Diazolin is an antihistamine drug that belongs to the group of H1-histamine receptor blockers, which has antiallergic and antipruritic, as well as m-holinoblokiruyuschee and weak sedative effect.
Release form and composition
Diazolin dosage forms - tablets and dragees intended for oral administration.
The active ingredient of the drug is mebgidrolina nazizilat. Its concentration in one tablet and one tablet can be 50 or 100 mg.
Indications for use
According to the instructions for diazolin, the drug is used to treat:
- Allergic conjunctivitis;
- Hay fever;
- Allergic rhinitis;
- Drug allergies;
- Contact and atopic dermatitis, accompanied by severe itching;
- Skin reactions to insect bites (including wasps, bees, bumblebees).
As part of complex therapy, diazolin is sometimes used for bronchial asthma.
The use of diazolin is contraindicated in:
- Angle-closure glaucoma;
- Prostatic hypertrophy;
- Peptic ulcer;
- Duodenal ulcer;
- Inflammation of the intestinal walls;
- Propensity to convulsive syndrome;
- Exacerbation of inflammatory diseases of the digestive tract;
- Heart rhythm disorders;
- Pyloric stenosis;
- Astenodepressive syndrome;
- Atonia of the intestine or bladder;
- Hypersensitivity to mebhydroline nasisizilate;
- Glucose-lactose intolerance.
Diazolin may be used, but with extreme caution and under constant medical supervision for patients with kidney and / or liver disease.
Dosing and Administration
According to the instructions to Diazolin, it is recommended to take tablets / pills during or after meals, without chewing and drinking plenty of non-carbonated water.
Depending on the severity of the course of the disease, the daily dose may be:
- For adults and children over 10 years old - from 100 to 300 mg (100 mg 1-3 times a day);
- For children 5-10 years old - 100-200 mg (50 mg 2-4 times a day);
- For children 2-5 years old - from 50 to 150 mg (50 mg 2 or 3 times a day);
- For babies up to 2 years old - 50-100 mg (50 mg 1 or 2 times a day).
The maximum allowable daily dose for adults: single - 300 mg daily - 600 mg.
The duration of diazolin use is determined by the nature of the disease and the effectiveness of the therapy. As a rule, it is 3-7 days. If necessary, longer treatment is prescribed another drug.
The use of diazolin may be accompanied by the following undesirable reactions:
- From the nervous system and sensory organs: increased fatigue, paresthesias, dizziness, when using high doses - slowing down the reaction rate, blurred vision, drowsiness, in children - irritability, sleep disturbance, increased excitability, tremor;
- On the part of the digestive system: dry mouth, nausea, heartburn, pain in the epigastric region, irritation of the gastric mucosa, dyspeptic disorders, constipation, vomiting;
- From the side of blood-forming organs: agranulocytosis, granulocytopenia;
- On the part of the urinary system: impaired urination.
Patients with kidney and / or liver diseases may have a toxic effect of Diazolin, which is manifested by increased severity of side effects. In this case, the dosage and / or frequency of doses should be reduced, in severe cases, it may be necessary to cancel the drug.
Overdose symptoms: drowsiness, confusion, depression of CNS function, anticholinergic effects (dilated pupils, nausea, vomiting, dryness of the oral mucosa, epigastric pain).
And although Diazolin is well tolerated, with long-term use it increases the likelihood of side effects. For this reason, the drug is practically not used in the treatment of chronic allergic diseases. Its main purpose is to relieve the symptoms of acute allergic reactions at their earliest stages.
Unlike the first generation of antihistamines, mebhydrolin slightly penetrates the central nervous system, and therefore does not have a sedative or sedative effect.
Relatively frequent side effects of diazolin with potentially serious consequences are dizziness, blurred vision and drowsiness, therefore during the period of treatment with this drug it is recommended to refrain from driving and performing activities that require mental and / or physical speed, visual acuity, concentration.
During the period of treatment with diazolin, you should not drink alcoholic beverages, take sedatives and drugs that suppress the central nervous system, because mebhydrolin enhances their effect.
Structural analogues of Diazolin (on the active substance) are Dialin, Mebgidron and Omeril.
The following drugs belong to the same pharmacological group (“Antihistamines of systemic action”) and are characterized by a similar mechanism of action: Aviamarin, Alerpriv, Allerfex, Histafen, Gifast, Desal, Desloratadine, Diazin, Dimebon, Dimedrokhin, Dinox, Dramina, Kestin, Kestin, Detsen, Dimebon, Dimebon, Dimedrokhin, Dinox, Dramina, Kestin, Kestin, Kin, Datsin. Klalergin, Clargotil, Claridol, Claritens, Clariten, Clarothin, Lomilan, Lorenin, Lorodin, Lorodin, Lorodin, Lorodin, Lorodin, Lorodin, Lorelaine R, Elisey, Erius.
Terms and conditions of storage
Diazolin belongs to the group of drugs allowed to leave from pharmacies in non-prescription mode.
Store the drug, according to the instructions, should be in a dry place at temperatures up to 25 ºC. With proper storage, the shelf life of tablets is 36 months, dragee - 42 months.