Difluzol is an antimicrobial drug intended for systemic use.
Release form and composition
Diffusol is produced in the form of gelatin solid capsules, with a green lid and a turquoise body, in blisters of 1 pc. Inside the capsule is filled with white powder.
The composition of one capsule includes 50, 100 or 150 mg of fluconazole and excipients - calcium stearate and sodium carboxymethyl starch.
The capsule body consists of gelatin, a blue patent, titanium dioxide, and a quinoline yellow dye. The cap includes titanium dioxide, azorubine and gelatin.
Indications for use
The instructions to Difluzol indicated that 50 and 100 mg capsules are prescribed for the treatment of candidiasis of the mucous membranes, cryptococcosis, systemic candidiasis, pityriasis, and deep endemic mycoses. It is also used for the prevention of fungal infections in patients with malignant tumors during radiation therapy and treatment with cytostatic agents.
150 mg capsules Diflucisol is used for onychomycosis, genital candidiasis and mycoses of the skin.
The use of Difluzole is contraindicated in children under 18 years of age, in case of hypersensitivity to the active and auxiliary components of the product, as well as in the following cases:
- Pregnancy and during the breastfeeding period;
- Simultaneous intake of astemizole, cisapride or terfenadine.
With caution Diflyuzol prescribed to patients with AIDS and severe impaired renal function and liver.
Dosing and Administration
Capsules are taken orally with a small amount of water. The dosage of Difluzol is determined individually and directly depends on the severity and nature of the fungal infection, namely:
- In cases of vaginal candidiasis, 150 mg is prescribed per day;
- In case of mycoses of the skin, 150 mg of the drug is prescribed once every 7 days, or 50 mg once a day for 2-6 weeks;
- Patients with candidiasis of the mucous membranes take 50-100 mg of Difluse once a day for 14-30 days;
- In cases of cryptococcal infections, patients take 400 mg of the drug on the first day, then reduce the dose to 200-400 mg once a day;
- The recommended dose of Difluse for onychomycosis is 150 mg 1 time in 7 days. Therapy should be continued until the affected nail is completely replaced with a healthy one;
- In the prevention of fungal infections in patients with reduced immunity, the dose of the drug is 50 mg 1 time per day.
The dosage of the drug for deep endemic mycoses is 200-400 mg per day. The duration of treatment is determined individually and varies from 1 to 24 months.
The instructions to Difluzol indicated that the drug may cause side effects from some body systems, namely:
- Headache, insomnia, vertigo, dizziness, tremor, drowsiness, convulsions, paresthesia and taste disturbance (nervous system);
- Abdominal pain, indigestion, diarrhea, dry mouth, flatulence, nausea, dyspepsia and vomiting (digestive system);
- Leukopenia, thrombocytopenia and agranulocytosis (blood and lymphatic system);
- Angioedema, urticaria, skin itching and swelling of the face (immune system);
- Hypercholesterolemia, hypokalemia and hypertriglyceridemia (metabolism);
- Toxic liver damage, increased levels of liver enzymes and bilirubin, hepatitis, liver failure, cholestasis, hepatocellular damage and jaundice (hepatobiliary system);
- Alopecia, hyperhidrosis, acute generalized exantmatous pustules, exfoliative dermatitis and rash (skin and subcutaneous tissue).
Difluse can cause fever, weakness, myalgia and asthenia, as well as cardiovascular side effects, namely:
- Paroxysmal ventricular tachycardia type "pirouette";
- Lengthening the QT interval.
Symptoms of a drug overdose are paranoid behavior and hallucinations. In such cases, gastric lavage and forced diuresis are required.
In cases of simultaneous use of Difluzole with coumarin anticoagulants, it is recommended to monitor the prothrombin index.
Due to the fact that premature drug withdrawal leads to relapse, drug therapy should be continued until the onset of clinical and hematological remission.
If, during therapy with a drug, the activity of liver enzymes increases, the feasibility of further treatment with the drug should be determined.
With the use of Diflucola, toxic epidermal necrolysis and Stevens-Johnson syndrome may develop.
It should be noted that the drug enhances the action of oral hypoglycemic agents, anticoagulants, hydrochlorothiazide and difenina, as well as:
- Increases the effectiveness of phenytoin and rifabutin;
- With simultaneous use with zidovudine and cyclosporine - increases their concentration in the blood;
- Increases midazolam concentration.
The synonyms of the drug are Mikomax, Vero-Fluconazole, Fluunol, Disorel Sanovel, Procanazole, Nofung, Diflucan, Fluconazole, and Ciscan.
Diflucisol analogs include Mikonikhol, Kanditral, Vfend, Biflurin, Itraconazole-ratiofarm, Rumikoz, Orungal, Noxafil, Vikand and Technasol.
Terms and conditions of storage
In accordance with the instructions, Difluzol should be stored in a well-ventilated, protected from light, dry and out of reach of children, at a temperature not exceeding 25 ºС.
From pharmacies, the drug is released on prescription. The shelf life of capsules, subject to the basic recommendations of the manufacturer, is four years.