Hexamethylenetetramine is a prodrug with dose-dependent disinfecting (antiseptic) and disinfectant properties. In an acidic environment, formaldehyde is released from it, under the influence of which the denaturation of protein structures of microbial cells occurs (the process of cleavage is carried out in the kidneys).
Release form and composition
Hexamethylenetetramine is available in the form:
- Solution for intravenous administration, in 1 ml of which contains 400 mg of methenamine as an active substance;
- Tablets containing 250 or 500 mg of methenamine.
A solution of 40% goes on sale in ampoules of 5 and 10 ml, 10 ampoules in one package.
Tablets Hexamethylenetetramine 250 mg are packaged in packs of 6 pieces, tablets 500 mg - 10 pcs.
Indications for use
According to the instructions to Hexamethylenetetramine, the drug is used in infectious diseases of the urogenital tract, for example, in cystitis (inflammation of the bladder) or pyelitis (inflammation of the renal pelvis and calyx).
The use of Hexamethylenetetramine, according to the instructions, is contraindicated in:
- Hypersensitivity to the components of the drug and, in particular, to methenamine;
- Liver failure;
- Renal failure;
In pediatric practice, according to the instructions, Hexamethylenetetramine is allowed to be prescribed to children over 6 years old.
With caution, the drug should be prescribed to patients who have slowed atrioventricular conductivity.
Dosing and Administration
Tablets are intended for oral administration. It is recommended to take them twice a day. A single dose ranges from 250 mg to 1 gram.
The solution for intravenous administration is prescribed in a dose equal to from 2 to 4 grams of methenamine. The scheme of use of Hexamethylenetetramine, as well as the duration of the course of treatment, the doctor determines individually for each patient, taking into account the clinical situation.
According to the annotation to the drug, Hexamethylenetetramine can cause the following side effects:
- Disorders of the digestive tract, which are expressed in the form of diarrhea, nausea, vomiting, pain in the epigastric region;
- Allergic reactions that are most often manifested by skin rashes and itching;
- Disorders of the urinary organs, expressed in the form of crystalluria (the appearance of salt crystals in urine), albuminuria (an increase in urinary protein excretion), hematuria (presence of blood in the urine);
- Local reactions: the most frequent are hyperemia, swelling and tenderness at the injection site;
- Irritation of structural and functional elements (parenchyma) of the liver.
Overdose may develop allergic reactions and dysuric disorders, irritation and burning of the urethra and urinary tract, hematuria.
Hexamethylenetetramine is one of the components of the Teymurov paste - an external antiseptic and disinfectant.
Do not use the solution and tablets after the expiration date indicated on the package.
The effectiveness of therapy with the use of Hexamethylenetetramine is reduced when it is simultaneously administered with drugs that are characterized by the ability to alkalize urine, in particular with:
- Thiazide diuretics;
- Antacid medications;
- Sodium bicarbonate;
- Carboanhydrase inhibitors.
Synonyms (analogs for the active substance) Hexamethylenetetramine are Aminoform, Hexamine, Methenamine, Metramine, Urizol, Urotropin, Cystogen, Cystamine and Formamin.
The group of analogues of the drug mechanism of action include: 5-NOC Galenofillipt, dioxins, Dioksidin, zyvox, Kirin, Kubitsin, Monural, Nitroxoline, ristomycin sulfate Sanguirythrine, Urofosfabol, fosfomycin, Eucalyptus tincture, Linezolid-Teva, Zeniks, Amizolid.
Terms and conditions of storage
From pharmacies Hexamethylenetetramine dispensed in non-prescription mode. Store the tool, according to the manufacturer's recommendations, should be in a dark place at temperatures up to 20 ºС. If these conditions are met, the term of the drug is 5 years.