Diacarb - diuretic, a drug that promotes urination. It is widely used as a diuretic when salt and water are retained in the body in order to treat edema of various etiologies.
Release form and composition
Diacarb is released in tablets, each containing 250 mg of acetazolamide. Microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, croscarmellose sodium act as auxiliary substances of the medicament.
In blister packs of 10 tablets.
Indications for use
According to the instructions, Diacarb is indicated for use in the following cases:
- Mild to moderate severity of edema in combination with alkalosis;
- Epilepsy (as an adjunct treatment in combination with antiepileptic drugs);
- Relief of an acute attack of glaucoma (as part of a combined treatment) and the period of preparation for surgery;
- Increased intracranial pressure (benign hypertension, increased intracranial pressure after ventricular bypass) - in combination with other drugs;
- Acute altitude sickness (the drug reduces the time of acclimatization).
According to the instructions, Diacarb should not be used for:
- Acute renal failure (there is a possibility of encephalopathy);
- Deficiency of potassium and sodium in the body;
- First trimester pregnancy;
- Hypersensitivity to the active or auxiliary components of the drug;
- Children under three years.
Diacarb is prescribed with caution in the following cases:
- Combination with acetylsalicylic acid (at a dose of more than 300 mg per day);
- Edema renal and hepatic genesis;
- Pregnancy second and third trimester;
- Emphysema and pulmonary embolism (there is a likelihood of acidosis).
Dosing and Administration
Diakarb take inside. When edematous syndrome medication prescribed in a dose of 250 mg (1 tablet) in the morning. In order to ensure optimal therapeutic action, one should take the medicine once a day every other day or two days in a row with an interval of 1 day.
In case of glaucoma, Diacarb is indicated in combination with other medications. Adults with open-angle glaucoma are prescribed 250 mg (1 tablet) up to 4 times a day. The drug in high doses (more than 1000 mg per day) does not enhance the diuretic effect. In secondary glaucoma, 250 mg (1 tablet) is prescribed every 4 hours during the day. For the relief of an acute attack of glaucoma, it is recommended to use Diacarb every 4 hours, 1 tablet.
Children older than three years with attacks of glaucoma is prescribed for 10-15 mg of the drug per kg of body weight per day, divided into 3-4 doses. After 5 days of therapy, a two-day break should be taken.
In preparation for surgery, 250-500 mg (1-2 tablets) are prescribed the day before and in the morning before the operation.
In epilepsy, adult patients take 1-2 tablets of Diacarb in 1 dose for 3 days, then a one-day break is taken. The dose for children from three years is 8-30 mg per day per kg of weight, divided into 2-4 doses. The maximum daily dose is 750 mg (3 tablets).
In acute altitude sickness, it is recommended to take 500-100 mg (2-4 tablets) per day. The drug is recommended to take 1-2 days before climbing.
With increased intracranial pressure, diacarb is prescribed 250 mg (1 tablet) per day or 125-250 mg (0.5-1 tablet) every 8-12 hours.
The use of Diacarba can cause the following side effects:
- Central nervous system: tinnitus, hearing loss, paresthesia, disorientation, drowsiness, ataxia, dizziness, convulsions, hepatic encephalopathy, photophobia, flaccid paralysis, impaired touch;
- Hematopoietic system: thrombocytopenia, agranulocytosis, pancytopenia, bone marrow hematopoietic insufficiency, aplastic anemia, leukopenia, hemorrhagic diathesis;
- Urinary system: nephrolithiasis, frequent urination;
- Digestive system: nausea, vomiting, loss of appetite, fulminant liver necrosis, taste disturbance, diarrhea;
- Allergies: skin rash in the form of erythema multiforme, Stevens-Johnson syndrome, anaphylaxis, urticaria, Lyell's syndrome;
- From the laboratory parameters: hyperglycemia, impaired water and electrolyte balance, hyponatremia, hypokalemia, glucosuria, hematuria;
- Other side effects of Diakarba: muscle weakness, transient myopia.
In the presence of hypersensitivity to acetazolamide, life-threatening conditions can occur, such as fulminant liver necrosis, aplastic anemia, agranulocytosis, Lyell and Stevens-Johnson syndromes, hemorrhagic diathesis. In this case, the use of Diacarba should be discontinued.
It is not recommended to use the drug for more than 5 days in a row, since the risk of developing metabolic acidosis increases.
In case of an overdose of the drug, the following symptoms may develop:
- Metabolic acidosis;
- Violation of water and electrolyte balance;
- Violations of the central nervous system.
In this case, it is necessary to conduct symptomatic and supportive therapy. The level of electrolytes in the blood, in particular sodium and potassium, should be monitored, and the blood acidity should be monitored. With the development of metabolic acidosis, sodium bicarbonate should be used. Hemodialysis helps to remove acetazolamide.
Since Diacarb can cause drowsiness, dizziness and disorientation, it is recommended to refrain from controlling potentially dangerous mechanisms that require high concentration of attention during therapy.
Acetazolamide is a structural analogue of Diacarb.
Terms and conditions of storage
According to the instructions, diacarb stored at a temperature not exceeding 25 degrees Celsius, in a place protected from moisture and direct sunlight. It should take care of the drug from children. The shelf life of the drug is 5 years.