Hydrocortisone - glucocorticosteroid.
Release form and composition
Dosage forms of the drug - suspension for intramuscular and intraarticular injection, 1% ointment for external use, 0.05% eye ointment.
Hydrocortisone is a part of suspension:
- 25 mg hydrocortisone acetate;
- Additional components: sorbitol, propylene glycol, povidone, sodium chloride, benzyl alcohol and water for injection.
1 g of external ointment contains:
- 10 mg hydrocortisone acetate;
- Excipients: pentol, anhydrous lanolin, petrolatum, stearic acid, nipagin (methylhydroxybenzoate), nipazol (propylhydroxybenzoate), purified water.
1 g of eye ointment contains:
- 10 mg hydrocortisone acetate;
- Inactive substances: white petrolatum and methyloxybenzoate.
Indications for use
In the form of injections Hydrocortisone, according to the instructions, is used for:
- Severe bronchial asthma, asthmatic status;
- Allergic reactions (acute and severe forms);
- Toxic, operational, cardiogenic, traumatic and burn shock with the ineffectiveness of other therapies;
- Blood transfusion shock;
- Anaphylactoid reactions;
- Anaphylactic shock;
- Brain edema, including those developed as a result of a brain tumor, surgery, trauma, radiation therapy;
- Thyrotoxic crisis;
- Acute adrenal insufficiency;
- Systemic diseases of the connective tissue, including rheumatoid arthritis, systemic lupus erythematosus;
- Acute hepatitis;
- Hepatic coma.
Outer hydrocortisone, according to the instructions, should be used for:
- Various forms of eczema;
- Simple and allergic dermatitis;
- Diffuse neurodermatitis;
- Red lichen;
- Anogenital itching;
- Insect bites.
Hydrocortisone eye ointment is used in the treatment of:
- Eye diseases of allergic origin, including conjunctivitis, blepharitis, keratoconjunctivitis and eyelid dermatitis;
- Inflammatory diseases of the anterior part of the eye (in the absence of the integrity of the corneal epithelium);
- Thermal and chemical burns of the eye (in the period after the final epithelialization of corneal defects).
For short-term use of Hydrocortisone for "vital" indications, the only serious contraindication is hypersensitivity.
Undesirable intraarticular introduction with:
- Pathological bleeding (endogenous or caused by the use of anticoagulants);
- Infectious (septic) inflammatory process in the joint;
- Intraarticular bone fracture;
- Periarticular infections in the joint, incl. in the anamnesis;
- Common infectious diseases;
- Severe periarticular osteoporosis;
- No signs of inflammation in the joint (with the so-called dry joint, for example, in osteoarthritis without synovitis);
- Aseptic necrosis of the epiphyses of the bones that form the joint;
- Joint instability due to arthritis;
- Pronounced bone destruction and / or deformity of the joint (for example, ankylosis, a sharp narrowing of the joint space).
Outwardly, you should not apply ointment for:
- Violation of the integrity of the skin;
- Bacterial and viral skin diseases;
- Skin tuberculosis;
- Skin tumors;
- Syphilitic skin lesions;
- Perioral dermatitis;
- Acne vulgaris;
Eye ointment is not recommended for:
- Purulent, viral, fungal, and tuberculous diseases of the eye;
- Violation of the integrity of the membranes of the eye.
All hydrocortisone dosage forms are not recommended during pregnancy and lactation. In the first case, the use is possible if the expected benefit to the woman outweighs the potential risks to her baby, in the second case, breastfeeding should be stopped.
Dosing and Administration
Suspension Hydrocortisone is intended for intramuscular and intraarticular administration. For emergency care, intravenous administration is possible.
In each case, the physician selects the specific dosage individually, taking into account the indications and the severity of the patient's condition.
Intramuscularly, the drug is injected deep into the gluteus muscle at a dose of 50 to 1500 mg per day. In acute life-threatening conditions, injections are usually indicated at a dosage of 100–150 mg every 4 hours for the first two days, then at the same dose every 8–12 hours. Children dosage calculated on the basis of weight - from 1 to 9 mg per kilogram of weight.
Hydrocortisone is injected into the cavity of the joints by 5-25 mg (depending on the size of the joint) once a week. The course of treatment usually involves 3-5 injections.
Outwardly, the ointment is applied to the affected areas 2-4 times per day. The dose of the drug used in one week should not exceed 40-60 g. The duration of use of Hydrocortisone is 1-3 weeks.
1 cm of eye ointment is injected into the conjunctival sac of the affected eye 2-3 times a day. Duration of treatment is 1-2 weeks.
When applied topically, Hydrocortisone may irritate the skin.
When using an ointment in ophthalmology, there is a burning sensation, sclera injections, allergic reactions, a short-term violation of the clarity of visual perception.
When the / m and / s the introduction of the solution there are a variety of side effects, including from the cardiovascular, endocrine, digestive, nervous systems, as well as from the senses, metabolism, musculoskeletal system, skin and mucous membranes. The frequency and severity of these reactions depend on the dose of the drug and the duration of treatment.
- Suspensions: Hydrocortisone hemisuccinate, Cortef, Solu-Cortef, Betamethasone, Dexazone, Kenalog, etc .;
- External ointment: Prednisolone, Prednisolone-Ferein;
- Eye ointment: Hydrocortisone-Pos, Dexamethasone, Dexapos, Maxidex.
Terms and conditions of storage
Recommended storage temperature: suspensions - up to 15 ºС, ointments - up to 25 ºС.
The shelf life of the suspension and external ointment is 3 years, eye ointment is 2 years.