat of the course of treatment.
Sublingual tablets are intended for oral administration.
The use of Hyporamine tablets should begin in the early stages of the disease.
With shingles, varicella, cytomegalovirus, herpes infection, other viral lesions of the mucous membranes and skin of children over 12 years old and adults, the drug is used 4-6 times a day, one tablet; children aged 3-6 years - 2-4 times a day for half a tablet; children aged 6-12 years - 3-4 times a day, one tablet. The duration of therapy is: for milder forms of the disease - 3-10 days, for severe - 14-21 days.
In case of influenza, parainfluenza, adenovirus, respiratory syncytial and other viral infections affecting the upper respiratory tract Hyporamine in the form of tablets is prescribed:
- Adults - 4-6 times a day, 1 tablet;
- Children over 12 years old - 3-4 times a day, 1 tablet;
- Children 3-12 years old - 2-4 times a day, 0.5-1 tablet.
The duration of treatment for influenza is at least 3 days, for parainfluenza, adenoviral, respiratory syncytial, mixed infections or other acute respiratory viral infections - at least 5 days.
In order to sanitize the oral cavity, sublingual tablets must be kept in the mouth until completely dissolved.
In order to prevent cytomegalovirus and herpes infections in postoperative patients, with immunosuppressive therapy, hyporamine is taken 3 times a day, 1 tablet for 5-7 days.
Lyophilized Hyporamine is intended for the preparation of an aqueous solution, which is obtained by adding sterile distilled water to the vial (10 ml to obtain a 0.2% solution, 20 ml to obtain a 0.1% solution). The solution is used for inhalation.
For influenza, respiratory syncytial, adenoviral and other viral infections of the upper respiratory tract, a 0.1% solution in a volume of 10 ml per inhalation is used for older children, and a 0.1% solution in a volume of 5 ml is used for younger children. for inhalation; for adults, a 0.2% solution in a volume of 10 ml per inhalation is used.
When rhinitis, Hyporamine solution is instilled into the nose: children 2-3 times a day, 2-4 drops of a 0.1% solution, adults 3-4 times a day, 4-6 drops of a 0.2% solution.
When using Hyporamine as an ointment, it is possible that adverse reactions are predominantly allergic.
With long-term use of tablets in excess of the recommended doses may increase blood clotting.
When using Hyporamine as a solution in concentrations of more than 0.2%, irritation of the nasal mucosa may occur.
When applying Hyporamine should be borne in mind that:
- You can use the ointment during pregnancy and lactation after prior consultation with the doctor;
- The therapeutic effect of the ointment is enhanced when it is used in combination with Hyporamine tablets, rectal and vaginal suppositories with Hyporamine, Hyporamine solution;
- One sublingual tablet contains 529.9 mg of sucrose, which is important in the appointment of the drug to patients with diabetes mellitus;
- The drug does not affect the level of concentration and speed of psychomotor reactions, which is important when performing potentially hazardous activities;
- Cases of drug overdose were not recorded;
- The drug can be used simultaneously with other drugs.
Structural analogues of this drug are such drugs as vaginal and rectal suppositories with Giporamin, Sea Buckthorn Berry leafy extract.
Terms and conditions of storage
Hyporamine is stored at a temperature of 15-25º in places not accessible to children, no more than two years.