Garazon is a combination drug for topical use, which has anti-allergic, anti-inflammatory and bactericidal activity.
Release form and composition
Garazon comes in the form of a sterile aqueous solution for instillation into the eyes and ears.
Active ingredients Garazona:
- Gentamicin - 3 mg / ml;
- Betamethasone sodium phosphate - 1 mg / ml.
As auxiliary substances, benzalkonium chloride, sodium bisphosphate, sodium citrate, sodium chloride, sodium bromide, sodium phosphate, disodium dithate are used.
In the sale of the tool comes in dropper bottles of 5 ml of polyethylene.
Indications for use
According to the instructions to Garazon, indications for the use of the drug are:
- Injuries caused by a foreign body in the eye, thermal or chemical burns, exposure to radiation;
- Postoperative eye injuries;
- Secondarily infected conjunctivitis (keratoconjunctivitis);
- Staphylococcal blepharoconjunctivitis (regional blepharitis);
- Dacryocystitis (inflammation of the lacrimal sac, located between the inner corner of the eyelids and the nose);
- Meibomit (barley);
- Acute or chronic otitis externa;
- Eczema of the external auditory canal.
The use of Garazona is contraindicated in:
- Inflammation of the cornea due to herpesvirus activity (herpetic keratitis);
- Lesions of the outer and cornea of the eye in case of viral infections (including chickenpox);
- Mycosis of the eye (damage to the organs of vision fungal infection);
- Mycobacterial lesions of the eyes and ears;
- Tuberculosis of the ears and eyes;
- Otomycosis (ear lesions fungal infection);
- Perforation or absence of the eardrum;
- Conditions characterized by thinning of the sclera and cornea of the eye (including in conditions that result from surgical removal of a foreign body from the anterior part of the eye);
- Hypersensitivity to the drug;
According to the instructions for Garazon, in pediatrics, the drug is not used to treat children under 6 years of age.
Dosing and Administration
In case of ophthalmologic diseases, the optimal dosage regimen is selected individually for each patient.
The instructions for the drug indicate that the standard treatment regimen involves the introduction into the conjunctival sac 1-2 drops of the solution 3 or 4 times a day.
In the acute course of the disease, the frequency of use of Garazona is allowed to increase: the solution is injected into the affected eye with 2 drops every hour or two. When the disease becomes controlled, the number of instillation should be reduced.
The duration of use of Garazona is determined by the severity of the disease and the characteristics of the clinical situation. In the absence of the desired effect within 14 days, further treatment with the use of this drug is considered inappropriate.
In case of ear diseases, before making instillation, the ear canal should be thoroughly cleaned. Starting single dose of the drug - 3-4 drops. The multiplicity of procedures - from 2 to 4 per day.
At the time of the introduction of Garazona patient should lie on his side, with a sore ear up. After instillation of the drug to ensure better penetration of the solution into the ear canal in this position it is necessary to remain for several minutes.
When reducing the severity of symptoms of inflammation, the dosage is gradually reduced. Completely stop the treatment after the disappearance of all signs of the disease.
An alternative method of treatment of ear diseases is the introduction into the external auditory canal of a cotton swab soaked in Garazon solution. The tampon should remain wet all the time, for which it is recommended to moisten it every four hours. Swab replacement is performed once a day.
If Garazon is used to treat chronic forms of eye and ear diseases, treatment should be stopped gradually, by reducing the number of uses.
According to the annotation to the drug, most often Garazon causes a brief burning sensation, increased dryness and itching at the site of application.
The undesirable effects that accompany the use of glucocorticosteroids (which include betamethasone sodium phosphate) in the treatment of eye diseases include:
- Hypertension of the eye;
- Decreased visual acuity;
- Defeat of the optic nerve;
- The narrowing of the visual fields;
- Rear subcapsular cataract;
- Slowing wound healing;
- Secondary infection of the eye (for example, herpes zoster virus);
- Penetration of air bubbles after cataract surgery;
- Acute iridocyclitis;
- Perforation of the cornea and sclera;
- Accommodation disturbance;
The antibiotic, gentamicin, which is part of the drug, can cause allergic reactions and transient eye irritation.
Prolonged use of high doses of glucocorticosteroids can provoke suppression of the function of the hypothalamus-pituitary-adrenal system and Itsenko-Cushing's disease (hypercorticism). A systematic excess of a therapeutic dose of aminoglycoside antibiotics causes an ototoxic effect, which is manifested by the development of neuritis of the auditory nerve.
If overdose symptoms appear, a gradual withdrawal of Garazona is recommended. If necessary, symptomatic therapy is carried out.
The structural analogue of Garazona is Betagenot.
According to the mechanism of action, the following drugs Maxitrol, Dexon, Sofradex, Tobradex, Trabon, DexTobropt can be considered analogues of Garazona.
Terms and conditions of storage
From pharmacies Garazon dispensed by prescription. Store the drug should be at a temperature not exceeding 25 ºC in a dark, out of reach of children. The shelf life of the drops is 3 years.