Hydroxyapatite is a drug that regulates the metabolism of calcium and phosphorus, promotes bone tissue regeneration, and has an anti-inflammatory effect on it.
Release form and composition
Hydroxyapatite is made in the form of granules, suspensions, pastes and powder. The active component of the drug is calcium phosphate, which is produced from corals mined in the sea. It is completely inert to human tissues, due to which it is quite common in oral and maxillofacial surgery, traumatology, and dentistry.
Indications for use
According to the instructions, hydroxyapatite is indicated for use in stimulating re-paratective osteogenesis in plastic and maxillofacial surgery, dentistry and traumatology. So, the drug is used:
- With various fractures;
- With periodontitis;
- In case of wounds, accompanied by damage to the bone tissue;
- As a means to compensate for the lack of elements in the bone tissue;
- When the plastic of the facial bones;
- With the resulting false joints;
- To restore bone defects after removal of sequesters;
- For the introduction of implants and endoprostheses.
Hydroxyapatite as an ingredient of dental filling paste is used to fill the dental canal, as well as when:
- Deep caries;
- Completion of defects after partial removal of the apex of the tooth root;
- Restoration of bone defects after removal of a cyst.
Application Hydroxyapatite received in cosmetology for intradermal injections to smooth wrinkles.
According to the instructions, hydroxyapatite has no contraindications, with the exception of hypersensitivity to the drug.
Dosing and Administration
Before use, Hydroxyapatite powder is mixed with a physiological solution, ethylene glycol, an oil solution of retinol acetate to obtain a homogeneous paste. During the mixing process it is necessary to follow the rules of antiseptics.
To fill the root canals with paste, the medicine is prepared with the addition of eugenol, if it is compatible with filling materials. If not, then Hydroxyapatite is kneaded with a physiological solution. In order to improve the radiopacity, 50% zinc oxide can be added to the mixture. To prevent the development of undesirable complications, the paste with Hydroxyapatite is removed beyond the top of the root of the tooth being processed.
Hydroxyapatite capsules are used for periodontitis in order to fill the bone channels with a depth of more than 5 mm. The specialist prepares the bone pocket during the patchwork operation and fills it tightly with granules until they reach the level of the surviving bone of the alveolar process, after which the wound is sutured.
When removing the top of the root of a tooth or dead bone tissue, the bone pocket is filled with granules in the same way as when using other materials.
The use of hydroxyapatite is common in surgery for bone grafting. It reduces the risk of inflammation, enhances the osteointegrative properties of the graft, does not allow it to quickly dissolve. The drug is filled with uneven surfaces and areas of incomplete fit between the grafts and the bone bed. Sterile powder or granules, diluted with saline to form a thick paste, are placed along the graft with a trowel in places where it is loosely attached, after which the wound is sutured in layers.
You can sterilize Hydroxyopatite an unlimited number of times. To this end, the medicine is placed in a drying cabinet and processed under a temperature of +150 ° C for 10-15 minutes.
Apply Hydroxyapatite in cosmetology for intradermal injections. Before injections, local anesthesia of the area of the skin where the preparation is supposed to be given must be given. After that, the beautician performs the required number of injections of Hydroxyapatite into the deep layers of the dermis.
After injections, a light massage is carried out for a few minutes so that the drug can be evenly distributed in the tissues. The effect is noticeable almost immediately. After the injection for some time you should not steam out the skin and visit the bath.
When hydroxyapatite is introduced into the dermis, it starts the synthesis of new collagen, and when administered under the periosteum, it stimulates the production of osteoblasts (bone tissue cells).
Hydroxyapatite has low toxicity and practically does not cause side effects.
With a significant excess of the dose of the drug (2 g per kg of body weight and more), systemic side effects may occur, caused by an excessive influx of the soluble calcium phosphate fraction into the blood:
- Increased excitability thresholds of the neuromuscular and nervous system.
It is impractical to use hydroxyapatite for the regeneration of bone tissue in the presence of soft tissue inflammation, accompanied by the formation of pus.
Structural analogues of hydroxyapatite has not. Drugs with similar pharmacological effects are:
- Calcium additive;
- Calcium gluconate;
- Calcium Sandoz Forte;
- Calcium Pangamat.
Terms and conditions of storage
According to the instructions, Hydroxyapatite is recommended to be stored in a dry and dark place, at a temperature of 2-30 ° C. The shelf life of the drug is 2 years.