Distreptase

Distreptaza is an enzyme preparation used to treat inflammatory diseases of the pelvic organs, warning of complications after surgical interventions in the abdominal cavity and in the pelvis. Also, the drug is effective in the formation of fistulas and paraproctitis, urethroprostatitis of various etiologies, exacerbation of hemorrhoids.

Release form and composition

Distreptase release candles rectal white-cream color of a cylindrical shape. 1 suppository contains 15000 IU of streptokinase and 1250 IU of streptodornase. Auxiliary components of the drug are vitepsol H15 and paraffin oil.

Indications for use

According to the instructions Distreptaza is indicated for use in the following cases:

• Endometritis (inflammatory processes in the inner mucous membrane of the uterus);
• Chronic and acute adnexitis (inflammation of the uterus);
• Infiltration diseases of the pelvic organs (in the period after the operation or in the accumulation of unusual substances in the tissues;
• Salpingitis;
• Chronic or acute inflammation of hemorrhoidal veins;
• Follicular cysts (enlarged follicle).

Distreptaza prescribed to reduce swelling with:

• Pararectal abscesses (inflammatory processes in adrectal tissue);
• Purulent caudal cysts (located in the lower part of the spine);
• Pararectal fistula, which is a pathological channel between the surface of the body or the cavity and the focus of inflammation.

According to numerous reviews, distreptase can be used effectively after surgery on the pelvic organs and the abdominal cavity in order to prevent the formation of adhesions or resorption of existing ones.

Contraindications

According to the instructions, Distreptase should not be used in the presence of fresh stitches and wounds in the anorectal region, as this may cause the stitches to relax and lead to bleeding from the wound.

Suppositories are also contraindicated for women during pregnancy and lactation. Do not use the drug in the presence of bleeding or tendency to them.

With care Distreptaza is used in case of hypersensitivity to one or both active components contained in suppositories.

Dosing and Administration

Distreptase rectal candles are inserted deep into the anus. The dosage of the drug is prescribed individually by the attending physician, depending on the severity of the disease and the effectiveness of therapy.

In severe inflammatory process, the standard dose of Distreptase is 1 candle three times a day for three days, then three more days are used 1 candle two times a day. At the final stage of treatment, the dosage is 1 candle once a day for three days.

For mild inflammatory processes or moderate severity, suppositories are administered in 1 unit twice a day in the first three days, in the next four or two days - in 1 candle once or twice a day, respectively. As a rule, the duration of therapy is 1-1.5 weeks. During the course of treatment is used 8-18 suppositories.

Side effects

The use of Distreptase in most cases is well tolerated by patients, side effects are rarely developed. The most common side effects are:

• Dizziness;
• Allergic reactions;
• Inhibition of the anticoagulant blood system;
• Increased body temperature.

Patients should be advised that Distreptase may increase the likelihood of bleeding.

No cases of distreptase overdose have been reported to date.

special instructions

The drug is not prescribed in pediatric practice due to the lack of clinical experience with children.

The use of Distreptase does not affect the ability to control potentially dangerous mechanisms that require increased concentration of attention.

Analogs

Structural analogues of distreptase and drugs that have similar pharmacological effects are:

• Batroxobin injection;
• Biobrepping

Terms and conditions of storage

According to the instructions Distreptaza suppositories rectal should be stored in a cool place (preferably in the refrigerator). If storage conditions are met, the shelf life of the drug is 2 years.