Danazol - a drug used in the treatment of diseases of the urogenital organs.
Release form and composition
Let out Danazol in the form of capsules, on 30 pieces. in polymer banks. The composition of one capsule includes 100 or 200 mg of danazol.
Indications for use
The drug is used in endometriosis with concomitant infertility, primary menorrhagia, as well as in the following cases:
- Hereditary angioedema;
- Benign neoplasms of the breast;
- Premature puberty in children;
- Premenstrual syndrome.
The use of Danazol is contraindicated in case of hypersensitivity to the components included in its composition, as well as in the following cases:
- Pregnancy and during the breastfeeding period;
- Concurrent use with anticoagulants and anticonvulsants;
With caution, the drug is prescribed to patients with diabetes, renal or heart failure.
Dosing and Administration
Capsules are ingested after meals. Reception of Danazol begins on the first day of the menstrual cycle.
The initial dose of the drug in cases of endometriosis is 4 capsules (100 mg each), further it is increased to 8 pcs. per day. The duration of therapy is on average six months.
In menorrhagia and premenstrual syndrome, patients take 1-4 capsules per day for 3 months. In cases of mastopathy prescribed for 3 pcs. per day for 3-6 months.
In case of premature puberty, children take 100-400 mg per day. The duration of therapy is determined by the doctor individually.
To prevent angioedema, the initial dose is 2 capsules. Further, in the absence of exacerbations, the dose of the agent is reduced. The duration of treatment varies within 1-3 months.
When using Danazol as a preoperative preparation for 1-2 months before surgery, patients take 3-4 capsules per day.
The instructions for Danazol indicate that the drug may cause side effects from some body systems, namely:
- Hypersecretion of sebaceous glands, edema, decrease in the size of the mammary glands, acne, hirsutism, weight gain, profuse sweat, coarsening of the voice, menstrual disorders, viril syndrome, changes in libido and vaginitis (endocrine system);
- Increased platelet or red blood cell count, leukocytosis, thrombocytopenia, or leukopenia (hematopoietic system);
- Bleeding in patients with hemophilia (blood coagulation system);
- Tachycardia and worsening of the course of arterial hypertension (cardiovascular system);
- Increased intracranial pressure (central nervous system);
- Hepatitis, increased activity of creatine kinase or liver enzymes, cholestatic jaundice, hypoglycemia, dyslipidemia and nausea (digestive system).
In rare cases, Danazol causes an increase in appetite, impaired vision, increased fatigue, lumbodynia, depressions, photosensitivity, skin rashes and skeletal muscle spasm.
Symptoms of a drug overdose are seizures, headache, nausea, tremor, dizziness and vomiting. In such cases, gastric lavage and the appointment of symptomatic treatment is required.
During the period of Danazol use, it is necessary to regularly conduct a survey of liver function, including the determination of the number of peripheral blood cells and liver enzymes.
It is important to know that the drug has an impact on laboratory indicators of sex hormones (increases testosterone levels, etc.).
Drug therapy in patients with thrombosis, kidney or liver disease, migraine, cardiovascular diseases and conditions accompanied by epilepsy, impaired lipoprotein metabolism and fluid retention should be carried out under close medical supervision.
In the appointment of Danazol patients with diabetes mellitus, dose adjustment of insulin is necessary.
It should be borne in mind that the drug increases the concentration of glucagon in the blood plasma, enhances the effect of derivatives of indanedione and coumarin anticoagulants, as well as:
- Increases blood concentration of antiepileptic drugs and inhibits their metabolism;
- Weakens the effects of oral hypoglycemic drugs and insulin;
- Reduces the effectiveness of antihypertensive drugs;
- Increases the concentration of tacrolimus and cyclosporine in the blood plasma.
The drug is synonymous with Danogar, Bonzol, Ladogar, Cyclomen and Dodogal. The counterparts of Danazol include Danoval, Danol, Nemestran and Danodiol.
Terms and conditions of storage
In accordance with the instructions, Danazol should be stored in a dark, dry and out of reach of children, at room temperature.
From pharmacies, the drug is released on prescription. The shelf life of Danazol is three years.