Genferon is a drug with immunomodulatory, antioxidant, antiviral and local anesthetic effects, used in the treatment of inflammatory processes of the genitourinary system.
Release form and composition
Genferon is produced in the form of suppositories, the main active ingredients of which are: recombinant human alpha-2b interferon, benzocaine, taurine.
The following substances were used as auxiliary substances in suppositories: macrogol 1500, solid fat, polysorbate 80, dextran 60,000, sodium hydrocitrate, T2 emulsifier, purified water, citric acid.
Suppositories Genferon produced in a blister pack of 5 or 10 pieces.
Indications for use
According to the instructions Genferon applies when:
- Genital herpes;
- Human papillomavirus infection;
- Recurrent vaginal candidiasis;
- Bacterial vaginosis;
- Cervical erosion;
- Acute bronchitis;
- Chronic bacterial cystitis.
According to the instructions, Genferon does not apply if the patient has an individual intolerance to the components in the preparation.
The drug is carefully prescribed during periods of exacerbations of autoimmune and allergic diseases.
Dosing and Administration
Suppositories Genferon designed for vaginal and rectal use.
- In case of infectious and inflammatory diseases of the urogenital tract in women , 1 suppository is administered vaginally or rectally 1 (depending on the severity of the disease, 250, 500, 1000 thousand IU) 2 times a day for 10 days. In case of protracted diseases, one suppository every other day, 3 times a week for 1-3 months. In the case of a pronounced infectious-inflammatory process in the vagina, the following treatment regimen can be used: 1 suppository 500 thousand IU in the morning vaginally and 1 suppository 1000 thousand IU at night rectally with simultaneous introduction into the vagina of the suppository containing fungicidal or antibacterial;
- In infectious and inflammatory diseases of the urogenital tract in men - rectally one suppository 2 times a day for 10 days;
- To normalize the indices of local immunity during the treatment of infectious and inflammatory diseases of the urogenital tract in pregnant women for periods of 13–40 weeks - 1 suppository of 250,000 IU vaginally 2 times a day for 10 days;
- In acute bronchitis - rectally, 1 suppository of 1,000 thousand IU 2 times a day for 5 days;
- In chronic cystitis in case of exacerbation of the disease - rectal 1 suppository 1000 thousand IU 2 times a day for 10 days simultaneously with antibiotic therapy, then rectally 1 suppository 1000 thousand IU every other day for 40 days.
With the use of Genferon, adverse reactions of an allergic nature may occur in the form of a burning sensation in the vagina, which disappear 3 days after the drug is discontinued.
In addition, there may be: fever, chills, fatigue, loss of appetite, pain in the joints, muscle and headaches, sweating.
With a large excess of the daily dosage of the drug more than 1000 thousand IU, thrombocytopenia and leukopenia may occur.
When applying Genferon should be borne in mind that:
- In order to prevent urogenital reinfection, it is necessary to treat the patient’s sexual partner;
- It is possible to use the drug during menstruation;
- When the temperature rises after drug administration, 500-1000 mg of paracetamol can be taken once;
- In case of accidental administration of suppositories at the same time in an amount much higher than the recommended dosages, it is necessary to suspend treatment for 24 hours and then continue it according to the regimen prescribed by the attending physician;
- The drug is most effective when used simultaneously with drugs for the treatment of urogenital diseases (including antibiotics and other antimicrobial agents);
- The action of benzocaine, which is part of Genferon, is enhanced by non-narcotic analgesics and anticholinesterase drugs;
- Benzocaine, which is part of the drug, reduces the antibacterial activity of sulfa drugs.
The analogue of the drug is Interferon.
Terms and conditions of storage
Genferon is stored at a temperature of 2-8º in places not accessible to children, no more than two years.