Bisoprolol is a beta1-blocker with hypotensive, antiarrhythmic and antianginal effects.
Release form and composition
The preparation is produced in the form of round coated tablets from beige yellow to beige color, containing:
- 5 mg or 10 mg of bisoprolol fumarate;
- Excipients: pregelatinized starch, colloidal silicon dioxide, croscarmellose sodium, microcrystalline cellulose, povidone, talc, magnesium stearate and lactose (milk sugar).
The composition of the film shell includes opadry II (macrogol, titanium dioxide, partially hydrolyzed polyvinyl alcohol, talc) and iron dye oxide (II).
Bisoprolol tablets are sold in 10 pcs. in blisters and 30 pcs. in banks of dark glass and polymer bottles.
Indications for use
According to the instructions for bisoprolol, this drug is prescribed:
- As an antihypertensive for the treatment of hypertension;
- As an antiarrhythmic and antianginal agent for the prevention of strokes in patients with coronary heart disease.
As indicated in the instructions for Bisoprolol, the following conditions and diseases are contraindications to the use of this medication:
- Hypersensitivity to bisoprolol fumarate, any auxiliary component of the drug or other beta-blockers;
- Children and adolescents (up to 18 years);
- Pulmonary edema;
- AV block II and III degree;
- Printsmetal angina;
- Severe bronchial asthma and other obstructive respiratory diseases;
- Severe bradycardia;
- Pheochromocytoma (in this case, the use of Bisoprolol is possible, but only simultaneously with alpha-blockers);
- Hypotension (at which the systolic pressure is less than 100 mm Hg. Art., Especially in myocardial infarction);
- Sick sinus syndrome (SSS);
- Chronic decompensated heart failure;
- Acute heart failure;
- Sinoatrial blockade;
- Cardiomegaly (if it is not accompanied by signs of heart failure);
- Late stages of impaired peripheral circulation;
- Raynaud's disease;
- Metabolic acidosis;
- Shock (including cardiogenic);
- The need for simultaneous use of MAO inhibitors (with the exception of MAO-B inhibitors).
Bisoprolol is prescribed, but with extreme caution, to elderly people, as well as to patients with:
- AV block I degree;
- Hepatic or chronic renal failure;
- Diabetes mellitus;
- Depression, including in the anamnesis.
Dosing and Administration
The drug bisoprolol should be taken in the morning on an empty stomach. Treatment begins with a dosage of 5 mg per day. With insufficient severity of the therapeutic effect, the dose is gradually increased to 10-20 mg.
Elderly dosage adjustment is not required, patients with severe impaired liver and kidney function is not recommended to exceed the dose of 10 mg.
Treatment with bisoprolol may be accompanied by the following side effects:
- On the part of the peripheral and central nervous system: headache, anxiety, increased fatigue, dizziness, weakness, asthenia, sleep disorders, short-term memory loss, myasthenia, tremor, confusion, hallucinations, convulsions;
- With the cardiovascular system: the development or aggravation of CHF, decrease in blood pressure, sinus bradycardia, weakening of myocardial contractility, orthostatic hypotension, angiospasm, palpitations, chest pain;
- On the part of the musculoskeletal system: back pain, cramps of the calf muscles, arthralgia;
- On the part of the senses: soreness and dryness of the eyes, conjunctivitis, impaired vision, a decrease in the secretion of tear fluid;
- On the part of the digestive system: abdominal pain, vomiting, constipation or diarrhea, dryness of the oral mucosa, changes in the level of bilirubin, impaired liver function, increased activity of liver enzymes;
- On the part of the respiratory system: nasal congestion, when used in high doses - difficulty breathing, bronchospasm;
- From the hemopoietic system: leukopenia, agranulocytosis, thrombocytopenia;
- On the part of the reproductive system: decreased potency or decreased libido.
In addition, when using Bisoprolol, dermatological and allergic reactions may occur due to hypersensitivity to the drug components, such as: pruritus, rash and urticaria, increased sweating, skin hyperemia, alopecia, psoriasis-like reactions and exacerbation of psoriasis.
Patients taking Bisoprolol require regular monitoring of heart rate and blood pressure: at the initial stage of treatment - daily, then - once every 3 months. Patients with diabetes, in addition, should once every 4-5 months to determine the level of glucose in the blood, and the elderly - to monitor renal function.
During the period of use of bisoprolol, care must be taken when driving and performing potentially hazardous work.
The following drugs are analogues of bisoprolol:
- According to the active substance: Aritel, Bidop, Biol, Biprol, Bisocard, Bisogamma, Bisomor, Konkor, Korbis, Kordinorm, Coronal, Niperten and Tirez;
- According to the mechanism of action: Atenolol, Betak, Betakkard, Betalok, Binelol, Breviblok, Vazokardin, Corvitol, Kordanum, Lidalok, Lokren, Metozok, Metokard, Metocor, Metoprolol, Nebivator, Nebivolol, Nebilet, neflong chitos, nebolong chytochne, nebolong Egilok, Estecor.
Terms and conditions of storage
Bisoprolol is a list B drug released from pharmacies by prescription. According to the recommendations of the manufacturer, it should be stored in a dry place protected from sunlight. The optimum temperature is 15-25 ºС. Shelf life of tablets is 3 years.