Bisogamma is a beta1-blocker that has a combined effect on the human body: hypotensive, antiarrhythmic and antianginal.
Release form and composition
Available in the form of film-coated tablets.
Light yellow Bisogamma tablets contain:
- 5 mg of bisoprolol hemifumarate;
- Excipients such as: pregelatinized starch, magnesium stearate, hypromellose (HPMC), macrogol 6000, crospovidone, microcrystalline cellulose, talc, titanium dioxide, colloidal silicon dioxide and iron dye yellow oxide.
Bisogamma tablets of yellow-orange color contain:
- 10 mg of bisoprolol hemifumarate;
- Excipients, such as: calcium carbonate, polysorbate 20, pregelatinized starch, magnesium stearate, hypromellose (HPMC5 and HPMC 50), macrogol 6000, crospovidone, microcrystalline cellulose, talc, titanium dioxide, colloidal silicon dioxide and dye, ferric oxide yellow.
Bisogamma tablets are sold in 10 pcs. in blisters, 3 or 5 pcs. packaged.
Indications for use
According to the instructions to Bisogamma, this drug is intended for:
- Arterial hypertension treatment;
- Prevention of angina attacks with coronary heart disease.
Contraindications to the use of Bisogamma, according to the instructions, are the following conditions and diseases:
- Sinoatrial blockade;
- Severe bradycardia;
- Acute heart failure;
- Chronic decompensated heart failure;
- Sick sinus syndrome;
- Hypotension (if the systolic pressure does not reach the level of at least 100 mm Hg., And especially with myocardial infarction);
- Metabolic acidosis;
- Fochromocytoma (without simultaneous use of alpha-blockers);
- Late stages of impaired peripheral circulation;
- Pulmonary edema;
- Raynaud's disease;
- Cardiomegaly (if it is not accompanied by signs of heart failure);
- Printsmetal angina;
- AV block II and III degree;
- Severe bronchial asthma and other obstructive respiratory diseases;
- Shock (including cardiogenic);
- Hypersensitivity to bisoprolol, any auxiliary component of the drug and other beta-blockers;
- Children's age (up to 18 years);
- The need for simultaneous use of MAO inhibitors (with the exception of MAO inhibitors of type B).
Assign Bisogamma, but with extreme caution, the elderly, as well as patients with:
- Chronic renal failure;
- Liver failure;
- AV block I degree;
- Diabetes mellitus;
- A history of indications of depression or allergic reactions.
Dosing and Administration
The recommended initial dosage is 5 mg. A pill is taken once a day, in the morning on an empty stomach. With insufficient therapeutic effect, the dose is increased to 10 mg. The maximum allowable dosage is 20 mg per day.
For patients with severe impaired renal function (with creatinine clearance up to 20 ml / minute) and liver function, the daily dose of Bisogamma should not exceed 10 mg.
Bisogamma administration may be accompanied by:
- Fatigue, headache, anxiety, dizziness, sleep disorders, weakness, asthenia, short-term memory loss or confusion, myasthenia, tremor, hallucinations, convulsions (from the peripheral and central nervous system);
- Decreased secretion of the tear fluid, conjunctivitis, visual impairment, soreness and dryness of the eyes (on the part of the senses);
- Sinus bradycardia, weakening of myocardial contractility, palpitations, development or worsening of CHF, decrease in blood pressure, angiospasm, orthostatic hypotension, chest pain (reaction of the cardiovascular system to taking Bisogamma);
- A change in taste, nausea, abdominal pain, vomiting, dryness of the oral mucosa, impaired liver function, constipation or diarrhea, changes in the level of bilirubin, increased activity of liver enzymes (on the part of the digestive system);
- Nasal congestion, when used in high doses - difficulty in breathing, bronchospasm (on the part of the respiratory system);
- Leukopenia, agranulocytosis, thrombocytopenia (from the hematopoietic system);
- Decreased potency, weakening of libido (from the reproductive system);
- Cramps calf muscles, arthralgia, back pain (from the musculoskeletal system);
- Pruritus, urticaria, skin hyperemia, increased sweating, psoriasis-like skin reactions, alopecia, exacerbation of psoriasis (allergic and dermatological reactions).
With the use of Bisogamma during pregnancy, bradycardia, hypoglycemia, as well as intrauterine growth retardation are possible.
During the period of treatment with this drug, regular monitoring of heart rate and blood pressure is necessary, in elderly patients - also renal function, in patients with diabetes mellitus - blood glucose level.
Structural analogues of Bisogamma are the following drugs: Aritel, Bidop, Biol, Biprol, Bisocard, Bisomor, Bisoprolol, Concor, Corbis, Kordinorm, Coronal, Niperten, Tirez.
Mechanism of action counterparts Bisogamma can be considered such medications: atenolol, Betacam, Betakard, Betalok, Binelol, Breviblok, Vazokardin, Korvitol, Kordanum, Lidalok, Lokren, Metozok, Metokard, Metokor, metoprolol, Nebivator, Nebilet, Nebilong, Nevotenz, Serdol, Egilok, Estecor.
Terms and conditions of storage
Bisogamma is a prescription drug. According to the manufacturer’s recommendations, it should be stored in a dry place protected from sunlight. The optimum temperature is 15-25 ºС. Shelf life of tablets is 3 years.