Diuver - a drug used in the treatment of diseases of the cardiovascular system.
Release form and composition
Diuver is produced in the form of round white biconvex tablets, on one side of which there is a risk and engraving "915", and on the other facet, in blisters of 10 pieces.
The composition of one tablet includes 5 mg of torasemide and such excipients as:
- 58.44 mg lactose monohydrate;
- 0.6 mg of magnesium stearate and silicon dioxide anhydrous colloid;
- 14.56 mg of corn starch;
- 0.8 mg sodium carboxymethyl starch.
They also produce biconvex white round pills Diuver, with a risk and engraving "916" on one and a facet on the other side, 10 pieces each. in blisters.
One tablet contains 10 mg of torasemide and excipients - 1.2 mg of silicon dioxide of colloidal anhydrous and magnesium stearate, 116.88 mg of lactose monohydrate, 1.6 mg of sodium carboxymethyl starch and 29.12 mg of corn starch.
Indications for use
The instructions to Diuver indicated that the drug is prescribed in cases of arterial hypertension and edema syndrome.
The use of Diuvera is contraindicated in children under 18 years of age, in case of hypersensitivity to the active and auxiliary components of the product, as well as in the following cases:
- Hepatic coma and precoma;
- Pronounced violations of urine outflow of any etiology;
- Hypovolemia or dehydration;
- Decompensated aortic and mitral stenosis;
- Acute glomerulonephritis;
- Hypertrophic obstructive cardiomyopathy;
- Severe hypokalemia and hyponatremia;
- Renal failure with anuria;
- Lactose intolerance, glucose-galactose malabsorption and lactase deficiency;
- During the period of breastfeeding;
- Increases in central venous pressure;
- Intoxication with cardiac glycosides.
With caution, Diuver is prescribed during pregnancy, patients with hypoproteinemia, arterial hypotension, abstinence therapy, and stenosis of atherosclerosis of cerebral arteries, hepatorenal syndrome, anemia, susceptibility to hyperuricemia, diabetes, ventricular arrhythmia, gout syndrome, susceptibility to hyperuricemia, diabetes, ventricular arrhythmia, gout syndrome, susceptibility to hyperuricemia, diabetes, ventricular arrhythmia, gout syndrome, susceptibility to hyperuricemia, diabetes, ventricular arrhythmia, gout syndrome, susceptibility to hyperuricemia, diabetes, ventricular arrhythmias, susceptibility to hyperuricemia, diabetes, ventricular arrhythmias, susceptibility to hyperuricemia, diabetes, ventricular arrhythmias, susceptibility to hyperuricemia, diabetes, ventricular arrhythmias, susceptibility to hyperuricemia;
Dosing and Administration
Tablets are taken orally in the morning after eating, drinking water. Dosage means 1 tablet (5 mg) once a day.
In cases of edema syndrome of various origins, patients with chronic heart failure, kidney, liver or lung diseases are prescribed 5 mg of Diuvera a day, followed by a gradual increase in dose to 20-40 mg per day. Therapy means to continue until the complete disappearance of edema.
The initial dose of the drug for arterial hypertension is half the tablet (2.5 mg) once a day, with a possible increase in the dose to 5 mg.
The instructions to Diuver indicated that the drug may cause side effects from some body systems, namely:
- Hyponatremia, hypomagnesemia, metabolic alkalosis, hypochloremia, hypocalcemia and hypokalemia (water-electrolyte and acid-base balance);
- Excessive reduction in blood pressure, tachycardia, arrhythmia, orthostatic hypotension, decrease in circulating blood volume and collapse (cardiovascular system);
- Hypercholesterolemia, hypertriglyceridemia, a transient increase in the concentration of urea and creatinine in the blood (metabolism);
- Oliguria, decreased potency, acute urinary retention, hematuria, and interstitial nephritis (urinary system);
- Nausea, diarrhea, vomiting, acute pancreatitis, intrahepatic cholestasis and increased activity of liver enzymes (digestive system);
- Hearing impairment, tinnitus and paresthesia (nervous system).
Diuver can also cause side effects from the skin and peripheral blood, namely:
- Pruritus, urticaria, erythema multiforme, exfoliative dermatitis, purpura, fever, vasculitis, eosinophilia, and photosensitization;
- Thrombocytopenia, leukopenia, agranulocytosis, aplastic or hemolytic anemia.
Symptoms of an overdose of Diuvera are an excessive increase in diuresis, accompanied by a decrease in the volume of circulating blood and an electrolyte imbalance of the blood, gastrointestinal disorders, drowsiness, lower blood pressure, collapse and confusion.
In such cases, it is necessary to cancel the drug or reduce its dose, to carry out gastric lavage, to appoint activated charcoal and symptomatic therapy.
Patients with long-term use of Diuvera in high doses should follow a diet with a sufficient amount of salt in food and take potassium preparations in order to avoid the development of such conditions as:
- Metabolic alkalosis;
It should be borne in mind that during therapy with Diuver patients with renal insufficiency may develop disorders of water and electrolyte balance. In this regard, it is recommended that patients in this group periodically monitor the concentration of electrolytes in the blood plasma, creatinine, the acid-base state, uric acid and residual nitrogen, and, if necessary, carry out appropriate corrective therapy.
Patients in the period of use of Diuvera should refrain from conducting potentially hazardous activities that require increased attention and speed of psychomotor reactions.
Synonyms of the drug are Torasemide Canon, Britomar and Trigrim. The analogs of Diuvera include Furosemide Sopharma, Lasix and Bufenox.
Terms and conditions of storage
In accordance with the instructions, Diuver must be stored in a well-ventilated, protected from light, dry and out of reach of children, at a temperature not exceeding 30 ºС.
From pharmacies, the drug is released on prescription. The shelf life of tablets, subject to the basic recommendations of the manufacturer, is three years.