Herpesvir is an antiviral drug that is active against herpes simplex type 1 and 2, as well as chicken pox and shingles.
Release form and composition
Make the cream outer Gerpevir, 1 g of which contains the active substance - acyclovir 50 mg. In tubes of 5 or 10 g.
Also make tablets Gerpevir with a content of 0.2 or 0.4 g of acyclovir in 1 tablet. Auxiliary components are: potato starch, calcium stearate, low molecular weight medical povidone. In blister packs of 10 tablets.
Indications for use
According to the instructions, Gerpevir is indicated for use in:
- Infections of the mucous membranes and skin caused by herpes simplex type 1 and 2 (including primary or recurrent genital herpes);
- Prevention of infections of the skin and mucous membranes in immunocompromised patients;
- Chicken pox;
- Shingles (without immunological disorders).
According to the instructions, Gerpevir should not be used for:
- Hypersensitivity to acyclovir or auxiliary components of the drug;
- Impaired renal function.
Dosing and Administration
Tablets Gerpevir apply inside. Treatment should begin when the first symptoms of the disease appear. Children up to 2 years with primary herpes virus infections appoint 0.5 g every 4 hours; over 2 years old - 1 g per day, divided into 5 doses. The duration of therapy is 5-7 days.
Children up to 2 years with chickenpox and shingles are prescribed 0.2 g 4 times a day; 2-6 years - 0.4 g 4 times a day; over 6 years old - 0.8 g 4 times a day. The duration of therapy is at least 5 days.
For primary herpes virus infections, the use of Gerpevir by adult patients is 0.2 g 5 times a day for five days. Immunocompromised patients, including those after organ transplants, bone marrow, and intestinal absorption, should be taken 0.4 g 5 times a day for 5-10 days.
To prevent herpes virus infection with normal immunity, adult patients take 0.2 g of Gerpevir 4 times a day. Allowed to reduce the daily dose of up to 0.6 g, divided into 2-3 doses.
In case of severe immunodeficiency, it is recommended to take the drug at 0.4 g 4 times a day. The duration of therapy with Gerpevir the attending physician sets individually.
With chickenpox and shingles, patients with normal immunity are advised to take 0.8 g 5 times a day for one week.
In case of severe impaired renal function or old age, it is recommended to reduce the dose of Gerpevir depending on the creatinine clearance. The drug is taken under strict medical supervision.
Herpevir cream is applied topically. The drug is applied in a thin layer on the infected skin and the adjacent areas. The multiplicity of application of Gerpevir cream - 4-5 times a day. The average duration of treatment is 5 days. In the case of severe infection, the duration of treatment may be doubled.
For a quick therapeutic effect, it is recommended to start treatment with Gerpevir as soon as possible after infection.
The use of Gerpevir in tablet form can cause the following side reactions:
- Gastrointestinal system: loss of appetite, nausea, vomiting, diarrhea, intestinal colic;
- Nervous system: dizziness, fatigue, headache;
- Allergies: skin rash, swelling, itching, fever;
- Laboratory indicators: deterioration of blood counts, increased levels of liver transaminases, creatinine, bilirubin, urea;
- Other: baldness.
The use of Gerpevir cream can lead to the development of itching, soreness, burning, skin rash, vulvitis after application. It is possible the occurrence of edema at the site of application of the drug.
During pregnancy, the use of the drug is not recommended, except for vital indications. If there is a need for therapy with Gerpevir during lactation, the issue of discontinuing breastfeeding should be resolved.
While taking Gerpevir with:
- Probenecid - its removal is slowed down;
- Nephrotoxic drugs - their nephrotoxic effect is enhanced, especially in cases of renal impairment.
With an overdose of Gerpevir in pill form, symptoms such as nausea, vomiting, headache, and stool disorders are possible. In this case, symptomatic therapy should be carried out. With the development of more pronounced symptoms of overdose (convulsions, renal failure, shortness of breath, coma) it is recommended to call an ambulance.
If Gerpevir is accidentally swallowed, headache, neurological disorders, nausea, diarrhea, lethargy, coma, impaired renal function, vomiting, convulsions, and shortness of breath are not excluded. Treatment involves carrying out activities aimed at maintaining vital functions.
If women with genital herpes does not improve Gerpevir during one week of use, it is recommended to contact your doctor (with genital herpes the risk of developing cervical cancer increases, therefore it is recommended to perform a Papanicolaou test once a year to detect changes in the cervix).
During therapy for genital herpes, sexual intercourse should be avoided.
When using Gerpevir, it is recommended to regularly monitor kidney function (plasma creatinine and urea nitrogen in the blood).
With chickenpox, the greatest effect of treatment will be achieved if the drug is used on the first day after the rash.
Cream Gerpevir should not be applied to the mucous membranes of the eyes and mouth, as it is possible the development of local inflammation.
Structural analogues of Gerpevir are drugs Vivoraks, Gerviraks, Acyclovir, Zovirax, Herpetad, Atsiklostad, Virolex, Atsikerpin.
Terms and conditions of storage
According to the instructions, Gerpevir should be stored in a dark, dry, out of reach of children. The shelf life of the tablets Gerpevir is 3 years, cream - 2 years.