Biol

Biol - a drug used in the treatment of diseases of the cardiovascular system.

Release form and composition

The drug is produced in the form of light yellow biconvex round, film-coated tablets, on one side of which there is a cross-shaped risk, and on the other side engraving "BIS 5", 10 pieces each. in blisters.

One Biola tablet contains 5 mg of bisoprolol hemifumarate and such excipients as:

• Magnesium stearate;
• Corn starch;
• Microcrystalline cellulose;
• Croscarmellose sodium;
• Calcium hydrogen phosphate;
• Silicon dioxide anhydrous colloid.

They also produce biconvex yellow round tablets Biol, film-coated, with a cross-shaped risk on one and an engraving “BIS 10” on the other side, in cell contour packages of 10 pcs.

Each of them contains 10 mg of bisoprolol hemifumarate and the same excipients as 5 mg tablets.

The composition of the film shell, covering 5 and 10 mg tablets, includes lactose monohydrate, macrogol-4000, hypromellose, titanium dioxide and iron dye yellow oxide.

Indications for use

In accordance with the instructions, Biol is prescribed in cases of treatment of chronic heart failure, coronary heart disease and arterial hypertension.

Contraindications

The use of Biola is contraindicated in combination with sultoprid and floctafenin, children under 18 years old, with metabolic acidosis, cardiogenic shock, bradycardia, sinoatrial blockade and weakness of the sinus node, as well as in cases of patient hypersensitivity to any component of the component, collapse and chronic obstructive lung disease.

The drug is not prescribed in cases of chronic and acute heart failure, cardiomegaly, marked impairment of the peripheral circulation, AV blockade of the second and third degree, arterial hypotension and Raynaud's syndrome.

With caution, Biol is prescribed for psoriasis, first-degree AV blockade, hyperthyroidism, pheochromocytoma, Prinzmetal angina pectoris, type 1 diabetes mellitus, restrictive cardiomyopathy, depression, desensitization therapy, strict diet, abnormal liver function and severe renal failure, as well as insensitivity of liver function and respiratory failure, as well as insensitive liver function chronic heart failure with myocardial infarction and congenital valvular and cardiac defects.

Dosing and Administration

The drug is taken on an empty stomach in the morning inside, with 250 ml of clean drinking water or juice. The dosage of the agent and the duration of treatment with Biol is determined by the doctor individually, depending on the disease and the patient's response to treatment.

The average daily dose for arterial hypertension and coronary heart disease is 5 mg. In chronic heart failure, the initial dose of Biola is 1.25 mg once a day, followed by a gradual increase to 7.5 mg of the drug per day.

Side effects

The instructions to Biol indicated that the drug may cause side effects from some body systems, namely:

• Headache, dizziness and fatigue, asthenia, sleep disturbances and depression, confusion, myasthenia and anxiety, tremor, muscle cramps and hallucinations (nervous system);
• Nasal congestion, bronchospasm and allergic rhinitis (respiratory system);
• A marked decrease in blood pressure, impaired AV conduction, chest pain, aggravation of chronic heart failure, palpitations, arrhythmias and orthostatic hypotension (cardiovascular system)
• Constipation, nausea, diarrhea, hepatitis, abdominal pain, vomiting and dryness of the oral mucosa (digestive system);
• Decreased hearing, impaired vision and taste, decreased tearing, conjunctivitis, and dry eyes (sensory organs).

Also Biol, according to the instructions, in some cases causes such side effects and reactions as:

• Urticaria, pruritus and rash (allergic reactions);
• Back pain and arthralgia (musculoskeletal system);
• Leukopenia, an increase in the concentration of triglycerides in the blood, agranulocytosis and thrombocytopenia (laboratory values);
• Exanthema, increased sweating, alopecia and hyperemia of the skin (skin);
• Impairment of potency and weakening of libido (urinary system).

special instructions

In cases of abrupt drug withdrawal, the risk of severe arrhythmia and myocardial infarction increases significantly. The termination of the use of Biola should occur gradually, it is recommended every three or four days to reduce the dose by a quarter.

With long-term use of the drug, it is important every five months to determine the concentration of sugar in the blood of patients with diabetes mellitus, in other groups of patients it is recommended to regularly conduct an ECG, measure heart rate and blood pressure.

To reduce the dose of the drug or completely cancel Biol therapy is necessary in the following cases:

• When a patient becomes depressed;
• Two days before the planned surgery.
• With a decrease in blood pressure, the emergence of increasing bradycardia or AV blockade.

Before starting treatment with a remedy, it is important to warn patients that long-term use of Biola affects the ability to drive complex mechanisms and vehicles.

Analogs

The drug is synonymous with Bidop and Aritel. Analogs of Biola are such medicines as:

• Tirez;
• Niperten;
• Concor;
• Bisoprolol.

Terms and conditions of storage

Biol, according to the instructions, should be stored in a dry place inaccessible to children and light, at a temperature not exceeding 25 ° C.

Release the drug from pharmacies by prescription. The shelf life of the drug is four years. After the expiration date of Biol must be disposed of.