Gastrozol is a drug intended for the treatment of diseases associated with impaired acidity.
Release form and composition
The drug is produced in the form of solid opaque gelatin capsules of size No. 2, which are filled with white pellets inside. The body of the capsules is light pink in color, the cap is pinkish-brown. Gastrosol is produced in blisters of 7 or 10 pcs. and in polymer cans of 10, 14 and 28 pcs.
Each capsule contains 20 mg of omeprazole and excipients - sucrose, lactose, hypromellose, talc, sodium hydrogen phosphate and hydroxide, calcium carbonate, mannitol, diethyl phthalate, cetyl alcohol, polysorbate-80, sodium lauryl sulfate, ethylacrylate copolymer, citric acid, sodium nitrate, glycolite, 80%, sodium lauryl sulfate, ethylacrylate copolymer, methylacrylate, polysorbate-80, sodium lauryl sulfate, ethyl acrylate and methacrylate; , propylene glycol and copolymer.
The caps and body of Gastrozol capsules include propyl parahydroxybenzoate, gelatin, titanium dioxide, methyl parahydroxybenzoate and iron oxide red.
Indications for use
Gastrozole, according to the instructions, is used for the prevention of recurrence and treatment of gastric ulcer and 12 duodenal ulcer, and is also prescribed in complex therapy with antibiotics for the eradication of Helicobacter pylori in patients with duodenal ulcer and stomach.
The drug is used in the treatment of NSAIDs, gastropathy, reflux esophagitis and hypersecretory conditions - systemic mastocytosis, polyendocrine adenomatosis, Zollinger-Ellison syndrome and stress ulcers of the gastrointestinal tract.
The use of Gastrozole is contraindicated in the case of pregnancy, during the breastfeeding period, as well as in case of hypersensitivity to the components that make up the drug. The drug is not prescribed to children under 18 years of age.
With caution, Gastrozole is prescribed to patients with renal and hepatic insufficiency.
Dosing and Administration
Gastrozol capsules are taken orally in the morning before or during breakfast, squeezed water. The dosage of the drug depends on the disease, namely:
- In cases of erosive and ulcerative lesions of the gastrointestinal tract associated with the intake of NSAIDs, 1 capsule per day is prescribed for 4-8 weeks;
- In order to eradicate Helicobacter pylori, patients take 1 capsule of Gastrozole twice a day for 7 days (in combination with anti-bacterial drugs);
- Patients with erosive-ulcerative esophagitis and gastric ulcer in the acute phase are prescribed 1-2 capsules per day for 4-8 weeks;
- In case of peptic ulcer of 12 duodenal ulcer patients take 1 capsule per day for 2-4 weeks, with a possible increase in the dose, if necessary, twice;
- For the prevention of recurrence of duodenal ulcer and stomach, as well as reflux esophagitis, patients are prescribed 1 capsule per day.
Patients with Zollinger-Ellison syndrome determine the dose of gastrozole by a doctor individually. In most cases, the initial dose is 60 mg per day, then it can be increased to 40-60 mg taken twice a day.
In accordance with the instructions, gastrosol may cause peripheral edema, visual impairment, gynecomastia, malaise and side effects from various body systems, namely:
- Myalgia, arthralgia and myasthenia (bone and muscular system);
- Increased liver transaminases, nausea, vomiting, diarrhea, abdominal pain, stomatitis, impaired liver function, hepatitis, dry mouth, the formation of gastric glandular cysts, impaired taste and flatulence (digestive system);
- Thrombocytopenia, leukopenia, pancytopenia and agranulocytosis (hematopoietic system);
- Excitement, headache, dizziness, encephalopathy and depression (peripheral and central nervous system).
Gastrozole also causes the following adverse reactions:
- Angioedema, urticaria, interstitial nephritis, fever, anaphylactic shock and bronchospasm (allergic reactions);
- Alopecia, photosensitization, erythema multiforme exudative, skin rash and itching (dermatological reactions).
In cases of overdose of gastrosol, blurred vision, arrhythmia, headache, drowsiness, confusion, dry mouth, nausea and tachycardia occur. Patients in such cases prescribe symptomatic treatment.
Before using Gastrozole, it is important to exclude the presence of a malignant process, especially in patients with gastric ulcer. Such precautions are due to the fact that the drug can mask the symptoms and make it difficult to make a correct diagnosis.
Due to the fact that the active ingredient of the drug (omeprazole) increases the pH of the stomach, Gastrozole reduces the absorption of iron salts, ampicillin esters, ketoconazole and itraconazole. It should also be borne in mind that omeprazole may increase plasma concentration and reduce the excretion of phenytoin, diazepam and indirect anticoagulants, therefore in some cases it is necessary to reduce the dose of these drugs.
The drug enhances the inhibitory effect of other drugs on the hematopoietic system.
Medicines Zhelkizol, Romesek, Ulkozol, Tsisagast, Helicid, Omipix, Sopral, Losek, Promez and Zerocid are considered to be synonymous with the drug.
Analogues of Gastrozol are medicines Zipantola, Epicurus, Ulter Lanzabel, Controlok, Pariet, Sanpraz, Ontime, Nexium and Helicol.
Terms and conditions of storage
The instructions to Gastrozol indicate that the drug must be stored in a well-ventilated, dry, dark place and out of reach of children, at room temperature.
From pharmacies, the drug is released on prescription. The shelf life of capsules, subject to compliance with all the recommendations of the manufacturer, is three years. After the expiration date Gastrozol must be disposed of.