Butadion is a nonsteroidal anti-inflammatory drug.
Release form and composition
Butadion is issued in the form:
- Ointment for external use, in 1 gram of which contains 50 mg of phenylbutazone;
- Coated tablets with an active ingredient content of 30 or 50 mg;
- Tablets containing 150 mg of the active ingredient.
Indications for use
According to the instructions to Butadion, in the form of tablets, the drug is intended for use:
- As an anti-inflammatory and analgesic drug for diseases of the musculoskeletal system: rheumatic lesions of soft tissues, ankylosing spondyloarthritis, osteoarthritis of the peripheral joints and spine (including diseases with a radicular syndrome), bursitis, tendovaginitis, rheumatoid, psoriatic, psoriatic, psoriatic, psoriatic syndrome with sprains and bruises;
- As an anesthetic medicine for renal and biliary colic, post-traumatic pain syndrome, accompanied by inflammation, migraine, dental and headache, as well as pain syndrome of mild and moderate severity, caused by such diseases as gout, adnexitis, proctitis, arthralgia, myalgia, neuralgia, lumboischialgia and algomenorrhea;
- As a febrifuge in febrile syndrome caused by infectious and catarrhal diseases.
In the form of ointment, Butadion, according to the instructions, should be used with:
- Muscle strains and tendons;
- First and second degree burns of a small area;
- Dermatitis caused by mechanical stress;
- Inflammatory infiltrates;
- Insect bites;
- Diseases of the musculoskeletal system.
It is important to note that Butadion is intended for symptomatic therapy, reducing inflammation and the severity of pain at the time of its application and does not affect the progression of the disease.
According to the instructions to Butadion, the use of the drug in the form of tablets is contraindicated in:
- Complete or incomplete combination of intolerance to acetylsalicylic acid or any other NSAIDs, bronchial asthma and recurrent nasal polyposis and paranasal sinuses (including a history of);
- Exacerbations of erosive and ulcerative lesions of the gastrointestinal tract, including peptic ulcer, ulcerative colitis, duodenal ulcer and stomach ulcer;
- Bone marrow depression;
- Pulmonary heart disease;
- Decompensated chronic heart failure;
- Severe hepatic / renal failure;
- Progressive kidney disease;
- Active liver disease;
- Active gastrointestinal bleeding;
- The presence of inflammatory bowel disease.
In addition, Butadion is not prescribed in the first and third trimesters of pregnancy, children under 14 years of age, breastfeeding women, and patients in the period after coronary artery bypass surgery.
Assign pills, but with extreme caution:
- To old people;
- In the second trimester of pregnancy;
- Alcohol abusers;
- Smoking people;
- With prolonged use of NSAIDs;
- Simultaneously with oral corticosteroids (including prednisolone), anticoagulants, antiplatelet agents (including acetylsalicylic acid and clopidogrel), selective serotonin reuptake inhibitors.
During the period of use of Butadion, caution should also be observed in patients with:
- Chronic heart failure;
- Bronchial asthma;
- Chronic liver / kidney failure;
- Hearing loss;
- Pathology of the vestibular apparatus;
- Severe somatic diseases;
- Rheumatic polymyalgia;
- Systemic lupus erythematosus;
- Blood disorders;
- Ulcerogenic diseases of the gastrointestinal tract;
- Transient arteritis;
- Cerebrovascular diseases;
- Coronary heart disease;
- Ulcerative lesions of the gastrointestinal tract outside the acute stage;
- Dyslipidemia / hyperlipidemia;
- Peripheral arterial disease;
- The presence of Helicobacter pylori infection.
Dosing and Administration
Butadion tablets are taken orally after meals 3-4 times a day. The dosage is determined based on the type of disease and severity of pain. Adults are usually prescribed at 100-400 mg, children, depending on age - at 10-100 mg. The duration of treatment depends on the indication.
Butadion ointment with a thin layer (a strip of 2-3 cm in length) is applied over the focus of inflammation two or three times a day. Rub the tool is not necessary. The duration of use without consulting a doctor should not exceed 10 days.
The use of Butadion may be accompanied by the following side effects:
- Dyspeptic manifestations, with long-term use and / or in high doses - aphthous stomatitis, glossitis, abnormal liver function, ulceration of the gastrointestinal tract mucous membrane, bleeding, erosive esophagitis;
- Tinnitus, hearing loss;
- Increased blood pressure, tachycardia, heart failure;
- Headache, agitation, dizziness, drowsiness, depression;
- Agranulocytosis, anemia, leukopenia, thrombocytopenia;
- Skin rash, itching, urticaria, edematous syndrome, bronchospasm, angioedema;
- Increased sweating, uterine bleeding.
With external use are possible: photosensitivity, peeling, vesicles, papules, puffiness, eczema.
Structural analogue of Butadion tablets is Butadion-OBL.
In the form of ointment / gel / solution for external use of the mechanism of action analogues phenylbutazone can assume Artrozilen, Artrum, Bioran, Bystrumgel, Voltaren Emulgel, Diklak, Diklobene, Diklovit, Dikloran, Diclofenac, Dip Relief, Long, Ibalgin, Ibuprofen, Indobene, Ketonal , Nimulid, Ortofen, Sulaydin, Fastum gel, Finalgel, Fleksen, etc.
Terms and conditions of storage
The shelf life of Butadion ointment is 5 years if stored at a temperature of 8-15 ºС. Shelf life of tablets - 3 years at temperatures up to 25 ºС.