Diprivan is a means for intravenous general anesthesia.
Release form and composition
Diprivan is available in the form of an emulsion for intravenous administration.
The active component of the drug - propofol, in 1 ml of its emulsion contains 10 mg.
As auxiliary substances, soy bean oil, glycerol, egg yolk phospholipids, Trilon B (in anhydrous equivalent), sodium hydroxide (in an amount sufficient to maintain a pH of 7.5-8.5), water for injections are used.
Diprivan is sold in 20 ml glass ampoules and 50 ml glass syringes.
Indications for use
According to the instructions to Diprivan, the drug is used:
- For induction anesthesia and maintenance of general anesthesia;
- For sedation (introduction to medication sleep) of patients who are on a ventilator (mechanical ventilation) during intensive therapy;
- To ensure a sedative effect in the consciousness of patients during diagnostic procedures or surgical interventions.
Diprivan is not prescribed:
- Newborn babies (in the first 4 weeks of life);
- Children and adolescents up to 16 years of age who are on a ventilator with intensive care;
- Conscious children and adolescents under 16 years of age during diagnostic procedures or surgical interventions;
- In obstetric practice (an exception is the case of abortion in its first trimester);
- With lactation;
- When hypersensitivity to the drug.
Like all other means for intravenous anesthesia, Diprivan is recommended to be administered with caution to overly debilitated patients, as well as to patients with:
- Diseases of the heart and blood vessels;
- Impaired renal and / or liver function;
- Impaired lipid metabolism;
- Respiratory diseases;
Dosing and Administration
Emulsion Diprivan is intended for intravenous administration.
Regardless of whether or not premedication, in satisfactory condition, adult patients with normal body weight, general anesthesia is induced with Diprivan using a titration method until clinical signs of anesthesia appear, taking into account the patient's response to anesthesia. The drug is administered with a bolus or infusion of approximately 0.04 grams every 10 seconds.
As a rule, for an adult under the age of 55, the dose of Diprivan is on average from 1.5 to 2.5 mg / kg. Reducing the total dose produced by reducing the rate of administration to 0.02-0.05 grams per minute. Older patients usually require a lower dose.
Patients belonging to the 3rd and 4th grades on the ASA scale (that is, patients with severe and extremely severe disorders of the general condition, which can significantly impair physiological functions, cause damage to vital functions or threaten life), receive Diprivan emulsion with an even lower speed: 20 mg every 10 seconds.
For babies up to 3 years, the drug is administered slowly until signs of anesthesia appear. The dose is selected and adjusted depending on the age and body weight of the patient. As a rule, the average dose for children over the age of 8 is 2.5 mg / kg; children up to the age of 8 may need a higher dosage. At a lower dose, according to the instructions, Diprivan should be administered to children whose condition on the ASA scale is assessed as severe or very severe (Grade 3 and 4).
In accordance with the instructions to Diprivan, the effect after the introduction of the means develops in about 30 seconds.
In most cases, induction of anesthesia using Diprivan proceeds smoothly, with minimal signs of arousal. The most frequent side effects are predictable from the point of view of pharmacology. They are expressed in the form of temporary apnea and hypotension. Some cases of these or other adverse reactions are often due to ongoing procedures or the patient's condition.
Induction of anesthesia can cause:
- Pain at the injection site;
- Withdrawal and flushing syndrome (in children);
- Nausea, vomiting, and headaches on waking;
- Temporary sleep apnea during induction of anesthesia;
- Epileptiform seizure (including opisthotonus and convulsions during induction and maintenance of anesthesia, as well as upon awakening);
- Postoperative fever;
- Urine discoloration (as a rule, this is observed with prolonged administration of Diprivan);
- Sexual disinhibition;
- Edema of the lungs;
- Postoperative unconsciousness.
Accidental overdose of Diprivan is accompanied by inhibition of the functions of the cardiovascular and respiratory systems. Treatment involves the use of mechanical ventilation with oxygen, as well as the introduction of pressor and plasma-substituting agents.
If general anesthesia is used as an adjunct to regional anesthesia methods, Diprivan is recommended to be given at a lower dose.
Pharmacological incompatibility with the means for spinal and epidural anesthesia, with muscle relaxants, analgesics, drugs for sedation and inhalation anesthesia was not observed.
Before using Diprivan, it is contraindicated to mix the emulsion with any other solutions for infusion or injection. The exceptions are a five percent solution of dextrose in glass vials or PVC bags, alfentanil for injection in plastic syringes and lidocaine.
If necessary, the introduction of muscle relaxants mivakurium and atrakurium is unacceptable without prior flushing to use the same infusion line as for Diprivan.
Synonyms: Pofol, Propovan, Propofol, Rekofol, Provayv.
Terms and conditions of storage
Diprivan is a prescription drug.
Keep it out of the reach of children at a temperature not exceeding 25 ° C. Shelf life - 3 years.