Dysport is a muscle relaxant of peripheral action.
Release form and composition
Dysport is available in the form of a lyophilisate for preparing a solution for injection. As an active component, it includes the botulinum toxin type A complex - hemagglutinin, its concentration in one vial - 300 or 500 U.
Excipients: human albumin and lactose.
Indications for use
The use of Dysport is indicated for the treatment of:
- Hemifacial spasm (Brisso's disease);
- Spasticity of the arm after a stroke;
- Hyperkinetic facial folds (facial wrinkles) in adults;
- Hyperhidrosis (hyperhidrosis) in the armpits.
According to the instructions for Dysport, the drug can be used in pediatrics for the treatment of dynamic foot deformation associated with cerebral palsy in children over two years of age.
The use of Dysport is contraindicated in case of hypersensitivity to its components, as well as pregnant and breastfeeding women.
In case of acute diseases, it is allowed to administer the drug only after recovery.
Dosing and Administration
Adults (including the elderly), treatment of bilateral blepharospasm is recommended to start with a dose of 120 IU per eye. Dysport solution is injected under the skin:
- Medially - in a volume corresponding to 20 U (or 0.1 ml);
- Laterally into the joint between the orbital and preceptal parts of the upper and lower orbital muscles of the eye - in a volume corresponding to 40 U (or 0.2 ml).
When performing injections of Dysport in the upper eyelid (in order not to touch the muscle that raises it), the needle should be directed away from the center.
The first clinical effect appears after 2-4 days, the maximum - develops within 14 days. To prevent recurrences, repeat injections, maintaining between them 12-week intervals and reducing the dose with each subsequent injection of the solution. The dosage is adjusted for therapeutic effect.
If blepharospasm is unilateral, injections are limited to the area of the affected eye. Patients with hemifacial spasm are treated according to a similar regimen.
With crooked adults with well-developed cervical muscles and normal body weight, Dysport is administered in portions into two or three of the most active cervical muscles. Total single dose - 500 U.
If rotational torticollis is prescribed, 350 PIECES of the drug are administered to the belt muscle of the head, ipsilateral to the direction of rotation of the head, and another 150 PIECES to the contralateral rotation of the sternocleidomastoid muscle.
With laterocollis, treatment involves the introduction of 150 IU of ipsilateral into the sternocleidomastoid muscle and 350 IU of the drug into the belt muscle of the head, homolaterally to the direction of rotation of the head.
If Dysport is administered in three muscles, the dose is distributed as follows:
- 300 U - in the belt muscle;
- 100 U - in the sternocleidomastoid muscle;
- 100 U - in a different muscle.
With the anterior knee curvature, Dysport is prescribed in a dose of 150 IU in two sternocleidomastoid muscles, and in the posterior one, 250 IU in each belt muscle of the head. At the subsequent appointment, dose adjustment is carried out taking into account clinical efficacy. The maximum allowable dosage is 1000 U.
For facial wrinkles, Dysport is prescribed in a total dose of 200 IU, injected into the back of the nose, forehead, outer corner of the eye and between the eyebrows.
After 3 months after a stroke, the drug is administered in a dose of 1000 IU, distributing between the five muscles - the biceps of the shoulder, the deep and superficial flexor of the fingers, and the radial and elbow flexor of the wrist.
In case of hyperhidrosis, 100-200 U is prescribed for each axillary region.
The most common side effects of Dysport are skin rashes, a short-term burning sensation at the injection site (usually within 1-2 minutes), flu-like symptoms.
Treatment of Brisso's disease and blepharospasm is often accompanied by blepharoptosis. In some cases, possible diplopia and the spread of paralytic effects on the medial facial muscles (as a rule, these phenomena are transient in nature and disappear within 14-30 days after discontinuation of treatment). Sometimes dry eye mucosa, keratitis, puffiness and hematomas of the eyelids, transient external ophthalmoplegia are noted.
Often dysphagia occurs when using Dysport. It develops mainly in patients by whom the solution is injected into the sternocleidomastoid muscle, and is dose-dependent. Less common may be: weakness of the neck muscles, change in voice, increased dry mouth, general weakness, difficulty breathing, impaired vision. These side effects disappear in 2-4 weeks.
With spasticity of the hands in stroke patients, the following are possible: muscle weakness, fatigue, soreness at the site of the introduction of Dysport, general weakness, drowsiness. Side effects disappear within 14 days.
In children with cerebral palsy, according to the instructions for Dysport, treatment may develop: local skeletal muscle weakness (and therefore falls are sometimes possible), drowsiness, pain at the injection site, asthenia, fatigue, nausea, flu-like syndrome. These symptoms usually disappear within 14 days.
Patients who undergo a course of correction of mimic wrinkles may notice side effects such as: reversible ptosis (omission) of the upper eyelid, soreness, hematomas, and numbness at the injection site, headache, ptosis / eyebrows. Diplopia is extremely rare.
When using Dysport, it should be remembered that its units of action are specific, so it is incorrect to compare them with those for other drugs that include botulinum toxin.
RELATOX Toxin, Botox, Xeomin, Lantox.
Terms and conditions of storage
Dysport does not go on sale through the pharmacy chain. It is released and applied only in specialized medical institutions.
Bottles are stored at a temperature of 2-8 ºС. Shelf life - 2 years.